STRINGSTRING
CG3009 CG3009 Paf-AHalpha Paf-AHalpha iPLA2-VIA iPLA2-VIA CG11437 CG11437 CG11426 CG11426 CG11425 CG11425 laza laza CG7149 CG7149 CG33116 CG33116 wun2 wun2 wun wun Lis-1 Lis-1 sPLA2 sPLA2 LPCAT LPCAT CG14507 CG14507 Pld Pld CG30503 CG30503 ADPS ADPS Kua Kua GXIVsPLA2 GXIVsPLA2 Pld3 Pld3 CG11438 CG11438 GIIIspla2 GIIIspla2 CG43345 CG43345
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CG3009RH14732p; Calcium-dependent phospholipase A2 activity. It is involved in the biological process described with: arachidonic acid secretion; phospholipid metabolic process. (342 aa)
Paf-AHalphaPlatelet-activating factor acetylhydrolase IB subunit beta homolog. (225 aa)
iPLA2-VIACalcium-independent phospholipase A2 VIA (iPLA2-VIA) encodes a protein that localizes to cytosol and mitochondria involved in repairing oxidized mitochondrial lipids, such as cardiolipin, and thus preventing cytochrome c release. It is partially responsible for cardiolipin depletion and monolysocardiolipin accumulation in Taz-deficient flies, which is a model of Barth syndrome. (887 aa)
CG11437RE35159p; Phosphatidate phosphatase activity; phosphatase activity; lipid phosphatase activity. It is involved in the biological process described with: phospholipid dephosphorylation; phospholipid metabolic process; signal transduction. (305 aa)
CG11426FI20175p1; Phosphatidate phosphatase activity; phosphatase activity; lipid phosphatase activity. It is involved in the biological process described with: signal transduction; phototransduction; phospholipid metabolic process; phospholipid dephosphorylation. (340 aa)
CG11425GH04282p; Lipid phosphatase activity; phosphatidate phosphatase activity; phosphatase activity. It is involved in the biological process described with: phospholipid dephosphorylation; phospholipid metabolic process; signal transduction. (305 aa)
lazaHL01743p; Lazaro (laza) encodes a protein involved in phototransduction, response to light intensity and thermotaxis. (334 aa)
CG7149GH11618p; Ethanolaminephosphotransferase activity; phosphotransferase activity, for other substituted phosphate groups. It is involved in the biological process described with: phosphatidylethanolamine biosynthetic process; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (415 aa)
CG33116FI05338p; Phosphotransferase activity, for other substituted phosphate groups; ethanolaminephosphotransferase activity. It is involved in the biological process described with: phosphatidylethanolamine biosynthetic process; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (427 aa)
wun2Wunen-2, isoform A; Wunen-2 (wun2) encodes a lipid phosphate phosphatase, an enzyme with an active site predicted to face extracellularly. It is required for germ cell migration and survival, acting partially redundantly with its paralog wun. (350 aa)
wunPutative phosphatidate phosphatase; Wunen (wun) encodes a lipid phosphate phosphatase with 6 transmembrane domains and an active site that is predicted to face extracellularly. It is required for germ cell migration and survival, septate junction function in the tracheal system and for heart formation; Belongs to the PA-phosphatase related phosphoesterase family. (379 aa)
Lis-1Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division, mitotic spindle formation and the removal of mitotic checkpoint proteins from kinetochores at the metaphase to anaphase transition. Required for several aspects of neurogenesis including neuroblast proliferation, neuronal cell differentiation, dendritic growth, b [...] (411 aa)
sPLA2Secretory phospholipase A2, isoform A; Calcium-dependent phospholipase A2 activity. It is involved in the biological process described with: arachidonic acid secretion; phospholipid metabolic process. (186 aa)
LPCATLysophosphatidylcholine acyltransferase; Acetyltransferase which mediates the conversion of 1-acyl-sn- glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC) (By similarity). Has a calcium-independent activity (By similarity). Displays a clear preference for saturated fatty acyl-CoAs, and 1- myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively (By similarity). Involved in the regulation of lipid droplet number and size. (533 aa)
CG14507Calcium ion binding; phospholipase A2 activity. It is involved in the biological process described with: arachidonic acid secretion; phospholipid metabolic process; lipid catabolic process. (373 aa)
PldPhospholipase; Phosphatidylinositol binding; phospholipase D activity. (1364 aa)
CG30503RH50933p; Calcium-dependent phospholipase A2 activity. It is involved in the biological process described with: arachidonic acid secretion; phospholipid metabolic process. (173 aa)
ADPSAlkyldihydroxyacetonephosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family. (631 aa)
KuaKua, isoform A. (310 aa)
GXIVsPLA2Group XIV secreted phospholipase A2; Calcium ion binding; phospholipase A2 activity. It is involved in the biological process described with: arachidonic acid secretion; phospholipid metabolic process; lipid catabolic process. (230 aa)
Pld3GM01519p; Catalytic activity. (494 aa)
CG11438RH32172p; Phosphatidate phosphatase activity; phosphatase activity; lipid phosphatase activity. It is involved in the biological process described with: phospholipid dephosphorylation; phospholipid metabolic process; signal transduction. (341 aa)
GIIIspla2Phospholipase A2 activity. It is involved in the biological process described with: arachidonic acid secretion; phospholipid metabolic process. (217 aa)
CG43345LD39232p1; Catalytic activity. (493 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.