Your Input: | |
| | Sh | Potassium voltage-gated channel protein Shaker; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Forms rapidly inactivating tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient and may contribute to A- type currents. Plays a role in the regulation of sleep need or efficiency ; Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) s [...] (655 aa) |
| | CG16952 | Uncharacterized protein, isoform H. (1043 aa) |
| | CG11714 | GH09976p. (383 aa) |
| | mamo | Maternal gene required for meiosis (mamo) encodes a zinc finger C2H2 transcription factor enriched in embryonic primordial germ cells. It is required for functional gamete production. (1553 aa) |
| | CG7102 | LD40565p; It is involved in the biological process described with: spliceosomal snRNP assembly. (515 aa) |
| | lola | Longitudinals lacking protein, isoforms F/I/K/T; Longitudinals lacking (lola) encodes a protein involved in Notch signaling, cell death, regulation of retrotransposons and expression of axon and dendrite patterning genes. It contributes to oogenesis, spermatogenesis, neural wiring, eye development and a variety of behaviors. (970 aa) |
| | CG3726 | Uncharacterized protein, isoform B; DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II. (682 aa) |
| | rad | Radish, isoform I; Radish (rad) encodes a protein involved in anesthesia-resistant memory and heart contraction regulation. (1799 aa) |
| | inc | Insomniac, isoform B; Insomniac (inc) encodes a BTB domain-containing protein that is essential in neurons for normal sleep-wake cycles. (211 aa) |
| | KLHL18 | Kelch like family member 18, isoform A; Protein homodimerization activity. It is involved in the biological process described with: protein autoubiquitination; imaginal disc fusion, thorax closure. (575 aa) |
| | CG43980 | Uncharacterized protein, isoform C; Protein heterodimerization activity. (1549 aa) |
| | Shab | Potassium voltage-gated channel protein Shab; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. (1607 aa) |
| | CG13917 | GH15728p. (2019 aa) |
| | CG6765 | Uncharacterized protein, isoform A; Nucleic acid binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II. (681 aa) |
| | Trl | Transcription factor GAGA; Transcriptional activator that functions by regulating chromatin structure. Overcomes the repressive effects of chromatin by promoting the open chromatin conformation in promoter gene regions, thereby allowing access to other transcription factors. Binds to DNA Polycomb response elements (PREs) at the bithorax complex and to the proximal region of the engrailed promoter, and positively regulates transcription of many genes including homeotic ones. Binds to the DNA sequence (GA)n, with optimal binding to the pentamer 5'-GAGAG-3'. Binds DNA as an oligomer. May [...] (623 aa) |
| | ab | Protein abrupt; Expression is vital for development; may be involved in transcriptional regulation. In embryos, muscle specific expression is required for segmental nerve b (SNb) motoneuron target recognition within ventral longitudinal muscles. Has a role in establishing and maintaining embryonic muscle attachments, adult sensory cell formation (macrochaetae) and morphogenesis of adult appendages (legs, antenna aristae and male external genitalia). Has a role in the morphogenesis of the class I dendritic neurons: selective expression of ab in class I da neurons plays a pivotal role in [...] (904 aa) |
| | Lztr1 | Leucine-zipper-like transcriptional regulator 1 homolog; Inhibitor of Ras signaling. Acts as a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin- protein ligase complex that mediates ubiquitination of Ras (By similarity); Belongs to the LZTR1 family. (998 aa) |
| | psq | Pipsqueak, isoform M; Pipsqueak (psq) encodes a transcription factor that regulates chromatin silencing. It mediates the interaction of Polycomb group (Pc-G) members with Pc-G response elements. (1123 aa) |
| | CG15097 | Uncharacterized protein, isoform E. (743 aa) |
| | br | Broad-complex core protein isoform 6; Broad-complex proteins are required for puffing and transcription of salivary gland late genes during metamorphosis. (1011 aa) |
| | lov | Protein jim lovell; Has a regulatory role during midline cell development. (1143 aa) |
| | RhoBTB | Rho-related BTB domain containing (RhoBTB) encodes a protein involved in anti-parasitoid immune response. (783 aa) |
| | rib | Ribbon, isoform C; Ribbon (rib) encodes a nuclear BTB-domain protein, expressed in most embryonic cells. It is required for development of the salivary gland and trachea, as well as for dorsal closure. It regulates both growth and differentiation of salivary gland cells. (680 aa) |
| | lute | Lute, isoform D; Lute (lute) encodes a protein involved in neurogenesis. (735 aa) |
| | twz | Tiwaz, isoform B; It is involved in the biological process described with: adult feeding behavior; adult locomotory behavior; protein homooligomerization; inter-male aggressive behavior; male courtship behavior. (367 aa) |
| | Shawl | Shaw-like, isoform C; Delayed rectifier potassium channel activity; voltage-gated potassium channel activity; voltage-gated cation channel activity. It is involved in the biological process described with: potassium ion transmembrane transport; potassium ion transport; protein homooligomerization. (937 aa) |
| | BtbVII | BTB-protein-VII, isoform F; DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II. (907 aa) |
| | CG43120 | BTB domain-containing protein. (286 aa) |
| | chinmo | Zinc finger protein chinmo; Required for morphological differentiation of postmitotic neurons during postembryonic brain development. Ensures production of appropriate neuron subtypes within a lineage by preventing precocious generation of late neuronal types of that lineage. Acts as a downstream mediator of the transcriptional activator Stat92e and is required for the development of the eye- antennal disk which gives rise to the adult eye, antenna and head capsule, for transcriptional repression of the Notch receptor ligand Ser and for the self-renewal of cyst stem cells in the testis [...] (840 aa) |
| | fru | Sex determination protein fruitless; Probably acts as a transcriptional regulator. Part of the somatic sex determination hierarchy; sex determination genes transformer (tra) and transformer-2 (tra-2) switch fru splicing from the male-specific pattern to the female-specific pattern through activation of the female-specific fru 5'-splice site. Vital for the development of males and females. Controls the development of the male specific abdominal muscle of Lawrence. Plays a role in male courtship behavior and sexual orientation. Enhances male-specific expression of takeout in brain-associ [...] (960 aa) |
| | CG7058 | GH01369p; Ubiquitin protein ligase binding. It is involved in the biological process described with: regulation of proteolysis; ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process. (1062 aa) |
| | CG14647 | BTB domain-containing protein; It is involved in the biological process described with: protein homooligomerization. (335 aa) |
| | Shaw | Shaker cognate w (Shaw) encodes a voltage-gated potassium channel (Kv3.1) that mediates a non-inactivating potassium current open at resting membrane potential. It is important for controlling excitability of motor neurons and clock neurons. It regulates circadian rhythms and is in a pathway with the product of qsm and Na[+] K[+] Ca[2+] Co-transporter. (619 aa) |
| | CG41099 | Uncharacterized protein, isoform C; Metal ion binding. It is involved in the biological process described with: epithelial cell morphogenesis; embryonic morphogenesis; endocytosis. (1124 aa) |
| | klhl10 | Kelch like family member 10 (klhl10) encodes a protein that functions in spermatogenesis. It recruits substrates for a testis specific Cullin-3-based E3 ubiquitin ligase complex, which is required for caspase activation during the non-apoptotic process of spermatid terminal differentiation. (767 aa) |
| | CG32121 | Uncharacterized protein; Sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II. (648 aa) |
| | CG6118 | Uncharacterized protein, isoform C; It is involved in the biological process described with: regulation of transcription by RNA polymerase II. (967 aa) |
| | Shal | Potassium voltage-gated channel protein Shal; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. May play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. (571 aa) |
| | CG34376 | RT01151p; RNA polymerase II cis-regulatory region sequence-specific DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II. (681 aa) |
| | rdx | Protein roadkill; Involved in segment polarity. In complex with gft/CUL3, promotes ubiquitination of ci and its subsequent degradation by the proteasome, which results in hh signaling attenuation. This regulation may be important during eye formation for proper packing of ommatidia into a hexagonal array. (829 aa) |
| | CG30357 | FI08262p. (451 aa) |
| | gcl | Germ cell-less (gcl) encodes a conserved BTB (broad-complex, tramtrack, and bric-a-brac) protein that mediates transcriptional repression in the germline and the degradation of the receptor tyrosine kinase encoded by tor, which in turn allows germ cell formation. (569 aa) |
| | CG8060 | Protein tyrosine kinase inhibitor activity. It is involved in the biological process described with: negative regulation of protein tyrosine kinase activity. (1189 aa) |
| | gprs | Serine-enriched protein. (1302 aa) |
| | lolal | Longitudinals lacking protein-like; Required, together with Trl, for maintaining the repressed state of target genes including homeotic genes Scr and Ubx. May also be involved in the activation of homeotic genes. Binds to a DNA Polycomb response element (PRE) at the bithorax complex. Also binds to polytene chromosomes at several hundred sites, many of which are shared with Trl and ph-p. Required during embryonic development. (127 aa) |
| | CG10465 | RE57120p; It is involved in the biological process described with: protein homooligomerization. (301 aa) |
| | ttk | Protein tramtrack, alpha isoform; Binds to a number of sites in the transcriptional regulatory region of ftz. Isoform alpha is required to repress genes that promote the R7 cell fate. Probable repressor of the transcription of the segmentation genes ftz, eve, h, odd, run, and en. May bind to the region 5'-AGGG[CT]GG-3'. Degradation of ttk is directed by binding of sinah or sina, via the adapter molecule phyl which binds to the BTB domain of ttk. (813 aa) |
| | Rnb | LD33331p; It is involved in the biological process described with: regulation of circadian rhythm. (975 aa) |
| | CG14262 | AT19988p. (312 aa) |
| | CG14260 | Uncharacterized protein, isoform A; It is involved in the biological process described with: adult somatic muscle development. (249 aa) |
| | mod(mdg4) | Modifier of mdg4; Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independe [...] (610 aa) |
| | Ktl | Kctd12-like, isoform A; Kctd12-like (Ktl) encodes a protein involved in male aggression and mating behavior. (228 aa) |
| | Keap1 | Keap1, isoform B; Keap1 (Keap1) encodes a protein that interacts with the product of cnc to regulate the activation of genes by oxidative stress. (776 aa) |
| | Cp190 | Centrosome-associated zinc finger protein CP190; Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the [...] (1096 aa) |
| | CG9467 | LD44003p; Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. It is involved in the biological process described with: protein homooligomerization; oxidation-reduction process. (730 aa) |
| | kel | Ring canal kelch protein; Kelch (kel) encodes a substrate targeting component of a Cullin3-RING ubiquitin E3 ligase. It binds F-actin in vitro, while its predominant in vivo function is in the ubiquitin-proteasome pathway. It has an essential role in oogenesis, where it is required for cytoskeletal organization in ovarian ring canals. (1477 aa) |
| | CG9426 | GH03286p; Actin binding. (627 aa) |
| | CG17068 | LP10161p; It is involved in the biological process described with: neurogenesis. (694 aa) |
| | CG1812 | LD33804p. (616 aa) |
| | dbo | Kelch-like protein diablo; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May have a role in synapse differentiation and growth. (623 aa) |
| | CG8924 | LD19131p; DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II. (514 aa) |
| | CG8260 | Uncharacterized protein, isoform A. (415 aa) |
| | CG15725 | Uncharacterized protein; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity. It is involved in the biological process described with: regulation of transcription by RNA polymerase II. (745 aa) |
| | Tango10 | Transport and golgi organization 10, isoform A; It is involved in the biological process described with: protein secretion. (587 aa) |
| | CG15812 | FI07618p; DNA binding. It is involved in the biological process described with: regulation of transcription by RNA polymerase II. (518 aa) |
| | bab1 | Protein bric-a-brac 1; Bric a brac 1 (bab1) encodes a transcriptional regulator that functions partially redundantly with the product of bab2. It is part of the conserved proximal-distal gene regulatory network module. It contributes to pattern formation, ovary morphogenesis, abdominal pigmentation and olfactory receptor neuron fate diversity. (977 aa) |
| | bab2 | Protein bric-a-brac 2; Bric a brac 2 (bab2) encodes a transcriptional regulator that functions partially redundantly with the product of bab1. It is part of the conserved proximal-distal gene regulatory network module. It contributes to pattern formation, ovary morphogenesis, abdominal pigmentation and olfactory receptor neuron fate diversity. (1067 aa) |
| | mri | Mrityu, isoform A; Mrityu (mri) encodes a BTB/POZ domain containing protein. Its expression is regulated by the product of klu during retinal apoptosis. mri protein is phosphorylated upon egg activation, and is required for early embryo development and for the normal sensory perception of touch. (439 aa) |
| | ken | Transcription factor Ken; Transcription factor required for terminalia development. Negative regulator of the JAK/STAT pathway: represses JAK/STAT- dependent expression of ventral veins lacking (vvl) in the posterior spiracles. (601 aa) |
| | CG11275 | FI01029p; Ubiquitin protein ligase binding. It is involved in the biological process described with: ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of proteolysis. (417 aa) |
| | CG17754 | LP02641p. (654 aa) |
| | CG12236 | FI01104p; Nucleic acid binding; DNA-binding transcription repressor activity, RNA polymerase II-specific. It is involved in the biological process described with: negative regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II. (553 aa) |
