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Hmt4-20 Hmt4-20 trr trr Smyd3 Smyd3 CG9149 CG9149 Set2 Set2 Aldh7A1 Aldh7A1 CG7430 CG7430 Plod Plod CG31915 CG31915 CG9547 CG9547 Aldh Aldh Mtpalpha Mtpalpha CG31751 CG31751 CG5214 CG5214 PR-Set7 PR-Set7 trx trx CG4335 CG4335 NSD NSD CG1544 CG1544 Echs1 Echs1 CG10814 CG10814 egg egg CG4565 CG4565 Set1 Set1 CG5321 CG5321 gpp gpp ash1 ash1 CG31075 CG31075 Su(var)3-9 Su(var)3-9 G9a G9a E(z) E(z) CG10947 CG10947 LKRSDH LKRSDH CG10932 CG10932
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Hmt4-20Histone-lysine N-methyltransferase Suv4-20; Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. Acts as a dominant suppressor of position-effect variegation; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily. (1300 aa)
trrHistone-lysine N-methyltransferase trr; Histone methyltransferase that acts as a coactivator for the ecdysone receptor during development. Specifically trimethylates 'Lys- 4' of histone H3, a specific tag for epigenetic transcriptional activation. Recruited by EcR in an ecdysone-dependent manner causing H3 'Lys-4' trimethylation at ecdysone-inducible promoters, leading to activate expression. Plays a central role in the developing compound eye, during the progression of the morphogenetic furrow and in post- furrow differentiation of the retinal epithelium, notably by activating express [...] (2431 aa)
Smyd3SET and MYND domain containing, class 3; Histone-lysine N-methyltransferase activity; protein-lysine N-methyltransferase activity. It is involved in the biological process described with: histone lysine methylation. (468 aa)
CG9149Uncharacterized protein; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
Set2Probable histone-lysine N-methyltransferase CG1716; Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity). (2362 aa)
Aldh7A1Aldehyde dehydrogenase 7 family member A1; Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. It is involved in the biological process described with: oxidation-reduction process. (540 aa)
CG7430Flavin adenine dinucleotide binding; dihydrolipoyl dehydrogenase activity; electron transfer activity. It is involved in the biological process described with: tricarboxylic acid cycle; lipoamide metabolic process; oxidation-reduction process; glycine catabolic process; cell redox homeostasis. (504 aa)
PlodProcollagen-lysine,2-oxoglutarate 5-dioxygenase; Procollagen lysyl hydroxylase (Plod) encodes a lysyl dehydrogenase with roles in Collagen IV biosynthesis. It localizes to the endoplasmic reticulum and is required for the secretion Collagen IV from haemocytes and fat body. (721 aa)
CG31915Glycosyltransferase 25 family member; Procollagen galactosyltransferase activity. (612 aa)
CG9547GH06693p; glutaryl-CoA dehydrogenase activity; flavin adenine dinucleotide binding; fatty-acyl-CoA binding. It is involved in the biological process described with: fatty acid beta-oxidation using acyl-CoA dehydrogenase; lysine catabolic process; hydroxylysine catabolic process; fatty-acyl-CoA biosynthetic process; tryptophan metabolic process. (419 aa)
AldhAldehyde dehydrogenase (Aldh) encodes an NAD[+] dependent mitochondrial aldehyde dehydrogenase. Its functions include detoxifying endogenous aldehydes generated by lipid peroxidation, and detoxifying acetaldehyde derived from dietary ethanol. (520 aa)
MtpalphaMitochondrial trifunctional protein alpha subunit (Mtpalpha) encodes a subunit of the mitochondrial trifunctional protein. It possesses 3-enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase activities, which catalyze the second and third steps,respectively, of the beta-oxidation of long-chain fatty acids. (783 aa)
CG31751FI20105p1; Amino acid kinase activity; hydroxylysine kinase activity. (417 aa)
CG5214GM01350p; Dihydrolipoyllysine-residue succinyltransferase activity. It is involved in the biological process described with: cellular respiration; tricarboxylic acid cycle. (468 aa)
PR-Set7Histone-lysine N-methyltransferase PR-Set7; Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4. H4 'Lys-20' monomethylation is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, possibly by contributing to the maintenance of proper higher-order structure of DNA and chromosome condensation during mitosis; Belongs to the class V-like SAM-binding methyltransferase superfa [...] (691 aa)
trxHistone-lysine N-methyltransferase trithorax; Histone methyltransferase that trimethylates 'Lys-9' of histone H3 (H3K9me3). H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional activation. Functions in segment determination through interaction with genes of bithorax (BX-C) and antennapedia (ANT-C) complexes. Acts as an activator of BX-C. Involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo. (3726 aa)
CG4335Uncharacterized protein; Trimethyllysine dioxygenase activity; iron ion binding. It is involved in the biological process described with: oxidation-reduction process; carnitine biosynthetic process. (364 aa)
NSDProbable histone-lysine N-methyltransferase Mes-4; Probable histone methyltransferase. Histone methylation gives specific tags for epigenetic transcriptional activation or repression (By similarity); Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. (1427 aa)
CG1544Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (919 aa)
Echs1Enoyl-CoA hydratase, short chain 1, isoform A; enoyl-CoA hydratase activity. It is involved in the biological process described with: fatty acid beta-oxidation; Belongs to the enoyl-CoA hydratase/isomerase family. (295 aa)
CG10814LP01339p; Gamma-butyrobetaine dioxygenase activity. It is involved in the biological process described with: carnitine biosynthetic process; oxidation-reduction process. (402 aa)
eggHistone-lysine N-methyltransferase eggless; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 in ovary. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Plays a central role during oogenesis; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (1262 aa)
CG4565Uncharacterized protein; Histone methyltransferase activity (H3-K36 specific); zinc ion binding. It is involved in the biological process described with: histone methylation; histone lysine methylation. (269 aa)
Set1Histone-lysine N-methyltransferase SETD1; Catalytic component of the SET1 complex that specifically di- and trimethylates 'Lys-4' of histone H3 and is the main di- and trimethyltransferase throughout development. Set1-dependent trimethylation regulates chromatin changes at active promoters that ensure optimal RNA polymerase II release into productive elongation, thereby contributing to optimal transcription. (1641 aa)
CG5321Uncharacterized protein, isoform B; Gamma-butyrobetaine dioxygenase activity. It is involved in the biological process described with: carnitine biosynthetic process; oxidation-reduction process. (413 aa)
gppHistone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase. Methylates 'Lys-79' of histone H3. Required for Polycomb Group (PcG) and trithorax Group (trxG) maintenance of expression. Also involved in telomeric silencing but do not in centric heterochromatin. Probably participates in pairing sensitivity. (2137 aa)
ash1Histone-lysine N-methyltransferase ash1; Trithorax group (TrxG) protein that has histone methyltransferase activity. Specifically trimethylates 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. TrxG proteins are generally required to maintain the transcriptionally active state of homeotic genes throughout development. Does not act as a coactivator required for transcriptional activation, but specifically prevents inappropriate Polycomb Group (PcG) silencing of homeotic genes in cells in which they must stay transcriptionally active. Belongs to t [...] (2226 aa)
CG31075Uncharacterized protein, isoform B; Aldehyde dehydrogenase (NAD+) activity. It is involved in the biological process described with: oxidation-reduction process; pyruvate metabolic process. (508 aa)
Su(var)3-9Histone-lysine N-methyltransferase Su(var)3-9; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting Su(var)205/HP1 to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric regions. Involved in heterochromatic gene silencing including the modification of position-effect-variegation. Belongs to the cl [...] (635 aa)
G9aG9a, isoform B; G9a (G9a) encodes a histone-lysine methyltransferase involved in epigenetic regulation. It contributes to multiple processes including gene expression, dendrite morphogenesis, larval locomotory behavior as well as short and long-term memory. (1657 aa)
E(z)Histone-lysine N-methyltransferase E(z); Polycomb group (PcG) protein. Catalytic subunit of the Esc/E(z) complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting [...] (765 aa)
CG10947FI04554p; S-adenosylmethionine-dependent methyltransferase activity; calmodulin-lysine N-methyltransferase activity. It is involved in the biological process described with: regulation of translation. (404 aa)
LKRSDHLysine ketoglutarate reductase/saccharopine dehydrogenase (LKRSDH) encodes a bifunctional enzyme that catalyzes the first two steps in the lysine degradation pathway. (928 aa)
CG10932LD24105p; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; fatty acid biosynthetic process; pyruvate metabolic process; Belongs to the thiolase-like superfamily. Thiolase family. (410 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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