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| | CG6724 | Ribosome biogenesis protein WDR12 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat WDR12/YTM1 family. (420 aa) |
| | CG14805 | FI20216p1; It is involved in the biological process described with: regulation of DNA-dependent DNA replication initiation; rRNA processing. (506 aa) |
| | CG3071 | LD43561p; snoRNA binding. It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); rRNA processing; positive regulation of transcription by RNA polymerase I. (535 aa) |
| | fzr | Fizzy-related, isoform A; Fizzy-related (fzr) encodes a protein that binds to the Anaphase-Promoting Complex/Cyclosome (APC/C) ubiquitin ligase to stimulate its activity during G1 phase. (478 aa) |
| | wuho | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wuho; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required during gametogenesis. (424 aa) |
| | CG3184 | GH14157p; Demethylase activity. It is involved in the biological process described with: peptidyl-diphthamide biosynthetic process from peptidyl-histidine. (356 aa) |
| | Hira | Protein HIRA homolog; Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Required for replication-independent chromatin assembly. Promotes remodeling of sperm chromatin following fertilization via the incorporation of histone H3.3 and histone H4. Belongs to the WD repeat HIR1 family. (1047 aa) |
| | CG1571 | FI19907p1; Dynein heavy chain binding; dynein light chain binding. It is involved in the biological process described with: microtubule-based movement; outer dynein arm assembly; cilium movement. (651 aa) |
| | Gbeta5 | RH17413p; GTPase activator activity; G-protein gamma-subunit binding. It is involved in the biological process described with: G protein-coupled receptor signaling pathway; dopamine receptor signaling pathway; positive regulation of GTPase activity. (358 aa) |
| | CG2260 | LD41718p; It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (609 aa) |
| | APC4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (775 aa) |
| | Lst8 | Protein LST8 homolog; Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. Essential for TORC2-mediated regulation of cell growth and phosphorylation of Akt1. However it is not required for TORC1-mediated functions such as TORC1- dependent regulation of cell growth, autophagy and phosphorylation of S6K ; Belongs to the WD repeat LST8 family. (313 aa) |
| | Rae1 | Rae1 (Rae1) encodes a nucleoporin member of the WD40-repeat beta propeller protein super family. Biological roles of the pleiotropic Rae1 gene product include poly(A)+ mRNA export, cell cycle regulation, male meiosis control and male germ cell post-meiotic differentiation. (346 aa) |
| | CG4329 | FI01301p; It is involved in the biological process described with: sensory perception of sound. (1171 aa) |
| | CG12782 | WD_REPEATS_REGION domain-containing protein; Ubiquitin binding; RNA binding. It is involved in the biological process described with: RNA export from nucleus; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; mRNA export from nucleus. (336 aa) |
| | l(2)dtl | Protein lethal(2)denticleless; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of E2f during S phase. E2f degradation is necessary to ensure proper development. Substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, leading to recruit the DCX(DTL) complex; Belongs to the WD repeat cdt2 family. (769 aa) |
| | CG5543 | Gastrulation defective protein 1 homolog; It is involved in the biological process described with: regulation of histone H2B conserved C-terminal lysine ubiquitination; regulation of DNA double-strand break processing; Belongs to the WD repeat GAD-1 family. (655 aa) |
| | CG2812 | WD_REPEATS_REGION domain-containing protein. (348 aa) |
| | fzr2 | Fizzy-related 2 (fzr2) is exclusively expressed in testis and encodes a protein that binds to the anaphase-promoting complex/cyclosome (APC/C). As for the related proteins encoded by fzr, fzy and cort, it activates the ubiquitin ligase activity of the APC/C and allows the recruitment of target proteins such as those encoded by CycA, CycB, CycB3 and pim. (451 aa) |
| | CG3511 | LD39850p; Peptidyl-prolyl cis-trans isomerase activity. It is involved in the biological process described with: protein peptidyl-prolyl isomerization. (637 aa) |
| | CG16896 | LD44910p; GTPase activator activity. It is involved in the biological process described with: regulation of GTPase activity. (988 aa) |
| | Dic61B | Dynein intermediate chain at 61B (Dic61B) encodes an axonemal dynein intermediate chain protein expressed specifically in male germ cells. It is required for the development and precise assembly of sperm axonemes, thus it is essential for male fertility. (764 aa) |
| | CG8001 | Uncharacterized protein, isoform A. (748 aa) |
| | Oseg4 | Outer segment 4, isoform A; It is involved in the biological process described with: intraciliary retrograde transport; cilium assembly; positive regulation of canonical Wnt signaling pathway; non-motile cilium assembly. (1205 aa) |
| | CG13930 | WD_REPEATS_REGION domain-containing protein; Dynein heavy chain binding; dynein light chain binding. It is involved in the biological process described with: microtubule-based movement; cilium movement. (685 aa) |
| | alphaCOP | Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. (1234 aa) |
| | ago | F-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Probably recognizes and binds to phosphorylated target proteins (By similarity). In the wing and eye, negatively regulates cell growth and proliferation by mediating the degradation of Myc and cyclin E, respectively. Required for endocycles, but not mitosis in follicle cell epithelium. (1326 aa) |
| | Tango4 | Transport and golgi organization 4; It is involved in the biological process described with: mRNA splicing, via spliceosome; protein secretion; Golgi organization. (482 aa) |
| | Tomosyn | Tomosyn, isoform C; Tomosyn (Tomosyn) encodes a protein involved in long-term memory and neuromuscular synaptic transmission. (1470 aa) |
| | CG12608 | LD30439p; It is involved in the biological process described with: ribosomal large subunit biogenesis. (443 aa) |
| | CG9123 | FI12409p; It is involved in the biological process described with: ribosome biogenesis; cell population proliferation. (434 aa) |
| | kat80 | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (819 aa) |
| | Gbeta76C | Guanine nucleotide-binding protein subunit beta-2; G protein beta-subunit 76C (Gbeta76C) encodes a protein that forms a Gbeta-gamma complex that is anchored to the plasma membrane via lipid modification of the gamma-subunit. The Gbeta-gamma complex plays an essential role in phototransduction by presenting the Gqalpha-subunit to rhodopsin GPCRs for efficient activation, and preventing spontaneous GDP-GTP exchange on the Gqalpha-subunit. (346 aa) |
| | Wdr92 | WD repeat domain 92; Protein domain specific binding; ubiquitin binding. It is involved in the biological process described with: positive regulation of transcription by RNA polymerase II; calcineurin-NFAT signaling cascade. (375 aa) |
| | U4-U6-60K | U4-U6 small nuclear riboprotein factor 60K; U4 snRNA binding; U6 snRNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (553 aa) |
| | mus302 | RE72625p; Ubiquitin protein ligase activity; ubiquitin-protein transferase activity; zinc ion binding. It is involved in the biological process described with: protein ubiquitination; interstrand cross-link repair. (608 aa) |
| | CG13074 | Ig-like domain-containing protein; Dynein heavy chain binding; dynein light chain binding. It is involved in the biological process described with: intraciliary transport; microtubule-based movement. (451 aa) |
| | CG7275 | LD28275p; It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (446 aa) |
| | flr | Actin-interacting protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Essential for organismal and cell viability. Required for the development of normal wing cell planar polarity. (608 aa) |
| | CG10646 | RH33377p; It is involved in the biological process described with: protein ubiquitination. (383 aa) |
| | can | Cannonball (can) encodes a testis-specific TBP-associated factor essential for spermatogenesis. It is required for the normal level of expression of a large number of spermatogenesis genes and is strongly associated with the nucleolus in primary spermatocytes. (942 aa) |
| | Pex7 | Peroxin 7, isoform A; Peroxisome matrix targeting signal-2 binding. It is involved in the biological process described with: peroxisome organization; protein import into peroxisome matrix. (339 aa) |
| | CG14838 | Uncharacterized protein; Dynein heavy chain binding; dynein light chain binding. It is involved in the biological process described with: microtubule-based movement; outer dynein arm assembly; cilium movement. (1132 aa) |
| | CG10064 | WD_REPEATS_REGION domain-containing protein. (742 aa) |
| | CG3515 | FI19335p1; Chromatin binding; histone methyltransferase activity (H3-K4 specific). It is involved in the biological process described with: histone H3-K4 trimethylation. (395 aa) |
| | mio | GATOR complex protein MIOS; An essential component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. GATOR2 activates the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyte [...] (867 aa) |
| | frtz | Fritz (frtz) encodes a cytoplasmic protein that functions as a planar polarity effector as a downstream member of the fz-stan planar cell polarity pathway that controls hair and bristle polarity. frtz protein directly binds to the product of in and accumulates on the proximal side of wing cells. (951 aa) |
| | ebi | F-box-like/WD repeat-containing protein ebi; F-box-like component of E3 ubiquitin ligase complexes; involved in R7 photoreceptor cell differentiation, cone cell development and neuronal cell cycle control. E3 ubiquitin ligase complexes mediate ubiquitination and subsequent proteasomal degradation of target proteins. Required for specification of R7 photoreceptor cell fate in the eye by participating in the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), a general inhibitor of photoreceptor differentiation. Required to block the S phase entry in the peripheral [...] (700 aa) |
| | Nle | Protein Notchless; Plays a role in regulating Notch activity. Belongs to the NLE1/RSA4 family. (488 aa) |
| | rempA | Reduced mechanoreceptor potential A (rempA) encodes the IFT140 subunit of the IFT-A subcomplex. As such, it is a component of the conserved intraflagellar transport (IFT) mechanism and is needed to extend cilia above the cell surface. (1503 aa) |
| | Rbbp5 | Retinoblastoma-binding protein 5 homolog; Component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which also methylates histone H3 'Lys-4'. (489 aa) |
| | Rich | Guanine nucleotide exchange factor subunit Rich; Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi (By similarity). Plays a role in regulating Rab6-dependent CadN transport in photoreceptor cells which is required for the formation of normal synaptic connections between axons from the inner photoreceptor cells in the eye and postsynaptic cells in the brain medulla layer M6, and for the generation of normal postsynaptic responses. (1429 aa) |
| | Wdr33 | WD repeat domain 33, isoform A; It is involved in the biological process described with: mRNA polyadenylation. (807 aa) |
| | eIF3i | Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (326 aa) |
| | bchs | Blue cheese (bchs) is a neuronally expressed gene that encodes a member of the BEACH (Beige and Chediak-Higashi)-domain superfamily, whose members are involved in vesicle trafficking. It antagonizes the activity of the product of Rab11. It serves as a scaffold for autophagy proteins, and contributes to ref(2)P-mediated aggrephagy. It contributes to nervous system development, lysosome transport and sphingolipid metabolism. (3489 aa) |
| | CG9175 | FI09914p; GTPase activator activity; Sar guanyl-nucleotide exchange factor activity; GTPase binding. It is involved in the biological process described with: cell morphogenesis; regulation of COPII vesicle coating; protein secretion. (445 aa) |
| | Fbw5 | F-box and WD repeat domain containing 5 (Fbw5) encodes a protein that targets proteins for destruction via its role as a substrate receptor for the CRL4 E3 ubiquitin ligase. A key target of the product of Fbw5 is the subunit of the tuberous sclerosis complex encoded by gig, an important negative regulator of cellular growth via inhibition of the TOR kinase pathway. (656 aa) |
| | cort | Protein cortex; Female meiosis-specific activator of the anaphase promoting complex/cyclosome (APC/C). Required for the completion of meiosis in oocytes. Activates the ubiquitin ligase activity and substrate specificity of APC/C and triggers the sequential degradation of mitotic cyclins in meiosis. Promotes the ubiquitination and degradation of CycA early in meiosis I and the degradation of CycB and CycB3 after egg activation. Promotes degradation of mtrm at the oocyte-to-embryo transition. Belongs to the WD repeat CORT family. (483 aa) |
| | Wdr82 | WD repeat domain 82 (Wdr82) encodes a component of the Compass complex, which performs K4 methylation of the histone encoded by His3. (317 aa) |
| | Wdfy2 | WD repeat and FYVE domain containing 2, isoform A; Protein kinase binding; metal ion binding. (408 aa) |
| | Ge-1 | Enhancer of mRNA-decapping protein 4 homolog; In the process of mRNA degradation, seems to play a role in mRNA decapping. Required for silencing a subset of endogenous miRNA targets. (1354 aa) |
| | escl | Escl, isoform A; Escl (escl) encodes an essential component of the Polycomb Repressive Complex 2, whose function is to methylate histone H3K27. Although the product of escl is functionally equivalent to the product of esc, it is not maternally supplied in equally high levels and some homeotic phenotypes occur in the absence of the product of esc. (462 aa) |
| | Wdr81 | WD repeat domain 81. (1953 aa) |
| | esc | Polycomb protein esc; Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitme [...] (425 aa) |
| | beta'COP | Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (914 aa) |
| | CG10859 | GH14707p; Dynein light chain binding; dynein heavy chain binding. It is involved in the biological process described with: microtubule-based movement; cilium movement; outer dynein arm assembly. (627 aa) |
| | Arpc1 | Actin-related protein 2/3 complex, subunit 1 (Arpc1) encodes one of seven components of the highly conserved Arp2/3 complex. The Arp2/3 complex is required for many cellular and developmental processes requiring F-actin polymerization, including germline ring canal growth, embryonic cellularization, myoblast fusion, and endocytosis. (377 aa) |
| | l(2)34Fd | Lethal (2) 34Fd; It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (721 aa) |
| | CG4935 | AT12460p; Molecular adaptor activity. It is involved in the biological process described with: mRNA splicing, via spliceosome. (308 aa) |
| | fzy | FI02843p; Fizzy (fzy) encodes WD40 domain protein required for the full ubiquitin ligase activity of the anaphase-promoting complex/cyclosome (APC/C) in mitosis and meiosis. The product of fzy functions to target substrates for destruction and drive metaphase and anaphase transition. (526 aa) |
| | Grip71 | Grip71; Gamma-tubulin binding. It is involved in the biological process described with: centrosome cycle; protein localization to centrosome; regulation of cell cycle; spindle assembly involved in female meiosis I; mitotic cell cycle. (646 aa) |
| | CG10132 | GH25853p. (1361 aa) |
| | vls | Protein valois; Involved in specific localization of cytoplasmic proteins during the formation of pole plasm. Required for synthesis and/or stability of oskar protein (osk) and localization of tudor (tud) in both the nuage and posterior pole of the oocyte. Required for normal posterior localization of osk in later stages of oogenesis and for posterior localization of the vasa (vas) protein during the entire process of pole plasm assembly. May act by regulating the complex that contains the arginine N-methyltransferase csul. (367 aa) |
| | tex | Tex protein; It is involved in the biological process described with: mRNA export from nucleus. (320 aa) |
| | Vps15 | Vacuolar protein sorting 15 (Vps15) encodes a serine/threonine protein kinase that is a core component of the Vps34/class III PI3-Kinase complex. It is required for the production of PI3P and influences multiple vesicle trafficking pathways, including autophagy and endocytosis. (1342 aa) |
| | CG9467 | LD44003p; Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. It is involved in the biological process described with: protein homooligomerization; oxidation-reduction process. (730 aa) |
| | CG3909 | WD_REPEATS_REGION domain-containing protein. (331 aa) |
| | CG14722 | WD repeat-containing protein 55 homolog; It is involved in the biological process described with: defense response to Gram-negative bacterium; Belongs to the WD repeat WDR55 family. (498 aa) |
| | CG9799 | LD47749p; It is involved in the biological process described with: rRNA processing. (922 aa) |
| | Caf1-55 | Probable histone-binding protein Caf1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the nucleosome remodeling and deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylati [...] (430 aa) |
| | CG10185 | WD_REPEATS_REGION domain-containing protein; It is involved in the biological process described with: rRNA processing; regulation of DNA-dependent DNA replication initiation. (1732 aa) |
| | CG8064 | GH01043p; snoRNA binding. It is involved in the biological process described with: maturation of SSU-rRNA. (922 aa) |
| | Nup43 | Nucleoporin 43kD; It is involved in the biological process described with: mitotic cell cycle. (358 aa) |
| | Wdr37 | GH17724p. (487 aa) |
| | CG14285 | WD_REPEATS_REGION domain-containing protein. (297 aa) |
| | CG6015 | LD21931p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (576 aa) |
| | wda | Will decrease acetylation (wda) encodes a component of the highly conserved Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex. This complex is responsible for acetylation of histones and deubiquitination of the product of His2B at active promoters. The product of wda is a component of the histone-acetyltransferase (HAT) module, and is essential for full HAT activity of the the product of Gcn5. (743 aa) |
| | BRWD3 | BRWD3 (BRWD3) encodes a member of the Bromodomain and WD repeat_containing protein (BRWD) family. It regulates ecdysone and JAK-STAT signaling pathways and contributes to eye development, cell death and phagocytosis. (2232 aa) |
| | CG1523 | DDB1- and CUL4-associated factor 10 homolog; Belongs to the WD repeat DCAF10 family. (621 aa) |
| | CstF50 | Cleavage stimulation factor 50 kD subunit. (424 aa) |
| | SCAP | SREBP cleavage activating protein; Sterol binding. It is involved in the biological process described with: sterol regulatory element binding protein cleavage; protein processing; SREBP signaling pathway. (1276 aa) |
| | CG9945 | DDB1- and CUL4-associated factor 11 homolog; It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; Belongs to the WD repeat LEC14B family. (511 aa) |
| | rig | Rigor mortis (rig) encodes a component of the cytoplasmic U snRNP body and a member of the SMN-Gemins complex. It is required in the motor system for viability and motor behaviour. It also works as a nuclear receptor interacting protein required for ecdysone signalling during larval development. (1235 aa) |
| | Oseg6 | Outer segment 6; It is involved in the biological process described with: intraciliary retrograde transport; cilium assembly; non-motile cilium assembly. (1366 aa) |
| | CG30116 | Uncharacterized protein, isoform A. (1922 aa) |
| | Prp19 | Pre-RNA processing factor 19 (Prp19) encodes a protein involved in chromatin organization and alternative mRNA splicing regulation. (505 aa) |
| | adp | Adipose, isoform A; Adipose (adp) encodes a protein involved in lipid metabolism and fat storage. (628 aa) |
| | Dark | Death-associated APAF1-related killer, isoform B; Death-associated APAF1-related killer (Dark) encodes an essential component of the apoptosome. The products of Dark and Dronc form a pivotal holoenzyme required for apoptotic cell death with the products of Dark acting as an adaptor of the multimeric complex. (1440 aa) |
| | CG15701 | RE36115p; Dynein heavy chain binding; dynein light chain binding. It is involved in the biological process described with: microtubule-based movement; positive regulation of ATP-dependent microtubule motor activity, plus-end-directed; transport along microtubule. (1051 aa) |
| | wcd | U3 small nucleolar RNA-associated protein 18 homolog; Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA. Regulation of cell size by ribosome synthesis is an important parameter for stem cell maintenance and function; Belongs to the WD repeat UTP18 family. (506 aa) |
| | Ciao1 | Probable cytosolic iron-sulfur protein assembly protein Ciao1; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins. (335 aa) |
| | Ctf4 | Chromosome transmission fidelity 4; Chromatin binding. (895 aa) |
| | CG13192 | IP10750p; It is involved in the biological process described with: social behavior. (323 aa) |
| | Elp2 | Probable elongator complex protein 2; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in the regulation of the STAT pathway ; Belongs to the WD repeat ELP2 family. (794 aa) |
| | nclb | Periodic tryptophan protein 1 homolog; Chromatin-associated factor that regulates transcription. Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription. Regulates the localization to the nucleolus of Cdk7, a regulator of the Pol I- elongation factor TFIIH. Acts as regulator of cell proliferation and tissue growth as part of the TORC1 and Myc signaling pathway in response to nutrients. Required in males for both germline stem cell (GSC) maintenance and early stages of germ cell differentiation of germ cell cysts. Not required for female germline stem cell [...] (459 aa) |
| | Taf5 | Transcription initiation factor TFIID subunit 5; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in helping to anchor Taf4 within the TFIID complex. May be involved in transducing signals from various transcriptional regulators to the RNA polymerase II transcription machinery; Belongs to the WD repeat TAF5 family. (704 aa) |
| | Caf1-105 | Chromatin assembly factor 1, p105 subunit (Caf1-105) encodes one of the three subunits of Drosophila chromatin assembly factor 1 (CAF-1). It binds to histones and contributes to heterochromatin formation and maintenance, chromatin assembly, and developmental signal transduction such the Notch signaling pathway. (747 aa) |
| | CG1671 | LD47550p; U3 snoRNA binding. It is involved in the biological process described with: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (787 aa) |
| | CG12134 | RE62785p. (411 aa) |
| | CG10459 | Uncharacterized protein. (322 aa) |
| | CG30349 | FI03455p. (620 aa) |
| | Nup44A | Nucleoporin seh1; Probable component of the nuclear pore complex (NPC) (By similarity). Involved in maintaining the localization of another nucleoporin Mtor to the nuclear envelope of early meiotic female germline cells. It is not involved in recruiting the nucleoporins Mtor, Nup107, Nup153 and FG-containing nucleoporins to the NPC ; Belongs to the WD repeat SEC13 family. (354 aa) |
| | sw | Cytoplasmic dynein 1 intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the help dynein bind to dynactin 150 kDa component (By similarity). (663 aa) |
| | CG10931 | IP10415p; Histone methyltransferase activity (H3-K4 specific). It is involved in the biological process described with: histone H3-K4 methylation; histone H3 acetylation. (345 aa) |
| | CG5033 | Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family. (784 aa) |
| | Sdic1 | Sperm-specific dynein intermediate chain 1, isoform A; Dynein light chain binding; dynein heavy chain binding. It is involved in the biological process described with: positive regulation of ATP-dependent microtubule motor activity, plus-end-directed; microtubule-based movement. (517 aa) |
| | Lis-1 | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division, mitotic spindle formation and the removal of mitotic checkpoint proteins from kinetochores at the metaphase to anaphase transition. Required for several aspects of neurogenesis including neuroblast proliferation, neuronal cell differentiation, dendritic growth, b [...] (411 aa) |
| | gro | Groucho (gro) encodes a global developmental co-repressor in conjunction with manifold DNA-binding repressor partner proteins, which tether it to target promoters. It functions downstream of key signaling pathways such as Wg/Wnt and Dpp/TGF-beta. Notably, phosphorylation of the product of gro in response to MAPK activation weakens its repressor capacity. (730 aa) |
| | Gbeta13F | Guanine nucleotide-binding protein subunit beta-1; G protein beta-subunit 13F (Gbeta13F) encodes an ubiquitous, maternal product required for gastrulation movements of early embryo and regulating medial (mesoderm and ectoderm) and junctional Myosin II (ectoderm) via RhoI pathway. The product of Gbeta13F is detected apically and at adherens junctions. (340 aa) |
| | U3-55K | U3 small nuclear riboprotein factor 55K; RNA binding; snoRNA binding; U3 snoRNA binding. It is involved in the biological process described with: rRNA processing. (484 aa) |
| | CG33969 | RE11703p; It is involved in the biological process described with: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. (410 aa) |
| | CG34124 | FI23230p1; It is involved in the biological process described with: cilium assembly; cilium-dependent cell motility; sperm axoneme assembly. (2003 aa) |
| | wmd | Wing morphogenesis defect (wmd) encodes an essential WD-repeat protein that is required for wing development and motor behavior. (328 aa) |
| | l(2)05287 | Lethal (2) 05287. (1071 aa) |
| | Oseg5 | Outer segment 5; It is involved in the biological process described with: non-motile cilium assembly; cilium assembly. (775 aa) |
| | CG42233 | WD_REPEATS_REGION domain-containing protein. (773 aa) |
| | CG34133 | RE64336p; Rab GTPase binding. (1108 aa) |
| | CG7611 | WD repeat-containing protein 26 homolog; G-beta-like protein involved in cell signal transduction (By similarity). (630 aa) |
| | CG13137 | Uncharacterized protein; It is involved in the biological process described with: nucleocytoplasmic transport. (440 aa) |
| | CG42588 | Uncharacterized protein, isoform A; It is involved in the biological process described with: transcription by RNA polymerase III. (2730 aa) |
| | l(2)k09848 | Lethal (2) k09848, isoform A; It is involved in the biological process described with: muscle cell cellular homeostasis; ribosomal large subunit biogenesis. (419 aa) |
| | Rbcn-3A | Rabconnectin-3A (Rbcn-3A) encodes a protein that is part of a regulatory subunit of the Vacuolar H[+] ATPase required for acidification of intracellular vesicles and the lysosome. It is involved in endocytic trafficking and lysosome function, and mutations block Notch signaling in follicle cells and imaginal disc cells. (3426 aa) |
| | mv | Mauve (mv) encodes a member of the family of beige and Chediak-Higashi syndrome (BEACH)-domain containing proteins. Proteins in this family function to restrain the size of lysosomes and lysosome-related organelles. (3535 aa) |
| | Smu1 | Smu1 spliceosomal factor (Smu1) encodes a spliceosomal protein required for normal neuromuscular junction development and function. It functions together with the product of beag. Both proteins can regulate synaptic levels of the product of Fas2. (509 aa) |
| | Cka | Connector of kinase to AP-1, isoform E; Protein binding. (749 aa) |
| | l(2)gl | Lethal(2) giant larvae protein; Essential for the development of polarized epithelia, for cell polarity associated with asymmetric cell division of neuroblasts during development, and for oocyte polarity formation. Promotes the formation of actin-rich projections at the oocyte cortex and the posterior enrichment of par-1 which is required for oocyte polarization. Regulates the localization of axis-specifying morphogens such as stau and grk. [Isoform p127]: Has an accessory function in control of cell proliferation and differentiation during development. (1161 aa) |
| | CG43367 | Uncharacterized protein, isoform C. (2754 aa) |
| | CG33172 | MIP10235p; RNA binding. It is involved in the biological process described with: negative regulation of cell population proliferation. (998 aa) |
| | pod1 | Coronin; Pod1 (pod1) encodes a microtubule and actin filament binding protein involved in actin cytoskeleton reorganization and axon guidance; Belongs to the WD repeat coronin family. (1266 aa) |
| | wds | Protein will die slowly; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. (361 aa) |
| | CG5114 | Uncharacterized protein, isoform B. (445 aa) |
| | Poc1 | Proteome of centrioles 1 (Poc1) encodes a cytoplasmic protein located in the sperm giant centriole and proximal centriole-like structure (PCL), which assists in the elongation of the giant centrioles and recruitment of centriolar proteins to the PCL. It contributes to sperm motility and fertility. (403 aa) |
| | Atg18a | Autophagy-related 18a (Atg18a) encodes a protein that regulates autophagy by participating in isolation membrane elongation around cytoplasmic cargoes. (447 aa) |
| | slmb | Supernumerary limbs (slmb) encodes an essential, conserved F-box protein and a component of the SCF (Skp/Cullin/F-box) E3 ubiquitin-ligase, providing substrate specificity to the SCF. It negatively regulates multiple signaling pathways and cellular processes by promoting the proteasome-mediated degradation or cleavage of its targets, including the products of arm and ci (Wg and Hh signaling), SAK, per and Cap-H2. (597 aa) |
| | CG7568 | Uncharacterized protein, isoform E. (482 aa) |
| | Wdr24 | GATOR complex protein WDR24; An essential component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. GATOR2 activates the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyt [...] (777 aa) |
| | DCX-EMAP | Echinoderm microtubule-associated protein-like CG42247; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. (1118 aa) |
| | Rack1 | Guanine nucleotide-binding protein subunit beta-like protein; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity). (318 aa) |
| | CG14322 | Uncharacterized protein, isoform B; Ubiquitin binding. It is involved in the biological process described with: protein polyubiquitination. (1597 aa) |
| | Atg18b | Autophagy-related 18b, isoform A; Phosphatidylinositol-3-phosphate binding; phosphatidylinositol-3,5-bisphosphate binding. (471 aa) |
| | Nup37 | Nucleoporin Nup37; As part of the nuclear pore complex (NPC), has a role in its assembly and function. (320 aa) |
| | CG9062 | WD repeat-containing protein 48 homolog; Regulator of deubiquitinating complexes. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (By similarity). (680 aa) |
| | Oseg2 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. Belongs to the IFT172 family. (1754 aa) |
| | Dnai2 | Dynein, axonemal, intermediate chain 2 (Dnai2) encodes a subunit of the axonemal dynein complex. It is involved in the perception of sound and sperm competititon. (585 aa) |
| | Wdr62 | WD repeat domain 62 (Wdr62) encodes a protein involved in mitosis regulation. (2397 aa) |
| | l(3)72Dn | Lethal (3) 72Dn, isoform B; It is involved in the biological process described with: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (699 aa) |
| | Tusp | Tusp, isoform F; Tusp (Tusp) encodes a protein involved in SNARE complex assembly; Belongs to the TUB family. (1433 aa) |
| | l(2)09851 | Lethal (2) 09851, isoform A. (456 aa) |
| | DCAF12 | DDB1 and CUL4 associated factor 12, isoform A; It is involved in the biological process described with: regulation of programmed cell death; salivary gland cell autophagic cell death. (459 aa) |
| | coro | Coronin; Actin filament binding. It is involved in the biological process described with: defense response to fungus; actin filament organization; adult somatic muscle development; Belongs to the WD repeat coronin family. (535 aa) |
| | CG11975 | LD32381p; Phosphatidylinositol-3-phosphate binding; phosphatidylinositol-3,5-bisphosphate binding. It is involved in the biological process described with: autophagy of nucleus; protein lipidation; autophagy of mitochondrion; protein localization to phagophore assembly site; autophagosome assembly. (340 aa) |
| | Atg16 | Autophagy-related 16 (Atg16) encodes a protein that forms an E3-like protein complex. This complex contributes to the the covalent binding of the lipid phosphatidylethanolamine to the product of Atg8a, a key autophagy protein involved in autophagosome biogenesis. The product of Atg16 is involved in autophagosome biogenesis, maintenance of proper neuromuscular function, lifespan, ethanol sedation, and enteroendocrine cell function in the intestine. (612 aa) |
| | Bub3 | Bub3, isoform A; Bub3 (Bub3) encodes a protein that functions in the spindle assembly checkpoint (SAC) pathway. This mitotic checkpoint pathway inhibits the APC/C complex and hence the transition from metaphase to anaphase, as long as there are free kinetochores that are not yet attached to the mitotic spindle in the cell. The product of Bub3 is localized at the kinetochore during mitosis with maximal levels observed at free kinetochores. Together with other SAC proteins it forms mitotic checkpoint complexes that bind and inhibit the APC/C. (326 aa) |
| | CG6420 | AT02583p. (909 aa) |
| | wap | Wings apart (wap) encodes a protein required for growth, viability, muscle development, and proper wing venation. It physically interacts with the product of ds, and functions in the Hippo pathway to regulate growth. (343 aa) |
| | Aladin | Aladin; Involved in mitotic spindle assembly. (466 aa) |
| | CG3436 | GM13767p; RNA binding. It is involved in the biological process described with: mRNA splicing, via spliceosome; mitotic cell cycle. (347 aa) |
| | CG9313 | Uncharacterized protein, isoform B; Dynein light chain binding; dynein heavy chain binding. It is involved in the biological process described with: cilium movement; outer dynein arm assembly; microtubule-based movement; sensory perception of sound. (740 aa) |
| | Wdr59 | GATOR complex protein Wdr59; A component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the TORC1 signaling pathway. The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation. GATOR2 activates the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation and growth under nutrient replete conditions and during female oocyte development. (969 aa) |
| | Plap | Phospholipase A2 activator protein, isoform A; Ubiquitin binding. It is involved in the biological process described with: proteasome-mediated ubiquitin-dependent protein catabolic process; ubiquitin recycling. (787 aa) |
| | lt | Vacuolar protein sorting-associated protein 41 homolog; Light (lt) encodes a cellular-protein trafficking protein that forms part of the homotypic fusion and vacuolar protein sorting (HOPS) and class C core vacuole/endosome tethering (CORVET) complexes. It is required for fusion of autophagosomes with lysosomes, endocytic down-regulation of Notch signaling, and eye pigment biogenesis; Belongs to the VPS41 family. (841 aa) |
| | Rbcn-3B | Rabconnectin-3B, isoform A; Rabconnectin-3B (Rbcn-3B) encodes a protein that is part of a regulatory subunit of the Vacuolar H[+] ATPase required for acidification of intracellular vesicles and the lysosome. It involved in endocytic trafficking and lysosome function, and mutations block Notch signaling in follicle cells and imaginal disc cells. (1525 aa) |
| | rg | Neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways. Required for associative odor learning and short-term memory. Involved in development of the neuromuscular junction and the mushroom body. Belongs to the WD repeat neurobeachin family. (3785 aa) |
| | Oseg1 | Outer segment 1 (Oseg1) encodes a protein required for ciliogenesis. (1169 aa) |
| | tws | Protein phosphatase PP2A 55 kDa regulatory subunit; Could perform a substrate recognition function or could be responsible for targeting the enzyme complex to the appropriate subcellular compartment. (499 aa) |
| | Sec31 | Secretory 31 (Sec31) encodes a protein involved in the innate immune response. (1260 aa) |
| | CG11141 | WD repeat-containing protein CG11141; Belongs to the WD repeat KIAA0329 family. (710 aa) |
| | raptor | Raptor, isoform B; Raptor (raptor) encodes a crucial component of target of rapamycin (TOR) complex 1, which is a conserved regulator of cell growth and metabolism. (1621 aa) |
| | Sdic2 | Sperm-specific dynein intermediate chain 2, isoform A; Dynein light chain binding; dynein heavy chain binding. It is involved in the biological process described with: positive regulation of ATP-dependent microtubule motor activity, plus-end-directed; microtubule-based movement. (543 aa) |
| | CG12325 | LD10780p; It is involved in the biological process described with: ribosomal small subunit assembly; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). (949 aa) |
| | Sec13 | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II. Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development. Required for reactivation of transcription after heat shock. Required for nuclear import of phosphorylated Mad via importin msk. Has no role i [...] (356 aa) |
| | WDR79 | Telomerase Cajal body protein 1 homolog; RNA chaperone that plays a key role in Cajal body formation. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs). Probably acts by mediating localization of scaRNAs to Cajal bodies. (543 aa) |
| | Sdic3 | Sperm-specific dynein intermediate chain 3, isoform E; It is involved in the biological process described with: microtubule-based movement. (533 aa) |
| | thoc6 | THO complex subunit 6; The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress. Belongs to the WD repeat THOC6 family. (350 aa) |
| | WDY | WD repeat-containing protein on Y chromosome; Histone binding. It is involved in the biological process described with: histone H3-K4 methylation. (1069 aa) |
| | p | Hermansky-Pudlak syndrome 5 protein homolog; Has a role in the biogenesis of eye pigment granules. Eye pigment granules are specialized forms of late endosomes or lysosomes. Biogenesis of pigment granules in the eye requires molecular components required for protein delivery to lysosomes. (826 aa) |
| | SdicC | Dynein light chain binding; dynein heavy chain binding. It is involved in the biological process described with: microtubule-based movement; transport along microtubule; positive regulation of ATP-dependent microtubule motor activity, plus-end-directed. (544 aa) |
| | SdicB | It is involved in the biological process described with: microtubule-based movement. (533 aa) |
| | SdicA | It is involved in the biological process described with: microtubule-based movement. (533 aa) |
