STRINGSTRING
cwo cwo FBgn0002734 FBgn0002734 FBgn0002735 FBgn0002735 E(spl)m3-HLH E(spl)m3-HLH E(spl)m7-HLH E(spl)m7-HLH E(spl)m8-HLH E(spl)m8-HLH E(spl)m5-HLH E(spl)m5-HLH FBgn0002733 FBgn0002733 dpn dpn Hey Hey h h
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cwoTranscription factor cwo; Plays a role in the regulation of circadian rhythms. Transcriptional repressor which inhibits Clock-mediated transcriptional activation by binding to E boxes in the promoters of Clock target genes and repressing their transcription. E box binding activity is time- dependent with higher binding activity seen in the early morning (zeitgeber time 2) than early evening (zeitgeber time 14) and is dependent on the presence of the circadian protein per. It is likely that per binds to Clock-cycle heterodimers, reducing their affinity for E box binding and allowing cwo [...] (698 aa)
FBgn0002734Enhancer of split mdelta protein; Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity). May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes. Contributes to the neural-epidermal lineage decision during early neurogenesis. As part of the Notch signaling pathway, required to maintain the self-renewal and identity of type II neuroblasts by regulating the expression of the transcriptional repressor erm. (173 aa)
FBgn0002735Enhancer of split mgamma protein; Transcriptional repressor of genes that require a bHLH protein for their transcription. May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes. Contributes to the neural-epidermal lineage decision during early neurogenesis. Part of the Notch signaling pathway, plays a role in neuroblasts proliferation in embryos and larvae. In the larval brain, together with other self-renewal transcriptional repressors such as klu and dpn, required for type II neuroblast self-renewal and for maintaining erm in an inactive state in intermedi [...] (205 aa)
E(spl)m3-HLHEnhancer of split m3 protein; Transcriptional repressor of genes that require a bHLH protein for their transcription. May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes. Belongs to notch signaling pathway and depends on Su(H) for transcriptional activation. (224 aa)
E(spl)m7-HLHEnhancer of split m7 protein; Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. (186 aa)
E(spl)m8-HLHEnhancer of split m8 protein; Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. Part of the Notch signaling pathway. (179 aa)
E(spl)m5-HLHEnhancer of split m5 protein; Participates in the control of cell fate choice by uncommitted neuroectodermal cells in the embryo. Transcriptional repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'. (178 aa)
FBgn0002733Enhancer of split mbeta protein; Transcriptional repressor of genes that require a bHLH protein for their transcription (By similarity). May serve as a transcriptional regulator of the Achaete-scute complex (AS-C) genes. Contributes to the neural-epidermal lineage decision during early neurogenesis. Part of the Notch signaling pathway. (195 aa)
dpnProtein deadpan; Transcriptional repressor of genes that require a bHLH protein for their transcription. In the larval brain, required to maintain the self- renewal and identity of type II neuroblasts by regulating the expression of the transcriptional repressor erm together with other self-renewal transcriptional repressors such as klu and E(spl)mgamma- HLH. As part of its role in neuroblasts development, has been shown to be a direct target of the Notch signaling pathway, however might work also independently of N/Notch. In the developing larval and pupal brain, required for mushroom [...] (435 aa)
HeyHairy/E(spl)-related with YRPW motif (Hey) encodes a transcription factor involved in neuron fate determination. Hey expression is regulated by Notch signalling in the embryonic and larval central nervous system. (425 aa)
hHairy (h) encodes a bHLH transcriptional repressor that recruits the corepressor encoded by gro to target promoters. It is a pair-rule gene that contributes to embryonic segmentation and peripheral neurogenesis. (337 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.