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alpha-PheRS alpha-PheRS LysRS LysRS TyrRS-m TyrRS-m ProRS-m ProRS-m LeuRS-m LeuRS-m ArgRS ArgRS TrpRS-m TrpRS-m TyrRS TyrRS GluRS-m GluRS-m GlyRS GlyRS AlaRS-m AlaRS-m SerRS SerRS IleRS IleRS TrpRS TrpRS GatA GatA GluProRS GluProRS Slimp Slimp GatB GatB beta-PheRS beta-PheRS GlnRS GlnRS CG1750 CG1750 MetRS MetRS AsnRS-m AsnRS-m CysRS CysRS PheRS-m PheRS-m GatC GatC AlaRS AlaRS Pstk Pstk SecS SecS IleRS-m IleRS-m AspRS-m AspRS-m AsnRS AsnRS AspRS AspRS ValRS ValRS HisRS HisRS ArgRS-m ArgRS-m SerRS-m SerRS-m CysRS-m CysRS-m LeuRS LeuRS ThrRS ThrRS ValRS-m ValRS-m MetRS-m MetRS-m
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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alpha-PheRSPhenylalanyl-tRNA synthetase, alpha-subunit (alpha-PheRS) encodes a cytoplasmic aminoacyl-tRNA synthetase that catalyzes the ligation of Phenylalanine to its cognate tRNAPhe. Together with the beta-subunit it forms a tetrameric enzyme complex. This subunit provides the catalytic core. (498 aa)
LysRSLysine--tRNA ligase; tRNA binding; ATP binding; lysine-tRNA ligase activity. It is involved in the biological process described with: lysyl-tRNA aminoacylation. (607 aa)
TyrRS-mTyrosine--tRNA ligase, mitochondrial; Tyrosyl-tRNA synthetase, mitochondrial (TyrRS-m) encodes an enzyme that catalyzes the ligation of tyrosine to the mitochondrial-encoded tRNA-Tyr. The TyrRS-m protein is encoded by a nuclear gene and imported to the mitochondria where it functions in mitochondrial protein synthesis; Belongs to the class-I aminoacyl-tRNA synthetase family. (464 aa)
ProRS-mProlyl-tRNA synthetase, mitochondrial, isoform A; proline-tRNA ligase activity; ATP binding; glycine-tRNA ligase activity. It is involved in the biological process described with: glycyl-tRNA aminoacylation; prolyl-tRNA aminoacylation. (458 aa)
LeuRS-mLeucyl-tRNA synthetase, mitochondrial; aminoacyl-tRNA editing activity; leucine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: leucyl-tRNA aminoacylation; mitochondrial translation; Belongs to the class-I aminoacyl-tRNA synthetase family. (869 aa)
ArgRSProbable arginine--tRNA ligase, cytoplasmic; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. (665 aa)
TrpRS-mTryptophanyl-tRNA synthetase, mitochondrial (TrpRS-m) encodes a protein predicted to function within mitochondria to catalyze the ligation of tryptophan to its cognate tRNA to form tryptophanyl-tRNA. (665 aa)
TyrRStRNA binding; tyrosine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: tyrosyl-tRNA aminoacylation. (525 aa)
GluRS-mGlutamyl-tRNA synthetase, mitochondrial; glutamate-tRNA ligase activity; tRNA binding; ATP binding; zinc ion binding. It is involved in the biological process described with: glutamyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (511 aa)
GlyRSGlycyl-tRNA synthetase, isoform B; Glycyl-tRNA synthetase (GlyRS) encodes a protein involved in dendrite morphogenesis and larval lymph gland hemopoiesis. (765 aa)
AlaRS-mAlanine--tRNA ligase, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (1012 aa)
SerRSSeryl-tRNA synthetase (SerRS) encodes a protein that aminoacylates transfer RNAs (tRNA) for their use by the ribosome during protein synthesis. (501 aa)
IleRSIsoleucyl-tRNA synthetase, isoform A; isoleucine-tRNA ligase activity; tRNA binding; aminoacyl-tRNA editing activity; ATP binding. It is involved in the biological process described with: isoleucyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (1229 aa)
TrpRSTryptophanyl-tRNA synthetase (TrpRS) is expressed to high levels in the salivary gland. This could be incidental due to proximity to the salivary gland transcription factor encoded by sage; Belongs to the class-I aminoacyl-tRNA synthetase family. (430 aa)
GatAGlutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the amidase family. GatA subfamily. (508 aa)
GluProRSBifunctional glutamate/proline--tRNA ligase; Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family. (1714 aa)
SlimpSerine--tRNA synthetase-like protein Slimp; Essential protein which may play a role in mitochondrial morphogenesis and function. Has transfer RNA (tRNA)-binding activity and can bind tRNA(Ser) but does not have serine--tRNA ligase activity and does not bind ATP. (464 aa)
GatBGlutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). (516 aa)
beta-PheRSPhenylalanyl-tRNA synthetase, beta-subunit (beta-PheRS) encodes a cytoplasmic aminoacyl-tRNA synthetase that catalyzes the ligation of Phenylalanine to its cognate tRNAPhe. Together with the alpha-subunit it forms a tetrameric enzyme complex. This subunit plays a role in recognition and binding of tRNAPhe and it provides the editing site that hydrolyzes wrongfully activated or ligated compounds. (589 aa)
GlnRSProbable glutamine--tRNA ligase; glutamine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: dendrite morphogenesis; glutaminyl-tRNA aminoacylation. (778 aa)
CG1750Uncharacterized protein; methionyl-tRNA formyltransferase activity. It is involved in the biological process described with: conversion of methionyl-tRNA to N-formyl-methionyl-tRNA; biosynthetic process. (342 aa)
MetRSMethionyl-tRNA synthetase (MetRS) encodes an enzyme that catalyzes the covalent attachment of methionine to methionyl-tRNA, an essential first step of protein translation; Belongs to the class-I aminoacyl-tRNA synthetase family. (1022 aa)
AsnRS-mAsparaginyl-tRNA synthetase, mitochondrial; ATP binding; nucleic acid binding; asparagine-tRNA ligase activity. It is involved in the biological process described with: asparaginyl-tRNA aminoacylation. (460 aa)
CysRSCysteine--tRNA ligase, cytoplasmic; ATP binding; cysteine-tRNA ligase activity; tRNA binding. It is involved in the biological process described with: cysteinyl-tRNA aminoacylation. (741 aa)
PheRS-mProbable phenylalanine--tRNA ligase, mitochondrial; Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. (453 aa)
GatCGlutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). (148 aa)
AlaRSAlanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (966 aa)
PstkSD05444p2; tRNA binding. (292 aa)
SecSO-phosphoseryl-tRNA(Sec) selenium transferase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. (478 aa)
IleRS-mIsoleucyl-tRNA synthetase, mitochondrial; tRNA binding; aminoacyl-tRNA editing activity; ATP binding; isoleucine-tRNA ligase activity. It is involved in the biological process described with: isoleucyl-tRNA aminoacylation; mitochondrial translation; Belongs to the class-I aminoacyl-tRNA synthetase family. (941 aa)
AspRS-mAspartyl-tRNA synthetase, mitochondrial (AspRS-m) encodes a protein predicted to function within mitochondria to catalyze the ligation of aspartate to its cognate tRNA to form aspartyl-tRNA. (1082 aa)
AsnRSAsparaginyl-tRNA synthetase, isoform A; Nucleic acid binding; asparagine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: asparaginyl-tRNA aminoacylation. (558 aa)
AspRSAspartyl-tRNA synthetase (AspRS) is an essential gene that is predicted to encode an aspartate-tRNA ligase. It functions as a Sxl dosage-sensitive maternal modifier. (531 aa)
ValRSValyl-tRNA synthetase, isoform C; aminoacyl-tRNA editing activity; ATP binding; valine-tRNA ligase activity. It is involved in the biological process described with: tRNA aminoacylation for protein translation; valyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (1055 aa)
HisRSHistidyl-tRNA synthetase, isoform D; histidine-tRNA ligase activity; ATP binding. It is involved in the biological process described with: histidyl-tRNA aminoacylation; mitochondrial translation. (564 aa)
ArgRS-mArginyl-tRNA synthetase, mitochondrial, isoform A; ATP binding; arginine-tRNA ligase activity. It is involved in the biological process described with: arginyl-tRNA aminoacylation; mitochondrial translation; Belongs to the class-I aminoacyl-tRNA synthetase family. (594 aa)
SerRS-mSeryl-tRNA synthetase, mitochondrial (SerRS-m) encodes an enzyme that catalyses the aminoacylation of tRNAser with serine, to be used for gene translation during protein synthesis. (417 aa)
CysRS-mCysteinyl-tRNA synthetase, mitochondrial, isoform A; ATP binding; cysteine-tRNA ligase activity. It is involved in the biological process described with: cysteinyl-tRNA aminoacylation. (558 aa)
LeuRSLeucyl-tRNA synthetase, isoform A; leucine-tRNA ligase activity; ATP binding; aminoacyl-tRNA editing activity. It is involved in the biological process described with: leucyl-tRNA aminoacylation; wound healing; Belongs to the class-I aminoacyl-tRNA synthetase family. (1182 aa)
ThrRSThreonyl-tRNA synthetase, isoform A; threonine-tRNA ligase activity; aminoacyl-tRNA ligase activity; ATP binding. It is involved in the biological process described with: tRNA aminoacylation for protein translation; threonyl-tRNA aminoacylation. (747 aa)
ValRS-mValyl-tRNA synthetase, mitochondrial, isoform A; valine-tRNA ligase activity; aminoacyl-tRNA editing activity; ATP binding. It is involved in the biological process described with: tRNA aminoacylation for protein translation; valyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (994 aa)
MetRS-mMethionine--tRNA ligase, mitochondrial; ATP binding; methionine-tRNA ligase activity. It is involved in the biological process described with: methionyl-tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (582 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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