STRINGSTRING
CG17896 CG17896 Ocrl Ocrl Mipp2 Mipp2 sktl sktl CG3530 CG3530 Pi3K59F Pi3K59F Sac1 Sac1 Pis Pis sl sl CG17026 CG17026 CG17028 CG17028 INPP5E INPP5E Pi3K68D Pi3K68D FIG4 FIG4 Ipk2 Ipk2 CG9389 CG9389 IP3K1 IP3K1 Ipp Ipp Tpi Tpi CG6805 CG6805 Inos Inos fab1 fab1 Pi4KIIalpha Pi4KIIalpha Plc21C Plc21C PIP4K PIP4K CG3632 CG3632 Ipk1 Ipk1 CG6910 CG6910 CG42271 CG42271 5PtaseI 5PtaseI Pten Pten norpA norpA PIP5K59B PIP5K59B CG9391 CG9391 Synj Synj CG9784 CG9784 Pi4KIIIalpha Pi4KIIIalpha CG17029 CG17029 CG17027 CG17027 Pi3K92E Pi3K92E EDTP EDTP mtm mtm Mipp1 Mipp1 IP3K2 IP3K2 fwd fwd
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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CG17896Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity). (520 aa)
OcrlOculocerebrorenal syndrome of Lowe (Ocrl) encodes an inositol polyphosphate 5-phosphatase that regulates PtdIns(4,5)P2 homeostasis by dephosphorylating PtdIns(4,5)P2 on endocytic compartments. In vitro experiments also suggest a role of the product of Ocrl during cytokinesis. (850 aa)
Mipp2Multiple inositol polyphosphate phosphatase 2; Acid phosphatase activity; inositol phosphate phosphatase activity; bisphosphoglycerate 3-phosphatase activity. It is involved in the biological process described with: TOR signaling; dephosphorylation. (453 aa)
sktlSkittles, isoform A; Skittles (sktl) encodes the major Phosphatidylinositol 4-Phosphate-5 kinase (PI4P5K), catalysing the formation of phosphoinositol-4,5-bisphosphate (PIP4,5). The sktl product is involved in many cellular processes involving (PIP4,5), such as endocytosis. It plays an important role in cell polarity by controlling the localization of the product encoded by baz. (792 aa)
CG3530GH09546p; Metal ion binding; phosphatidylinositol-3-phosphatase activity; protein tyrosine phosphatase activity; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity. It is involved in the biological process described with: phosphatidylinositol dephosphorylation; mitotic cell cycle; regulation of autophagy. (761 aa)
Pi3K59FPhosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. (949 aa)
Sac1Sac1 phosphatase (Sac1) encodes a lipid phosphatase that dephosphorylates phosphatidylinositol 4-phosphate to generate phosphatidylinositol. It is involved in dorsal closure, Hedgehog signaling and axon guidance. (592 aa)
PisCDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content (By similarity). The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (By similarity). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5- bisphosphate (PtdInsP2) from phosphatidic acid (PA) and maintenance of its steady supply during signaling, thus playing [...] (224 aa)
sl1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Small wing (sl) encodes a phosphatidylinositol-specific phospholiase type C that is required as a general modulator for growth downstream of the insulin pathway, and interacts with the Ras-MAPK pathway. (1236 aa)
CG17026Inositol-1-monophosphatase; Inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: inositol metabolic process; signal transduction; inositol phosphate dephosphorylation; phosphatidylinositol phosphorylation. (284 aa)
CG17028Inositol-1-monophosphatase; Inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: inositol phosphate dephosphorylation; phosphatidylinositol phosphorylation; signal transduction; inositol metabolic process. (284 aa)
INPP5EInositol polyphosphate 5-phosphatase E; Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) to phosphatidylinositol 4-phosphate (PI-4-P). By controlling the phosphoinositide composition of the cilia membrane of auditory receptor neurons, regulates the cilia localization of ktub and consequently the transient receptor potential channels iav and nompC. Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type IV family. (747 aa)
Pi3K68DPhosphotidylinositol 3 kinase 68D (Pi3K68D) encodes a phosphatidylinositol kinase involved in the organization of the cortical actin cytoskeleton and the regulation of the Egfr signaling pathway; Belongs to the PI3/PI4-kinase family. (1876 aa)
FIG4FIG4 phosphoinositide 5-phosphatase; Phosphoric ester hydrolase activity. It is involved in the biological process described with: larval locomotory behavior; regulation of lysosome size; compound eye morphogenesis. (858 aa)
Ipk2Kinase; Ipk2 (Ipk2) encodes a kinase involved in imaginal disc development and biosynthesis of inositol phosphate; Belongs to the inositol phosphokinase (IPK) family. (309 aa)
CG9389GH15479p; Inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: inositol metabolic process; signal transduction; inositol phosphate dephosphorylation; phosphatidylinositol phosphorylation. (596 aa)
IP3K1Kinase; Inositol 1,4,5-triphosphate kinase 1 (IP3K1) encodes a protein involved in response to oxidative stress; Belongs to the inositol phosphokinase (IPK) family. (441 aa)
IppInositol polyphosphate 1-phosphatase (Ipp) encodes a protein involved in synaptic transmission and inositol metabolism regulation. (375 aa)
TpiTriose phosphate isomerase (Tpi) encodes a soluble metabolic protein dimer that functions in glycolysis catalyzing the isomerization between dihydroxyacetone phosphate and glyceraldehyde 3-phosphate, which is essential for efficient ATP production. (348 aa)
CG6805LD06095p; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. It is involved in the biological process described with: positive regulation of flagellated sperm motility; phosphatidylinositol dephosphorylation; inositol phosphate dephosphorylation. (357 aa)
InosInositol-3-phosphate synthase activity. It is involved in the biological process described with: inositol biosynthetic process; phospholipid biosynthetic process. (565 aa)
fab1Putative 1-phosphatidylinositol 3-phosphate 5-kinase; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Has a role at a late stage in endosome- related membrane trafficking, at a point when signal termination has occurred. Is not required for receptor silencing. (1809 aa)
Pi4KIIalphaPi4KIIalpha, isoform A; Pi4KIIalpha (Pi4KIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. It contributes to membrane trafficking in the larval salivary gland. (710 aa)
Plc21C1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1318 aa)
PIP4KPhosphatidylinositol 5-phosphate 4-kinase (PIP4K) encodes an enzyme that mediates the conversion of phosphatidylinositol 4 phosphate to phosphatidylinositol 4,5 bisphosphate. It has been implicated in the regulation of mTOR signalling and control of cell size. (404 aa)
CG3632LD11744p; It is involved in the biological process described with: peptidyl-tyrosine dephosphorylation; phosphatidylinositol dephosphorylation; regulation of autophagy. (1250 aa)
Ipk1Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (716 aa)
CG6910RH44796p; Inositol oxygenase activity; iron ion binding. It is involved in the biological process described with: oxidation-reduction process; inositol catabolic process. (292 aa)
CG42271Uncharacterized protein, isoform C; Phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. (1280 aa)
5PtaseI5PtaseI, isoform C; Inositol-polyphosphate 5-phosphatase activity. It is involved in the biological process described with: inositol phosphate dephosphorylation; inositol phosphate-mediated signaling; phosphatidylinositol dephosphorylation. (699 aa)
PtenPhosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. (514 aa)
norpA1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...] (1095 aa)
PIP5K59BPhosphatidylinositol 4-phosphate 5-kinase at 59B, isoform E. (891 aa)
CG9391Inositol-1-monophosphatase; Inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: phosphatidylinositol phosphorylation; inositol phosphate dephosphorylation; inositol metabolic process; signal transduction. (278 aa)
SynjSynaptojanin, isoform A; Synaptojanin (Synj) encodes a synaptic Phosphoinositide phosphate (PtdInsP) phosphatase that catalyzes the hydrolysis of phosphate groups from phosphorylated inositols. It is recruited or stabilized by the product of EndoA to endocytic membranes, and it catalyzes dephosphorylation reactions implicated in the uncoating of nascent endocytic vesicles. When the product of Synj dephosphorylates phosphoinositides on nascent vesicles, endocytic adaptors with affinity for these lipids will leave the membrane to uncoat the vesicle. (1218 aa)
CG9784Uncharacterized protein, isoform C; Phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. It is involved in the biological process described with: positive regulation of flagellated sperm motility; phosphatidylinositol dephosphorylation; inositol phosphate dephosphorylation. (519 aa)
Pi4KIIIalphaPhosphatidylinositol 4-kinase III alpha (PI4KIIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. Its roles include localization of plasma membrane-associated cytoskeletal and membrane trafficking proteins, Hippo signaling regulation and polarization of developing oocytes; Belongs to the PI3/PI4-kinase family. (2154 aa)
CG17029Inositol-1-monophosphatase; Inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: inositol metabolic process; signal transduction; inositol phosphate dephosphorylation; phosphatidylinositol phosphorylation. (284 aa)
CG17027Inositol-1-monophosphatase; Inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: signal transduction; inositol metabolic process; inositol phosphate dephosphorylation; phosphatidylinositol phosphorylation. (288 aa)
Pi3K92EPhosphoinositide 3-kinase, Dp110; Pi3K92E (Pi3K92E) encodes the catalytic subunit of a class I phosphatidylinositol 3-kinase that functions downstream of the product of InR and other receptors during several processes, including cell and tissue growth; Belongs to the PI3/PI4-kinase family. (1088 aa)
EDTPEgg-derived tyrosine phosphatase, isoform C; Phosphatidylinositol-3-phosphatase activity; protein tyrosine phosphatase activity. It is involved in the biological process described with: dephosphorylation; oogenesis. (754 aa)
mtmMyotubularin, isoform A; Myotubularin (mtm) encodes a phosphatidylinositol-3-phosphatase that, together with the products of Sbf and Rab21, regulates macrophage protrusion formation. It is involved in cortical actin cytoskeleton organization, chromosome segregation and endocytic recycling. (619 aa)
Mipp1Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate (By similarity). Has a role in embryonic tracheal development where it localizes to the leading edge of actively migrating branches. In these leading cells, enhances formation [...] (467 aa)
IP3K2Kinase; Inositol 1,4,5-triphosphate kinase 2 (IP3K2) encodes a kinase that regulates calcium levels by influencing IP3 signaling; Belongs to the inositol phosphokinase (IPK) family. (691 aa)
fwdFour wheel drive (fwd) encodes a Golgi-localized lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. It is involved in spermatocyte cytokinesis and male fertility; Belongs to the PI3/PI4-kinase family. (1682 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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