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Cht11 Cht11 Hexo2 Hexo2 Hex-A Hex-A Cht8 Cht8 Cht9 Cht9 Cht4 Cht4 Cht12 Cht12 Gmer Gmer Gale Gale Cht7 Cht7 Hexo1 Hexo1 CG7914 CG7914 Pgm1 Pgm1 Pmm2 Pmm2 nst nst Uxs Uxs sgl sgl Gmd Gmd Oscillin Oscillin mmy mmy Galt Galt Mpi Mpi NANS NANS Cht5 Cht5 CG6218 CG6218 Hex-t1 Hex-t1 Hex-t2 Hex-t2 Gfat2 Gfat2 CG11257 CG11257 CG8207 CG8207 Hex-C Hex-C Pgm2b Pgm2b Pgm2a Pgm2a Pgi Pgi kkv kkv UGP UGP CG17065 CG17065 Gfat1 Gfat1 Cht2 Cht2 Cht6 Cht6 Gnpnat Gnpnat Cht10 Cht10 Chs2 Chs2 CG5946 CG5946 CG1129 CG1129 CG15771 CG15771 Csas Csas
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Cht11Chitinase activity; chitin binding. It is involved in the biological process described with: chitin catabolic process; carbohydrate metabolic process; Belongs to the glycosyl hydrolase 18 family. (432 aa)
Hexo2Beta-hexosaminidase; Hexosaminidase 2 (Hexo2) encodes a beta-N-acetylglucosaminidase involved in carbohydrate metabolism. (622 aa)
Hex-APhosphotransferase; Hexokinase A (Hex-A) encodes a hexokinase involved in glucose homeostasis. (541 aa)
Cht8Chitinase 8; Chitin binding; chitinase activity. It is involved in the biological process described with: carbohydrate metabolic process; ecdysis, chitin-based cuticle; chitin catabolic process; Belongs to the glycosyl hydrolase 18 family. (476 aa)
Cht9Chitinase 9 (Cht9) encodes an enzyme involved in the formation of chitin-based extracellular matrix at barrier tissues; Belongs to the glycosyl hydrolase 18 family. (368 aa)
Cht4Chitinase 4 (Cht4) encodes a chitin binding protein with chitinolytic activity; Belongs to the glycosyl hydrolase 18 family. (462 aa)
Cht12Chitinase 12 (Cht12) encodes an enzyme involved in cuticle development, ecdysis and wound healing; Belongs to the glycosyl hydrolase 18 family. (470 aa)
GmerProbable GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily. (321 aa)
GaleUDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP- Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconvers [...] (350 aa)
Cht7Chitinase 7 (Cht7) encodes an enzyme involved in cuticle development, ecdysis and wound healing; Belongs to the glycosyl hydrolase 18 family. (1013 aa)
Hexo1Beta-hexosaminidase; Hexosaminidase 1 (Hexo1) encodes a beta-N-acetylglucosaminidase involved in protein deglycosylation and rhodopsin biosynthesis. (622 aa)
CG7914FAD-binding FR-type domain-containing protein; Oxidoreductase activity. It is involved in the biological process described with: oxidation-reduction process. (315 aa)
Pgm1Phosphoglucomutase; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family. (560 aa)
Pmm2Probable phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. (254 aa)
nstNesthocker (nst) encodes a phospho-acetylglucosamine mutase, an essential enzyme in the biosynthetic pathway of N-Acetylglucosamine (GlcNAc). In the embryo, it is required for normal GlcNAc levels and affects Fibroblast-Growth-Factor signaling. (549 aa)
UxsUDP-xylose synthase; NAD+ binding; UDP-glucuronate decarboxylase activity. (441 aa)
sglUDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate and heparan sulfate. Required for wingless signaling in different tissues; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (476 aa)
GmdGDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (395 aa)
OscillinIdentical protein binding; glucosamine-6-phosphate deaminase activity. (273 aa)
mmyMummy, isoform A; Mummy (mmy) encodes an UDP-N-acetylglucosamine diphosphorylase. It functions in apical extracellular matrix formation by producing GlcNAc residues needed for chitin synthesis and protein glycosylation. It regulates cuticle production, tracheal morphogenesis, and axon guidance. (520 aa)
GaltGalactose-1-phosphate uridylyltransferase (Galt) encodes an enzyme that contributes to galactose homeostasis and adult locomotory behavior. (350 aa)
MpiZinc ion binding; mannose-6-phosphate isomerase activity. It is involved in the biological process described with: GDP-mannose biosynthetic process; carbohydrate metabolic process. (396 aa)
NANSSialic acid synthase; Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy- D-glycero-D-galacto-nononic acid (KDN). Can also use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. Essential for biosynthesis of sialic acids in neurons of the central nervous system. (372 aa)
Cht5Chitinase 5 (Cht5) encodes an enzyme involved in the formation of chitin-based extracellular matrix at barrier tissues; Belongs to the glycosyl hydrolase 18 family. (595 aa)
CG6218GH07590p; N-acetylglucosamine kinase activity. It is involved in the biological process described with: carbohydrate phosphorylation. (348 aa)
Hex-t1Hexokinase type 1; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate. (465 aa)
Hex-t2Hexokinase type 2; Catalyzes the phosphorylation of various hexoses to hexose 6- phosphate. (486 aa)
Gfat2Glutamine:fructose-6-phosphate aminotransferase 2; Glutamine-fructose-6-phosphate transaminase (isomerizing) activity; carbohydrate derivative binding. It is involved in the biological process described with: UDP-N-acetylglucosamine metabolic process; fructose 6-phosphate metabolic process; protein N-linked glycosylation. (683 aa)
CG11257FI21247p1; Cytochrome-b5 reductase activity, acting on NAD(P)H; heme binding. It is involved in the biological process described with: oxidation-reduction process; superoxide metabolic process; generation of precursor metabolites and energy. (535 aa)
CG8207RE21160p; Nucleotidyltransferase activity. It is involved in the biological process described with: biosynthetic process. (438 aa)
Hex-CPhosphotransferase; Hexokinase C (Hex-C) encodes a hexokinase involved in glucose homeostasis. (454 aa)
Pgm2bPhosphoglucomutase 2b; Intramolecular transferase activity, phosphotransferases. It is involved in the biological process described with: carbohydrate metabolic process. (628 aa)
Pgm2aPhosphoglucomutase 2a; Magnesium ion binding; intramolecular transferase activity, phosphotransferases. It is involved in the biological process described with: carbohydrate metabolic process. (623 aa)
PgiPhosphoglucose isomerase (Pgi) encodes an enzyme involved in glucose homeostasis. (558 aa)
kkvKrotzkopf verkehrt (kkv) encodes a membrane-inserted glycosyltransferase family 2 chitin synthase that uses GlcNAc to produce the polysaccharide chitin, which is extruded to the differentiating cuticle and tracheal system (tracheal cuticle, tube diameter regulation and gas filling). (1615 aa)
UGPUTP--glucose-1-phosphate uridylyltransferase; UGP (UGP) encodes an enzyme involved in hyperoxia response. (520 aa)
CG17065N-acetylglucosamine-6-phosphate deacetylase activity. It is involved in the biological process described with: N-acetylglucosamine catabolic process; Belongs to the metallo-dependent hydrolases superfamily. NagA family. (431 aa)
Gfat1Glutamine:fructose-6-phosphate aminotransferase 1, isoform A; Glutamine-fructose-6-phosphate transaminase (isomerizing) activity; carbohydrate derivative binding. It is involved in the biological process described with: carbohydrate derivative biosynthetic process. (694 aa)
Cht2Probable chitinase 2; Chitin binding; chitinase activity. (484 aa)
Cht6Chitinase 6 (Cht6) encodes an enzyme involved in ecdysis; Belongs to the glycosyl hydrolase 18 family. (4611 aa)
GnpnatMonosaccharide binding; N-acetyltransferase activity; glucosamine 6-phosphate N-acetyltransferase activity. It is involved in the biological process described with: UDP-N-acetylglucosamine biosynthetic process; Belongs to the acetyltransferase family. GNA1 subfamily. (228 aa)
Cht10Probable chitinase 10; Chitinase activity; chitin binding. It is involved in the biological process described with: carbohydrate metabolic process; chitin catabolic process. (2286 aa)
Chs2Chitin synthase activity. It is involved in the biological process described with: cuticle chitin biosynthetic process. (1393 aa)
CG5946FAD binding; cytochrome-b5 reductase activity, acting on NAD(P)H. It is involved in the biological process described with: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; regulation of lipid storage; oxidation-reduction process; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (330 aa)
CG1129Mannose-1-phosphate guanyltransferase beta; Mannose-1-phosphate guanylyltransferase activity. It is involved in the biological process described with: larval lymph gland hemopoiesis; biosynthetic process. (369 aa)
CG15771LD15807p; Hydrolase activity. (355 aa)
CsasCMP-sialic acid synthase; N-acylneuraminate cytidylyltransferase activity. It is involved in the biological process described with: response to heat; chemical synaptic transmission. (248 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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