STRINGSTRING
kdn kdn CG3483 CG3483 CG1640 CG1640 CG1673 CG1673 CG32026 CG32026 Got2 Got2 Irp-1B Irp-1B CG6465 CG6465 mAcon2 mAcon2 CG14740 CG14740 Idh3b Idh3b Irp-1A Irp-1A CG6733 CG6733 CG6738 CG6738 Got1 Got1 CG5028 CG5028 Idh Idh Idh3a Idh3a CG17109 CG17109 CG6726 CG6726 CG17110 CG17110 mAcon1 mAcon1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
kdnProbable citrate synthase, mitochondrial; Plays a role in controlling neuronal activity and seizure susceptibility; Belongs to the citrate synthase family. (522 aa)
CG3483CG3483 protein; Isocitrate dehydrogenase (NAD+) activity. It is involved in the biological process described with: isocitrate metabolic process; tricarboxylic acid cycle. (391 aa)
CG1640AT04676p; Pyridoxal phosphate binding; L-alanine:2-oxoglutarate aminotransferase activity. It is involved in the biological process described with: biosynthetic process. (575 aa)
CG1673Branched-chain-amino-acid transaminase activity. It is involved in the biological process described with: valine biosynthetic process; branched-chain amino acid biosynthetic process; leucine biosynthetic process; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (443 aa)
CG32026GH12815p; Magnesium ion binding; NAD binding; isocitrate dehydrogenase (NAD+) activity. It is involved in the biological process described with: tricarboxylic acid cycle; isocitrate metabolic process. (719 aa)
Got2Aspartate aminotransferase; Glutamate oxaloacetate transaminase 2 (Got2) encodes an L-aspartate:2-oxoglutarate aminotransferase involved in glutamate biosynthesis, which in turn regulates postsynaptic receptor field size. (431 aa)
Irp-1BIron regulatory protein 1B (Irp-1B) encodes a cytosolic aconitase highly homologous to the product of Irp-1A; Belongs to the aconitase/IPM isomerase family. (899 aa)
CG6465GH04054p; Metallopeptidase activity; aminoacylase activity. It is involved in the biological process described with: proteolysis; cellular amino acid metabolic process. (401 aa)
mAcon2Aconitate hydratase, mitochondrial; 4 iron, 4 sulfur cluster binding; aconitate hydratase activity. It is involved in the biological process described with: tricarboxylic acid cycle; multicellular organism reproduction; Belongs to the aconitase/IPM isomerase family. (783 aa)
CG14740Citrate (Si)-synthase activity. It is involved in the biological process described with: carbohydrate metabolic process; tricarboxylic acid cycle. (478 aa)
Idh3bIsocitrate dehydrogenase 3b (Idh3b) encodes a mitochondrial enzyme of the tricarboxylic acid cycle involved in salivary gland cell autophagy. (370 aa)
Irp-1AIron regulatory protein 1A (Irp-1A) encodes a cytosolic aconitase that under iron deficiency (or if cytosolic superoxide is present) loses its iron-sulfur cluster, changes confirmation and binds iron regulatory elements (so far identified on the products of SdhB and Fer1HCH mRNAs); Belongs to the aconitase/IPM isomerase family. (902 aa)
CG6733RE20374p; Aminoacylase activity. It is involved in the biological process described with: cellular amino acid metabolic process. (401 aa)
CG6738FI02833p; Aminoacylase activity. It is involved in the biological process described with: cellular amino acid metabolic process. (401 aa)
Got1Glutamate oxaloacetate transaminase 1 (Got1) encodes an L-aspartate:2-oxoglutarate aminotransferase involved in glutamate biosynthesis. (437 aa)
CG5028RH49423p; Isocitrate dehydrogenase (NAD+) activity. It is involved in the biological process described with: tricarboxylic acid cycle; isocitrate metabolic process. (402 aa)
IdhIsocitrate dehydrogenase (Idh) encodes a cytosolic enzyme that catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate, with the concomitant reduction of NADP[+] to NADPH. It functions, along with Men, Zw, and Pgd, in a small network of NADP reducing enzymes. (479 aa)
Idh3aProbable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Magnesium ion binding; isocitrate dehydrogenase (NAD+) activity; NAD binding. It is involved in the biological process described with: tricarboxylic acid cycle; isocitrate metabolic process. (377 aa)
CG17109Uncharacterized protein, isoform A; Aminoacylase activity. It is involved in the biological process described with: cellular amino acid metabolic process. (400 aa)
CG6726Uncharacterized protein, isoform A; Aminoacylase activity. It is involved in the biological process described with: cellular amino acid metabolic process. (401 aa)
CG17110AT09807p; Aminoacylase activity. It is involved in the biological process described with: cellular amino acid metabolic process. (402 aa)
mAcon1Aconitate hydratase, mitochondrial; Mitochondrial aconitase 1 (mAcon1) encodes an enzyme that harbors an iron-sulfur cluster and catalyses the first step of the Krebs Cycle in mitochondria, converting citrate into isocitrate; Belongs to the aconitase/IPM isomerase family. (787 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.