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| | eIF4E7 | Eukaryotic translation initiation factor 4E7 (eIF4E7) encodes a protein involved in translational initiation. (429 aa) |
| | Nmd3 | 60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (521 aa) |
| | eIF3g1 | Eukaryotic translation initiation factor 3 subunit G-1; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. (269 aa) |
| | eIF2Bbeta | Eukaryotic translation initiation factor 2B subunit beta; Translation initiation factor activity; guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: cellular response to hypoxia; regulation of translational initiation; translational initiation; Belongs to the eIF-2B alpha/beta/delta subunits family. (352 aa) |
| | Cbp80 | Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp80 does not bind directly capped RNAs [...] (800 aa) |
| | Pop1 | Lethal (1) G0045; Ribonuclease P activity; ribonuclease MRP activity. It is involved in the biological process described with: tRNA processing; rRNA processing; tRNA 5'-leader removal; RNA phosphodiester bond hydrolysis, endonucleolytic. (857 aa) |
| | Upf2 | RE04053p; Upf2 (Upf2) encodes a protein required for nonsense-mediated mRNA decay (NMD). It interacts directly with the product of Upf1 to identify and degrade NMD-substrate mRNAs, including mRNAs containing premature termination codons and a number of normal endogenous mRNAs. (1241 aa) |
| | mago | Protein mago nashi; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Involved in exon definition of genes containing long introns, including the rolled/MAPK gene. The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm. Has a role in oskar mRNA localization to the posterior pole of the developing oocyte, and may also be involved in polarization of the oocyte microtubule cytoskeleton. (147 aa) |
| | Rae1 | Rae1 (Rae1) encodes a nucleoporin member of the WD40-repeat beta propeller protein super family. Biological roles of the pleiotropic Rae1 gene product include poly(A)+ mRNA export, cell cycle regulation, male meiosis control and male germ cell post-meiotic differentiation. (346 aa) |
| | Nup214 | Nuclear pore complex protein Nup214; Serves as a docking site in the receptor-mediated import of substrates across the nuclear pore complex including emb, RanGAP and phosphorylated Mad. Protects mbo/Nup88 from proteasomal degradation at the nuclear pore. Together with mbo/Nup88, sequesters emb in the cytoplasm and thereby attenuates nuclear export signal (NES)-mediated nuclear export. Together with mbo/Nup88, required for the nuclear import of the Rel family transcription factors dorsal (dl) and Dorsal-related immunity factor (Dif) and the activation of an immune response. (1711 aa) |
| | eIF2Bdelta | Eukaryotic translation initiation factor 2B subunit delta, isoform A; Translation initiation factor activity. It is involved in the biological process described with: translational initiation; Belongs to the eIF-2B alpha/beta/delta subunits family. (626 aa) |
| | CG12782 | WD_REPEATS_REGION domain-containing protein; Ubiquitin binding; RNA binding. It is involved in the biological process described with: RNA export from nucleus; transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery; mRNA export from nucleus. (336 aa) |
| | thoc5 | THO complex subunit 5; The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress. Belongs to the THOC5 family. (616 aa) |
| | Upf3 | Upf3, isoform B; Upf3 (Upf3) encodes a protein that regulates targets of the nonsense-mediated mRNA decay pathway. This pathway participates in homeostatic gene expression regulation and plays a quality control role in the elimination of mRNAs with premature termination codons. The product of Upf3 is involved in cell cycle progression and general developmental rate. (492 aa) |
| | Pym | Partner of Y14 and mago; Regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor by disrupting mature EJC from spliced mRNAs. Required for normal localization of osk mRNA to the posterior pole of the developing oocyte. Does not interact with the small ribosomal unit [...] (207 aa) |
| | Nxt1 | NTF2-related export protein; Stimulator of protein export for NES-containing proteins (By similarity). Plays a role in the nuclear export of mRNA. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity). In the ovaries, forms a complex with nxf2, Panx and piwi which acts as effectors of cotranscriptional transposon silencing. (133 aa) |
| | thoc7 | THO complex protein 7; The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress. Belongs to the THOC7 family. (288 aa) |
| | eIF1 | Eukaryotic translation initiation factor eIF1; Probably involved in translation. (110 aa) |
| | sbr | Nuclear RNA export factor 1; Mediates the export of the majority of mRNAs from the nucleus to the cytoplasm. (672 aa) |
| | Ran | GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] (216 aa) |
| | Upf1 | Regulator of nonsense transcripts 1 homolog; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an Upf1-Upf2-Upf3 surveillance complex is believed to activate NMD (By similarity). (1180 aa) |
| | Nup93-1 | Nuclear pore complex protein Nup93-1; Required for nuclear pore complex assembly, maintenance and function. Required for nuclear import of phosphorylated Mad via importin msk. Has no role in classical nuclear localization signal (cNLS)-dependent nuclear import via importin-beta. Together with Nup62 and Nup154, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells ; Belongs to the nucleoporin interacting component (NIC) family. (823 aa) |
| | caz | Cabeza (caz) encodes a chromatin binding protein involved in locomotion, synaptic growth at the neuromuscular junction and eye development. (399 aa) |
| | Nup35 | Nucleoporin Nup35; Functions as a component of the nuclear pore complex (NPC) (By similarity). May have a role in the organization of the inner nuclear membrane proteins at the nuclear envelope together with Nup154. (331 aa) |
| | Nup205 | Nuclear pore complex protein Nup205; Plays a role in the nuclear pore complex (NPC) assembly and maintenance, but with limited role in NPC permeability. Required for specific nuclear import pathways such as Mad import. Belongs to the NUP186/NUP192/NUP205 family. (2090 aa) |
| | Gem2 | Protein Gemin2; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm, is required for pre-mRNA splicing in the nucleus and acts as a chaperone that discriminates target and non- target RNAs of Sm proteins. (245 aa) |
| | Pop5 | Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. (145 aa) |
| | eIF3e | Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In addition to its role in the eIF-3 complex, also functions in protein ubiquitination and degradation. During mitosis required for regulating mitotic mic [...] (435 aa) |
| | Ran-like | GTP-binding nuclear protein Ran-like; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. (217 aa) |
| | Srrm1 | FI04407p; SRm160 (SRm160) encodes a conserved RNA-binding protein that participates in the exon junction complex and is involved in pre-mRNA splicing and 3' end formation. It participates in somatic sex determination, cell death, retinal development and the control of circadian rhythm. Direct targets include rl. (954 aa) |
| | eIF2beta | Eukaryotic translation initiation factor 2 subunit 2; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This preinitiation complex mediates ribosomal recognition of a start codon during the scanning process of the leader region; Belongs to the eIF-2-beta/eIF-5 family. (312 aa) |
| | eIF4E3 | Eukaryotic translation initiation factor 4E3 (eIF4E3) encodes a protein that binds the 7-methyl-guanosine cap structure of mRNA. It is a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. eIF4E3 is primarily expressed in testes and is required for male fertility, but not for viability. (244 aa) |
| | eIF4E5 | Eukaryotic translation initiation factor 4E5 (eIF4E5) encodes a protein in translational initiation. (232 aa) |
| | Pop4 | Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (206 aa) |
| | eIF4E4 | Eukaryotic translation initiation factor 4E4 (eIF4E4) encodes a protein involved in translational initiation. (229 aa) |
| | Thor | 4E-binding protein THOR; Thor (Thor) encodes a eukaryotic translation initiation factor 4E binding protein that is controlled by the product of tor. It contributes to translation regulation, response to environmental stress and cell growth regulation. (117 aa) |
| | Hpr1 | Hpr1 protein; It is involved in the biological process described with: mRNA export from nucleus in response to heat stress; mRNA export from nucleus; regulation of DNA-templated transcription, elongation; signal transduction. (701 aa) |
| | eIF3f1 | Eukaryotic translation initiation factor 3 subunit F-1; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (280 aa) |
| | eIF3h | Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (338 aa) |
| | eIF3i | Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (326 aa) |
| | Hel25E | ATP-dependent RNA helicase WM6; Required for mRNA export out of the nucleus. Probable RNA helicase that may regulate entry into mitosis by down-regulating the expression of other genes whose activity may be rate-limiting for entry into mitosis during embryogenesis. Binds to salivary gland chromosomes and modifies position effect variegation. Promotes an open chromatin structure that favors transcription during development by regulating the spread of heterochromatin. (424 aa) |
| | smt3 | Small ubiquitin-related modifier; Smt3 (smt3) encodes the only Drosophila SUMO family protein. It is required for embryonic patterning and mitosis. It may also have roles in wing patterning, Dpp signaling, and Ras/MAPK signaling. It localizes to the nucleus during interphase and to the kinetochores and midbodies during mitosis; Belongs to the ubiquitin family. SUMO subfamily. (90 aa) |
| | emb | Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Binds cooperatively to the NES on its target protein and to the small GTPase Ran in its active GTP-bound form. Involved in the export of dl, RpS2 and the pre-40S ribosome from the nucleus to the cytoplasm. Plays an important role in nuclear pore assembly by mediating nucleoporin condensation and biogenesis of annulate lamellae. Required for the function or maintenance of certain tissues such as brain and gut. (1063 aa) |
| | Nup107 | Nuclear pore complex protein Nup107; Plays a role in nuclear pore complex (NPC) assembly and maintenance. Required for nuclear import of Mad. Plays a role in double strand break repair by relocalizing the heterochromatic double strain breaks (DSBs) to the nuclear periphery as part of the homologous recombination (HR) repair process. Regulates cytokinesis during spermatocyte meiosis by maintaining type-B lamin Lam localization to the spindle envelope. Regulates female gonad development and oogenesis. Belongs to the nucleoporin Nup84/Nup107 family. (845 aa) |
| | Nup160 | Nuclear pore complex protein Nup160 homolog; Functions as a component of the nuclear pore complex (NPC). Involved in poly(A)+ RNA transport (By similarity). Required for nuclear import of Mad. May play a role in double strand break DNA repair. Essential for nephrocyte development. (1411 aa) |
| | CG18789 | C3H1-type domain-containing protein; Metal ion binding. (398 aa) |
| | RanGAP | Ran GTPase-activating protein; GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state (By similarity). Trans-acting factor necessary for meiotic distortion. Distortion is only seen in individuals that carry the RanGAP tandem duplication and express a RanGAP truncated protein. Binding of truncated RanGAP product to the Responder(RSP) locus initiates events that lead to sperm dysfunction. During oogenesis, plays a role in the biogenesis of annulate lamellae containing nuclear pore complex components. Belongs to the RN [...] (596 aa) |
| | nxf4 | Nuclear export factor 4; RNA binding. It is involved in the biological process described with: poly(A)+ mRNA export from nucleus. (301 aa) |
| | Ref1 | RNA and export factor binding protein 1; mRNA binding; nucleic acid binding. It is involved in the biological process described with: mRNA splicing, via spliceosome. (266 aa) |
| | CG7483 | Eukaryotic initiation factor 4A-III; ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Involved in exon definition of genes containing long introns, including the rolled/MAPK gene. Has a role in oskar mRNA localization at the posterior pole of the developing oocyte. (399 aa) |
| | tex | Tex protein; It is involved in the biological process described with: mRNA export from nucleus. (320 aa) |
| | RnpS1 | RNA-binding protein S1 (RnpS1) encodes a protein involved in RNA splicing and regulation of DNA transposition. (374 aa) |
| | CG14712 | LD43047p; Structural constituent of nuclear pore; nuclear localization sequence binding. It is involved in the biological process described with: protein import into nucleus; RNA export from nucleus. (1266 aa) |
| | eIF3d2 | Eukaryotic translation initiation factor 3 subunit D-2; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7- methylguanosine cap of a subset of mRNAs. (551 aa) |
| | mbo | Nuclear pore complex protein Nup88; Essential component of nuclear pore complex. Required for the anchoring of Nup214 and emb on the nuclear envelope and thereby attenuates nuclear export signal (NES)-mediated nuclear export. Together with Nup214, required for the nuclear import of the Rel family transcription factors dorsal (dl) and Dorsal-related immunity factor (Dif) and the activation of an immune response. (702 aa) |
| | Nup93-2 | Structural constituent of nuclear pore. It is involved in the biological process described with: poly(A)+ mRNA export from nucleus; protein import into nucleus; nuclear pore organization. (796 aa) |
| | Cyfip | Cytoplasmic FMR1-interacting protein; Specifically Rac1-associated protein 1 (Sra-1) encodes an essential protein that is a component of the WAVE actin nucleator complex. It controls actin cytoskeleton remodeling and interacts with the products of Fmr1 and Rac1. It controls morphogenesis and synapse organization. (1291 aa) |
| | Cbp20 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp20 recognizes and binds capped RNAs [...] (154 aa) |
| | Nup43 | Nucleoporin 43kD; It is involved in the biological process described with: mitotic cell cycle. (358 aa) |
| | Nup58 | Nuclear pore complex protein Nup58; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. (546 aa) |
| | eIF3g2 | Eukaryotic translation initiation factor 3 subunit G-2; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. (273 aa) |
| | Nup133 | Nuclear pore complex protein Nup133; Probable component of the nuclear pore complex (NPC) (Probable). Plays a role in NPC assembly and/or maintenance. (1200 aa) |
| | Nup98-96 | Nuclear pore complex protein Nup98-Nup96; Part of the nuclear pore complex (NPC). Required for MAD import as part of the Nup107-160 complex and required for nuclear export of Moe probably via its association with Rae1. Plays a role in nuclear mRNA export. Promotes cell antiviral response by upregulating FoxK-dependent antiviral gene transcription. In germline stem cells, involved in their maintenance and division together with the TGF-Beta and EGFR signaling pathways. In larval lymph glands, has a role in the maintenance of hematopoiesis by regulating Pvr expression. [Nuclear pore comp [...] (1960 aa) |
| | Ndc1 | Nucleoporin Ndc1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope; Belongs to the NDC1 family. (578 aa) |
| | eIF2Balpha | Eukaryotic translation initiation factor 2B subunit alpha (eIF2Balpha) encodes a regulatory subunit of the eIF2B heteropentamer; Belongs to the eIF-2B alpha/beta/delta subunits family. (306 aa) |
| | Rpp14b | GEO10372p1; Ribonuclease P activity. It is involved in the biological process described with: tRNA 5'-leader removal. (112 aa) |
| | eEF1alpha2 | Elongation factor 1-alpha 2; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (462 aa) |
| | eIF3f2 | Eukaryotic translation initiation factor 3 subunit F-2; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (286 aa) |
| | Rpp25 | FI09323p; RNA binding; ribonuclease P activity. It is involved in the biological process described with: tRNA 5'-leader removal. (206 aa) |
| | pAbp | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Since it interacts with the cap-associating translation initiation factor eIF4G, it is likely that it functions by linking Atx2 to the cap-binding complex. Forms a complex with tyf and Atx2 which functions in adult circadian pacemaker neurons to sustain circadian rhythms likely by switching between activator and repressor modes of post-transcriptional regulation via interaction with Lsm12a or me31B, respectively. The activator complex (Atx2-tyf activator complex) activates the TYF-dependent translation of per to maintain 24 [...] (634 aa) |
| | Nup75 | Nuclear pore complex protein Nup75; Component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance (By similarity). Required for nuclear import of phosphorylated Mad via importin msk. Has no role in classical nuclear localization signal (cNLS)-dependent nuclear import via importin-beta. Facilitates the interaction between Nup93 and sec13 with msk. (668 aa) |
| | icln | Methylosome subunit pICln; Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm comple [...] (215 aa) |
| | eIF3b | Eukaryotic translation initiation factor 3 subunit B; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (690 aa) |
| | CG8963 | SD01637p; RNA binding; translation activator activity. It is involved in the biological process described with: regulation of translational initiation. (559 aa) |
| | Nup62 | Nuclear pore glycoprotein p62; Essential component of the nuclear pore complex (By similarity). The N-terminal is probably involved in nucleocytoplasmic transport (By similarity). The C-terminal is involved in protein- protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of Nup62 to the pore complex (By similarity). Binds to transcriptionally active genes. Negatively regulates chromatin attachment to the nuclear envelope, probably by preventing chromatin tethering by Nup154. (394 aa) |
| | eIF2Bgamma | Eukaryotic translation initiation factor 2B subunit gamma; Translation initiation factor activity; nucleotidyltransferase activity; guanyl-nucleotide exchange factor activity. It is involved in the biological process described with: translational initiation; cellular response to hypoxia; cytoplasmic translational initiation. (455 aa) |
| | Nup54 | Probable nucleoporin Nup54; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner. (610 aa) |
| | RNaseZ | Ribonuclease Z, mitochondrial; Ribonuclease Z (RNaseZ) is a highly conserved gene that encodes the endoribonuclease RNase Z, which cleaves pre-tRNA molecules directly 3' to the discriminator. It has at least two biological roles - nuclear pre-tRNA processing and mitochondrial primary transcript processing. (766 aa) |
| | eIF3j | Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (236 aa) |
| | CG10459 | Uncharacterized protein. (322 aa) |
| | tsu | RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. Involved in exon definition of genes containing long introns, including the rolled/MAPK gene. The mago-tsu heterodimer interacts with the EJC key regulator Pym leading to EJC disassembly in the cytoplasm. Has a role in oskar mRNA localization to the posterior pole of the developing oocyte. Belongs to the RBM8A family. (165 aa) |
| | Phax | Phosphorylated adaptor for RNA export, isoform A; RNA binding. It is involved in the biological process described with: snRNA export from nucleus. (453 aa) |
| | Gle1 | Nucleoporin Gle1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity). (677 aa) |
| | Nup50 | Nuclear pore complex protein Nup50; Component of the nuclear pore complex that has a direct role in nuclear protein import (By similarity). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta- cargo complex and importin recycling (By similarity). Binds to transcriptionally active chromatin sites when located in the nucleoplasm and is involved in transcriptional activation. (564 aa) |
| | Nup44A | Nucleoporin seh1; Probable component of the nuclear pore complex (NPC) (By similarity). Involved in maintaining the localization of another nucleoporin Mtor to the nuclear envelope of early meiotic female germline cells. It is not involved in recruiting the nucleoporins Mtor, Nup107, Nup153 and FG-containing nucleoporins to the NPC ; Belongs to the WD repeat SEC13 family. (354 aa) |
| | eIF3d1 | Eukaryotic translation initiation factor 3 subunit D-1; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7- methylguanosine cap of a subset of mRNAs. (560 aa) |
| | TBPH | TAR DNA-binding protein-43 homolog (TBPH) encodes an RNA-binding protein that belongs to the hnRNP family. It contributes to synaptic growth of motor neurons and glial wrapping. (531 aa) |
| | csul | Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA) (By similarity). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins SmD1 and SmD3. Required for arginine symmetrical dimethylation of piwi family proteins, piwi, aub and AGO3, during germline development. Required during oogenesis for pole cell formation in the pathway controlled by oskar (osk) and for abdominal segments during early embryogenesis. [...] (610 aa) |
| | eIF5 | Eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity). (464 aa) |
| | eIF2Bepsilon | Eukaryotic translation initiation factor 2B subunit epsilon (eIF2Bepsilon) encodes a guanyl-nucleotide exchange factor. (669 aa) |
| | Rpp14a | Uncharacterized protein; Ribonuclease P activity. It is involved in the biological process described with: tRNA 5'-leader removal. (111 aa) |
| | CG34334 | SD20656p; mRNA binding; nucleic acid binding. It is involved in the biological process described with: regulation of alternative mRNA splicing, via spliceosome; mRNA splicing, via spliceosome; RNA splicing. (708 aa) |
| | eIF4G1 | Eukaryotic translation initiation factor 4G1 (eIF4G1) encodes a protein that contributes to translation and spermatogenesis. (1919 aa) |
| | wmd | Wing morphogenesis defect (wmd) encodes an essential WD-repeat protein that is required for wing development and motor behavior. (328 aa) |
| | Pnn | Pinin, isoform B; It is involved in the biological process described with: mRNA splicing, via spliceosome; cell adhesion. (307 aa) |
| | CG7907 | IP13758p; mRNA binding; RNA cap binding. It is involved in the biological process described with: mRNA transport; mRNA splicing, via spliceosome; mRNA cis splicing, via spliceosome; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. (753 aa) |
| | eIF4B | Eukaryotic translation initiation factor 4B (eIF4B) encodes a protein involved in cap-dependent translation, cell survival, and proliferation. (459 aa) |
| | Snup | Snurportin-1; Snurportin (Snup) encodes a transport adaptor protein that functions together with the product of msk to carry out nuclear import of small nuclear RNPs. It binds specifically to the 2,2,7-trimethylguanosine cap structure that is present on mature snRNAs. Snup is an essential gene, and the protein shuttles between the cytoplasm and the nucleus. (351 aa) |
| | CG42304 | LD20870p; DNA binding; nucleosome binding. (565 aa) |
| | moi | Modigliani (moi) encodes a fast evolving, not evolutionary conserved, protein required for telomere maintenance. It is a member of terminin capping-complex that prevents telomere fusions. (178 aa) |
| | eIF4EHP | Eukaryotic translation initiation factor 4E homologous protein (eIF4EHP) encodes a protein that binds the 7-methyl-guanosine cap structure of mRNA and functions as a negative regulator of translation. The product of eIF4EHP contributes to embryonic patterning by negatively regulating translation of the products of cad and hb, and is also implicated in regulating ecdysone biosynthesis. (248 aa) |
| | CG2100 | GM13341p; ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity; tRNA binding. It is involved in the biological process described with: tRNA 3'-terminal CCA addition; mitochondrial tRNA 3'-end processing; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (477 aa) |
| | tho2 | Tho2, isoform B; Tho2 (tho2) encodes a component of the THO complex that plays an essential role in nuclear export of mRNAs. (1642 aa) |
| | CG13137 | Uncharacterized protein; It is involved in the biological process described with: nucleocytoplasmic transport. (440 aa) |
| | eIF4E6 | Eukaryotic translation initiation factor 4E6 (eIF4E6) encodes a RNA 7-methylguanosine cap binding protein. (173 aa) |
| | tacc | Transforming acidic coiled-coil protein (tacc) encodes a centrosomal protein that helps to stabilize microtubules. It seems to influence microtubules indirectly, primarily through its interaction with the product of msps. It is also phosphorylated by the product of aurA, and this activates its ability to stabilize microtubules. (1322 aa) |
| | Nup358 | E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase (By similarity). Component of the nuclear pore complex (NPC), a complex required for trafficking across the nuclear envelope. Required for nuclear import of nuclear localization signal (NLS)-containing proteins in an importin alpha/importin beta-dependent manner, but also for the nuclear import of specific proteins such as phosphorylated Mad or the sesquiterpenoid juvenile hormone receptor Met as part of the juvenile hormone signal transduction pathway. Plays a role in nuclear mRNA export by recruiting the mRNA transport complex com [...] (2718 aa) |
| | CG43069 | GEO02512p1. (79 aa) |
| | Fs(2)Ket | Importin subunit beta; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. In Drosophila, may not function as a snRNP import receptor as it does not interact with components of the snRNP complex such as snRNP U1, U2, U4/U6 and Snup. (884 aa) |
| | Nup188 | Nucleoporin 188kDa, isoform C; Structural constituent of nuclear pore. It is involved in the biological process described with: RNA export from nucleus; protein import into nucleus; nuclear pore organization. (1866 aa) |
| | eIF4A | Eukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Involved in germ cell formation. (403 aa) |
| | Fmr1 | Synaptic functional regulator FMR1; Polyribosome-associated RNA-binding protein that plays a role in neuronal development and synaptic plasticity through the regulation of protein synthesis of mRNAs. Plays a role as a negative translational regulator of specific mRNAs. Represses translation of the microtubule-associated protein futsch mRNA to regulate microtubule-dependent synaptic growth and function. May also be involved in microRNA (miRNA)-mediated translational suppression as part of the RNA-induced silencing complex (RISC). Required for stability of the central pair of microtubule [...] (729 aa) |
| | Ref2 | RNA and export factor binding protein 2, isoform A; mRNA binding; nucleic acid binding. (220 aa) |
| | eIF5B | Protein binding; translation initiation factor activity; GTPase activity; GTP binding; DEAD/H-box RNA helicase binding. It is involved in the biological process described with: translational initiation. (1144 aa) |
| | lwr | Lesswright (lwr) encodes Ubc9, a SUMO conjugating enzyme that accepts SUMO from the SUMO activating enzyme and hands it off to the SUMO conjugation target. It has documented biological functions in innate immunity, meiosis, and anterior patterning of the embryo. (159 aa) |
| | CG18787 | C3H1-type domain-containing protein; Nuclear localization sequence binding; RNA binding; metal ion binding; structural constituent of nuclear pore. It is involved in the biological process described with: protein import into nucleus; RNA export from nucleus; telomere tethering at nuclear periphery; posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery. (398 aa) |
| | Smn | Survival motor neuron protein; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm, is required for pre-mRNA splicing in the nucleus and acts as a chaperone that discriminates target and non- target RNAs of Sm proteins. Required for normal expression of spliceosomal snRNAs and for U12 intron splicing. Required in cholinergic neurons, but not in motor neurons, to ensure correct splicing and proper levels of stas mRNA and normal neurotransmitter release by motor neurons. However, Smn is required in motor neurons, but not in cholinergic neurons, for nor [...] (226 aa) |
| | btz | Barentsz, isoform D; Barentsz (btz) encodes a component of the exon junction complex that is recruited to spliced mRNAs to mark where introns have been removed. It is required for the posterior localization of osk mRNA. (806 aa) |
| | Dbp80 | DEAD-box helicase Dbp80; Dead box protein 80 (Dbp80) encodes a putative ATP-dependent RNA helicase (DEAD box helicase), based on sequence similarity to other Dead box proteins, which are involved in mRNA export from the nucleus. (481 aa) |
| | eEF1alpha1 | Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (463 aa) |
| | Nup37 | Nucleoporin Nup37; As part of the nuclear pore complex (NPC), has a role in its assembly and function. (320 aa) |
| | Mtor | Nucleoprotein TPR; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleoporin-associated regions (NARs) that define transcriptionally active regions of the genome. Associates with extended chromosomal regions that alternate between domains of high density binding with those of lo [...] (2346 aa) |
| | cocoon | AT09813p; RNA binding; mRNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding. It is involved in the biological process described with: regulation of RNA metabolic process. (318 aa) |
| | eIF4E1 | Eukaryotic translation initiation factor 4E1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition. Belongs to the eukaryotic initiation factor 4E family. (259 aa) |
| | Gem3 | Gemin3, isoform A; Gemin 3 (Gem3) encodes an RNA helicase and a member of the SMN-Gemins complex. It is a component of the cytoplasmic U snRNP body and nuclear gems. It is required in the motor system for viability, neuromuscular junction development and motor behaviour. (1028 aa) |
| | NAT1 | NAT1, isoform D; NAT1 (NAT1) encodes a protein involved in chaeta development. (1488 aa) |
| | Gp210 | Glycoprotein 210 kDa (Gp210) encodes a glycoprotein of the nuclear pore complex. (1876 aa) |
| | Acn | Acinus, isoform A; Acinus (Acn) encodes nuclear protein that, together with the products of a Bin1 and RnpS1, forms the ASAP complex that contributes to the regulation of alternative splicing. The Acn protein also functions in basal, starvation-independent autophagy. (739 aa) |
| | Rpp30 | RNaseP protein p30 (Rpp30) encodes a protein involved in tRNA processing. (297 aa) |
| | eIF2gamma | Eukaryotic translation initiation factor 2 subunit 3; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction cataly [...] (475 aa) |
| | Aladin | Aladin; Involved in mitotic spindle assembly. (466 aa) |
| | Nup153 | Nuclear pore complex protein Nup153; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC. Essential for the nuclear import of nuclear localization signal (NLS)-containing proteins in a Importin alpha/Importin beta receptor-dependent manner. Required for nuclear import of Mad. Plays a role in chromosomal organization and gene expression regulation; stimulates transcription by promoting the formation of an open chromatin environment. Binds chromatin to nucleopor [...] (1929 aa) |
| | Nup154 | Nuclear pore complex protein Nup154; Component of the nuclear pore complex. Has a role in the organization of the inner nuclear membrane proteins at the nuclear envelope. In germ cells, plays a role in the nuclear localization of components of the dpp signaling pathways, such as Medea and phosphorylated Mad. Binds to chromatin, and together with Nup62 and Nup93-1, contributes to karyosome morphology and chromatin organization including attachment to the nuclear envelope in oocytes and nurse cells. Has a role in female fertility including egg chamber development; in nurse cells, has a r [...] (1365 aa) |
| | eIF3c | Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (910 aa) |
| | Ranbp21 | Ranbp21, isoform A; RNA binding; nuclear export signal receptor activity; Ran GTPase binding. It is involved in the biological process described with: regulation of protein export from nucleus; RNA export from nucleus. (1241 aa) |
| | eIF2alpha | Eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha) encodes one of three subunits of the eIF-2 complex required for the initiation of translation. eIF2alpha is classified as a 'Minute' gene as heterozygous mutants exhibit a slower developmental rate and small adult bristles. (341 aa) |
| | Tgs1 | Trimethylguanosine synthase 1 (Tgs1) encodes an essential cytoplasmic enzyme that hypermethylates the 7-methylguanosine cap of snRNPs to a 2,2,7-trimethylguanosine cap. It is required in the motor system for viability and motor behaviour. (466 aa) |
| | eIF1A | Eukaryotic translation initiation factor 1A (eIF1A) encodes a protein required for mRNA translation. It is involved in 43S pre-initiation complex assembly, ensuring correct AUG start codon selection, and its dissociation from the 40S ribosome subunit is considered crucial for start codon recognition. (148 aa) |
| | Nxf3 | Nuclear export factor 3, isoform B. (559 aa) |
| | Rpp20 | Ribonuclease P protein subunit p20; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP complex, which cleaves pre-rRNA sequences (By similarity). (167 aa) |
| | Sec13 | Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II. Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development. Required for reactivation of transcription after heat shock. Required for nuclear import of phosphorylated Mad via importin msk. Has no role i [...] (356 aa) |
| | eIF3a | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (1140 aa) |
| | Rpp21 | Uncharacterized protein, isoform A; Ribonuclease P activity. It is involved in the biological process described with: tRNA processing; tRNA 5'-leader removal. (183 aa) |
| | thoc6 | THO complex subunit 6; The THO complex is required for cell proliferation and for proper export of heat-shock mRNAs under heat stress. Belongs to the WD repeat THOC6 family. (350 aa) |
| | Bin1 | Histone deacetylase complex subunit SAP18; Involved in the tethering of the SIN3 complex to core histone proteins. Interacts with bicoid (bcd) to repress transcription of bicoid target genes in the anterior tip of the embryo; a process known as retraction. Interacts with Trl and binds to Polycomb response elements at the bithorax complex. May contribute to the regulation of other homeotic gene expressions. (150 aa) |
