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Shmt Shmt kdn kdn Spat Spat Gip Gip CG11291 CG11291 CG9149 CG9149 CG32487 CG32487 Cat Cat CG7430 CG7430 CG5567 CG5567 CG10749 CG10749 CG10748 CG10748 Gs1 Gs1 ppl ppl AcCoAS AcCoAS CG1236 CG1236 CG6415 CG6415 CG3999 CG3999 Irp-1B Irp-1B mAcon2 mAcon2 CG14740 CG14740 Mdh2 Mdh2 Irp-1A Irp-1A CG18003 CG18003 CG9886 CG9886 CG9314 CG9314 KFase KFase Gs2 Gs2 Mdh1 Mdh1 CG10932 CG10932 CG32488 CG32488 mAcon1 mAcon1 CG5577 CG5577
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ShmtSerine hydroxymethyl transferase (Shmt) encodes a conserved pyridoxal phosphate-containing enzyme that converts serine into glycine and N5,N10-methylentetrahydrofolate. This reaction represents a major source for activated C1 units and tetrahydrofolate-mediated C1 metabolism; Belongs to the SHMT family. (537 aa)
kdnProbable citrate synthase, mitochondrial; Plays a role in controlling neuronal activity and seizure susceptibility; Belongs to the citrate synthase family. (522 aa)
SpatSerine pyruvate aminotransferase (Spat) encodes an alanine-glyoxylate transaminase involved in glyoxylate catabolism. (394 aa)
GipPutative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family. (264 aa)
CG11291Phosphoprotein phosphatase activity; phosphatase activity. It is involved in the biological process described with: protein dephosphorylation; dephosphorylation; Belongs to the HAD-like hydrolase superfamily. (308 aa)
CG9149Uncharacterized protein; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
CG32487Uncharacterized protein; Phosphatase activity. It is involved in the biological process described with: dephosphorylation; Belongs to the HAD-like hydrolase superfamily. (320 aa)
CatCatalase (Cat) encodes an enzyme that catalyzes the decomposition of hydrogen peroxide. It reduces the amount of oxidative damage to biomolecules and protects cells from the toxic effects of reactive oxygen species. (506 aa)
CG7430Flavin adenine dinucleotide binding; dihydrolipoyl dehydrogenase activity; electron transfer activity. It is involved in the biological process described with: tricarboxylic acid cycle; lipoamide metabolic process; oxidation-reduction process; glycine catabolic process; cell redox homeostasis. (504 aa)
CG5567FI11325p; Phosphatase activity; phosphoprotein phosphatase activity; alkaline phosphatase activity. It is involved in the biological process described with: protein dephosphorylation; dephosphorylation. (330 aa)
CG10749L-malate dehydrogenase activity. It is involved in the biological process described with: carbohydrate metabolic process; malate metabolic process; tricarboxylic acid cycle. (347 aa)
CG10748L-malate dehydrogenase activity. It is involved in the biological process described with: tricarboxylic acid cycle; malate metabolic process; carbohydrate metabolic process. (349 aa)
Gs1Glutamine synthetase 1 (Gs1) encodes the mitochondrial enzyme that uses glutamate and ammonia as substrates to synthesize glutamine, which is a precursor of purine and pyrimidine synthesis. An adequate level of maternally supplied Gs1 product activity is necessary in the early embryonic development. High level of glutamine in mitochondria causes megamitochondrial formation in cells. (399 aa)
pplGlycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity); Belongs to the GcvH family. (165 aa)
AcCoASAcetyl-coenzyme A synthetase; Activates acetate so that it can be used for lipid synthesis or for energy generation; Belongs to the ATP-dependent AMP-binding enzyme family. (670 aa)
CG1236Uncharacterized protein; Glycerate dehydrogenase activity; glyoxylate reductase (NADP) activity; NAD binding; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; hydroxypyruvate reductase activity. It is involved in the biological process described with: oxidation-reduction process; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (347 aa)
CG6415Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (405 aa)
CG3999Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (985 aa)
Irp-1BIron regulatory protein 1B (Irp-1B) encodes a cytosolic aconitase highly homologous to the product of Irp-1A; Belongs to the aconitase/IPM isomerase family. (899 aa)
mAcon2Aconitate hydratase, mitochondrial; 4 iron, 4 sulfur cluster binding; aconitate hydratase activity. It is involved in the biological process described with: tricarboxylic acid cycle; multicellular organism reproduction; Belongs to the aconitase/IPM isomerase family. (783 aa)
CG14740Citrate (Si)-synthase activity. It is involved in the biological process described with: carbohydrate metabolic process; tricarboxylic acid cycle. (478 aa)
Mdh2Malate dehydrogenase 2 (Mdh2) encodes one of the enzymes in the tricarboxylic acid cycle in mitochondria; Belongs to the LDH/MDH superfamily. (336 aa)
Irp-1AIron regulatory protein 1A (Irp-1A) encodes a cytosolic aconitase that under iron deficiency (or if cytosolic superoxide is present) loses its iron-sulfur cluster, changes confirmation and binds iron regulatory elements (so far identified on the products of SdhB and Fer1HCH mRNAs); Belongs to the aconitase/IPM isomerase family. (902 aa)
CG18003L-lactate dehydrogenase activity; FMN binding; (S)-2-hydroxy-acid oxidase activity. It is involved in the biological process described with: lactate oxidation. (366 aa)
CG9886Glycerate kinase activity. It is involved in the biological process described with: protein phosphorylation; Belongs to the glycerate kinase type-2 family. (487 aa)
CG9314CG9314 protein; Catalase activity; heme binding. It is involved in the biological process described with: response to oxidative stress; hydrogen peroxide catabolic process; response to hydrogen peroxide; oxidation-reduction process. (506 aa)
KFaseKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Required for elimination of toxic metabolites. (300 aa)
Gs2Glutamine synthetase 2 (Gs2) encodes an enzyme that converts glutamate to glutamine. It is expressed in the embryonic nervous system and regulates the size of glutamate neurotransmitter pools and synapse assembly. (373 aa)
Mdh1Malate dehydrogenase 1 (Mdh1) encodes a L-malate dehydrogenase involved in the interconversion of malate and oxaloacetate. (337 aa)
CG10932LD24105p; acetyl-CoA C-acetyltransferase activity; acetyl-CoA C-acyltransferase activity. It is involved in the biological process described with: fatty acid beta-oxidation; fatty acid biosynthetic process; pyruvate metabolic process; Belongs to the thiolase-like superfamily. Thiolase family. (410 aa)
CG32488GH05933p; Phosphatase activity. It is involved in the biological process described with: dephosphorylation; Belongs to the HAD-like hydrolase superfamily. (307 aa)
mAcon1Aconitate hydratase, mitochondrial; Mitochondrial aconitase 1 (mAcon1) encodes an enzyme that harbors an iron-sulfur cluster and catalyses the first step of the Krebs Cycle in mitochondria, converting citrate into isocitrate; Belongs to the aconitase/IPM isomerase family. (787 aa)
CG5577GH10306p; Phosphatase activity. It is involved in the biological process described with: dephosphorylation; Belongs to the HAD-like hydrolase superfamily. (315 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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