STRINGSTRING
SrpRalpha SrpRalpha Hsc70-3 Hsc70-3 CG9240 CG9240 OXA1L OXA1L Srp68 Srp68 Srp9 Srp9 Sec63 Sec63 Srp19 Srp19 Srp54k Srp54k Trp1 Trp1 twr twr Srp72 Srp72 Spase12 Spase12 CG11110 CG11110 CG13426 CG13426 Sec61beta Sec61beta CG8860 CG8860 Srp14 Srp14 Spase22-23 Spase22-23 SrpRbeta SrpRbeta Spase25 Spase25 Sec61gamma Sec61gamma Sec61alpha Sec61alpha
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SrpRalphaSignal recognition particle receptor subunit alpha homolog; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). May have a role in axonogenesis. (614 aa)
Hsc70-3Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins (By similarity). Acts as a key repressor of the unfolded protein response (UPR) (By similarity). (656 aa)
CG9240Mitochondrial inner membrane protease subunit; Serine-type peptidase activity. It is involved in the biological process described with: protein processing involved in protein targeting to mitochondrion. (166 aa)
OXA1LOXA1L mitochondrial inner membrane protein, isoform A; Membrane insertase activity. It is involved in the biological process described with: protein insertion into mitochondrial inner membrane from matrix; mitochondrial cytochrome c oxidase assembly; respiratory chain complex IV assembly; protein insertion into membrane. (441 aa)
Srp68Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Srp68 binds the 7S RNA, Srp72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (By similarity). (604 aa)
Srp9Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Srp9 together with Srp14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of Srp9 and Srp14 is required for SRP RNA binding (By similarity). (77 aa)
Sec63Secretory 63; Protein transmembrane transporter activity; RNA binding. It is involved in the biological process described with: SRP-dependent cotranslational protein targeting to membrane; posttranslational protein targeting to endoplasmic reticulum membrane; posttranslational protein targeting to membrane, translocation. (753 aa)
Srp19Signal recognition particle 19 kDa protein; Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP. (160 aa)
Srp54kSignal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (508 aa)
Trp1Translocation protein 1, isoform B; Protein transmembrane transporter activity. It is involved in the biological process described with: posttranslational protein targeting to membrane, translocation. (428 aa)
twrSignal peptidase complex catalytic subunit SEC11; Serine-type peptidase activity; peptidase activity. It is involved in the biological process described with: signal peptide processing. (185 aa)
Srp72Signal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP72 family. (650 aa)
Spase12Signal peptidase complex subunit 1; Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (98 aa)
CG11110IP06605p; Serine-type peptidase activity. It is involved in the biological process described with: signal peptide processing; protein processing involved in protein targeting to mitochondrion; mitochondrial respiratory chain complex assembly. (171 aa)
CG13426P-P-bond-hydrolysis-driven protein transmembrane transporter activity; protein transmembrane transporter activity. It is involved in the biological process described with: posttranslational protein targeting to membrane, translocation. (105 aa)
Sec61betaSec61 beta subunit (Sec61beta) encodes a protein involved in the regulation of autophagy. (100 aa)
CG8860Protein transport protein Sec61 gamma-1 subunit; Necessary for protein translocation in the endoplasmic reticulum. (68 aa)
Srp14Signal recognition particle protein 14; Endoplasmic reticulum signal peptide binding; 7S RNA binding. It is involved in the biological process described with: SRP-dependent cotranslational protein targeting to membrane; protein targeting to ER. (109 aa)
Spase22-23Signal peptidase complex subunit 3; Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (179 aa)
SrpRbetaSignal recognition particle receptor beta (SrpRbeta) encodes a protein that contributes to cuticle secretion by epidermal cells. (244 aa)
Spase25Signal peptidase complex subunit 2; Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (199 aa)
Sec61gammaProtein transport protein Sec61 gamma-2 subunit; Necessary for protein translocation in the endoplasmic reticulum. (68 aa)
Sec61alphaSec61 alpha subunit (Sec61alpha) encodes a subunit of the the translocon, a protein-conducting channel that mediates the co-translational transport of nascent polypeptides into the endoplasmic reticulum. It is a subunit of the Sec61 heterotrimer that forms the core of translocon channel. (476 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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