STRINGSTRING
PGRP-LA PGRP-LA PGRP-LF PGRP-LF PGRP-SC1a PGRP-SC1a PGRP-LC PGRP-LC PGRP-LD PGRP-LD PGRP-SB2 PGRP-SB2 PGRP-SC1b PGRP-SC1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PGRP-LAPeptidoglycan-recognition protein LA; Peptidoglycan-recognition protein probably involved in innate immunity by binding to peptidoglycans (PGN) of bacteria and activating the immune response. (368 aa)
PGRP-LFPeptidoglycan recognition protein LF (PGRP-LF) encodes a transmembrane receptor that prevents the spontaneous activation of the immune deficiency pathway receptor encoded by PGRP-LC. (369 aa)
PGRP-SC1aPeptidoglycan-recognition protein SC1a; N-acetylmuramyl-L-alanine amidase involved in innate immunity by degrading bacterial peptidoglycans (PGN). Plays a scavenger role by digesting biologically active PGN into biologically inactive fragments. Has no direct bacteriolytic activity; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (185 aa)
PGRP-LCPeptidoglycan-recognition protein LC; Major activator of the imd/Relish pathway and is likely to encode a pattern recognition molecule for the humoral immune response. Required for Relish processing and nuclear translocation following proteolytic cleavage. Involved in the response to lipopolysaccharide (LPS) and peptidoglycan of Gram-negative bacteria. The different isoforms probably display different recognition capabilities to various microbial patterns. [Isoform x]: Mediates the response to LPS, peptidoglycan and Gram-negative bacteria; Belongs to the N-acetylmuramoyl-L-alanine amid [...] (520 aa)
PGRP-LDPeptidoglycan-recognition protein LD; Peptidoglycan-recognition protein probably involved in innate immunity by binding to peptidoglycans (PGN) of bacteria and activating the immune response; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. (327 aa)
PGRP-SB2Peptidoglycan recognition protein SB2 (PGRP-SB2) encodes a secreted peptidoglycan recognition protein (PGRP) with amidase activity against DAP-type peptidoglycan, a cell wall component found on Gram-negative bacteria and certain Gram positive bacteria. It is strongly induced upon bacterial infection by the immune deficiency pathway, suggesting a role as an immune effector. (191 aa)
PGRP-SC1bPeptidoglycan recognition protein SC1b (PGRP-SC1b) encodes a secreted peptidoglycan recognition protein (PGRP) with amidase activity against peptidoglycans. (185 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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