STRINGSTRING
CG12375 CG12375 Cpsf100 Cpsf100 CG30022 CG30022 RNaseZ RNaseZ IntS11 IntS11 tzn tzn Snm1 Snm1 CG9117 CG9117 Cpsf73 Cpsf73
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
CG12375Beta-lactamase-like protein 2 homolog; Single-stranded RNA binding; endoribonuclease activity; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. (292 aa)
Cpsf100Probable cleavage and polyadenylation specificity factor subunit 2; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Required for the cotranscriptional processing of 3'- ends of polyadenylated and histone pre-mRNA. (756 aa)
CG30022RE56416p; Sulfur dioxygenase activity; iron ion binding; hydrolase activity, acting on ester bonds. It is involved in the biological process described with: hydrogen sulfide metabolic process; glutathione metabolic process. (279 aa)
RNaseZRibonuclease Z, mitochondrial; Ribonuclease Z (RNaseZ) is a highly conserved gene that encodes the endoribonuclease RNase Z, which cleaves pre-tRNA molecules directly 3' to the discriminator. It has at least two biological roles - nuclear pre-tRNA processing and mitochondrial primary transcript processing. (766 aa)
IntS11Integrator complex subunit 11; Catalytic component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing (By similarity). Mediates the snRNAs 3' cleavage (By similarity). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5. May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity); Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. INT [...] (597 aa)
tznTenzing norgay, isoform C; Hydroxyacylglutathione hydrolase activity. It is involved in the biological process described with: methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; response to hypoxia. (348 aa)
Snm1LD28027p; 5'-3' exodeoxyribonuclease activity; damaged DNA binding. It is involved in the biological process described with: double-strand break repair via nonhomologous end joining; protection from non-homologous end joining at telomere; interstrand cross-link repair. (763 aa)
CG9117FI02812p. (228 aa)
Cpsf73Cleavage and polyadenylation specificity factor 73; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity and functions as mRNA 3'- end-processing endonuclease. Required for the cotranscriptional processing of 3'-ends of polyadenylated and histone pre-mRNA. Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lacta [...] (684 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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