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Ocrl Ocrl sktl sktl CG10082 CG10082 CG13526 CG13526 CG3530 CG3530 Pi3K59F Pi3K59F CG13898 CG13898 Sac1 Sac1 Eip63F-1 Eip63F-1 Pis Pis sl sl CG17026 CG17026 CG17028 CG17028 INPP5E INPP5E Pi3K68D Pi3K68D CG6707 CG6707 CG31960 CG31960 Ipk2 Ipk2 CG9389 CG9389 Itpr Itpr IP3K1 IP3K1 Ipp Ipp CG5024 CG5024 CG17770 CG17770 inaC inaC Pkc53E Pkc53E Dgkepsilon Dgkepsilon azot azot CG30378 CG30378 fab1 fab1 Pi4KIIalpha Pi4KIIalpha Plc21C Plc21C PIP4K PIP4K CG3632 CG3632 Ipk1 Ipk1 CG42271 CG42271 5PtaseI 5PtaseI Pten Pten norpA norpA Acam Acam CG34384 CG34384 PIP5K59B PIP5K59B Cam Cam CG9391 CG9391 Synj Synj Dgk Dgk CG31140 CG31140 Pi3K21B Pi3K21B Pi4KIIIalpha Pi4KIIIalpha CG17029 CG17029 CG17027 CG17027 rdgA rdgA Pi3K92E Pi3K92E EDTP EDTP mtm mtm CG15743 CG15743 IP3K2 IP3K2 Cds Cds fwd fwd
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OcrlOculocerebrorenal syndrome of Lowe (Ocrl) encodes an inositol polyphosphate 5-phosphatase that regulates PtdIns(4,5)P2 homeostasis by dephosphorylating PtdIns(4,5)P2 on endocytic compartments. In vitro experiments also suggest a role of the product of Ocrl during cytokinesis. (850 aa)
sktlSkittles, isoform A; Skittles (sktl) encodes the major Phosphatidylinositol 4-Phosphate-5 kinase (PI4P5K), catalysing the formation of phosphoinositol-4,5-bisphosphate (PIP4,5). The sktl product is involved in many cellular processes involving (PIP4,5), such as endocytosis. It plays an important role in cell polarity by controlling the localization of the product encoded by baz. (792 aa)
CG10082Kinase activity; inositol hexakisphosphate kinase activity. It is involved in the biological process described with: phosphatidylinositol phosphorylation; inositol phosphate biosynthetic process; Belongs to the inositol phosphokinase (IPK) family. (902 aa)
CG13526Uncharacterized protein; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. (154 aa)
CG3530GH09546p; Metal ion binding; phosphatidylinositol-3-phosphatase activity; protein tyrosine phosphatase activity; phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity. It is involved in the biological process described with: phosphatidylinositol dephosphorylation; mitotic cell cycle; regulation of autophagy. (761 aa)
Pi3K59FPhosphatidylinositol 3-kinase catalytic subunit type 3; Phosphotidylinositol 3 kinase 59F (Pi3K59F) encodes a lipid kinase that is required for formation of Phosphatidylinositol 3-phosphate. It functions in a core protein complex that includes the products of Atg6 and Vps15. It is involved in the control of vesicle trafficking, including autophagy, endocytosis and phagocytosis. (949 aa)
CG13898GEO12020p1; Calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling. (151 aa)
Sac1Sac1 phosphatase (Sac1) encodes a lipid phosphatase that dephosphorylates phosphatidylinositol 4-phosphate to generate phosphatidylinositol. It is involved in dorsal closure, Hedgehog signaling and axon guidance. (592 aa)
Eip63F-1Calcium-binding protein E63-1; Ecdysone-induced protein 63F 1 (Eip63F-1) encodes a member of the EF-hand family of Ca[2+]-binding proteins, induced directly by 20-hydroxyecdysone in late third instar larvae. It is responsible for formation of the 63F early puff in the polytene chromosomes. (193 aa)
PisCDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content (By similarity). The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (By similarity). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5- bisphosphate (PtdInsP2) from phosphatidic acid (PA) and maintenance of its steady supply during signaling, thus playing [...] (224 aa)
sl1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Small wing (sl) encodes a phosphatidylinositol-specific phospholiase type C that is required as a general modulator for growth downstream of the insulin pathway, and interacts with the Ras-MAPK pathway. (1236 aa)
CG17026Inositol-1-monophosphatase; Inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: inositol metabolic process; signal transduction; inositol phosphate dephosphorylation; phosphatidylinositol phosphorylation. (284 aa)
CG17028Inositol-1-monophosphatase; Inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: inositol phosphate dephosphorylation; phosphatidylinositol phosphorylation; signal transduction; inositol metabolic process. (284 aa)
INPP5EInositol polyphosphate 5-phosphatase E; Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) to phosphatidylinositol 4-phosphate (PI-4-P). By controlling the phosphoinositide composition of the cilia membrane of auditory receptor neurons, regulates the cilia localization of ktub and consequently the transient receptor potential channels iav and nompC. Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type IV family. (747 aa)
Pi3K68DPhosphotidylinositol 3 kinase 68D (Pi3K68D) encodes a phosphatidylinositol kinase involved in the organization of the cortical actin cytoskeleton and the regulation of the Egfr signaling pathway; Belongs to the PI3/PI4-kinase family. (1876 aa)
CG6707Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (266 aa)
CG31960GEO02651p1; Enzyme regulator activity; calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling; microtubule cytoskeleton organization; Belongs to the calmodulin family. (148 aa)
Ipk2Kinase; Ipk2 (Ipk2) encodes a kinase involved in imaginal disc development and biosynthesis of inositol phosphate; Belongs to the inositol phosphokinase (IPK) family. (309 aa)
CG9389GH15479p; Inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: inositol metabolic process; signal transduction; inositol phosphate dephosphorylation; phosphatidylinositol phosphorylation. (596 aa)
ItprInositol 1,4,5,-trisphosphate receptor (Itpr) encodes an intracellular ligand gated calcium channel. It functions downstream of G-protein coupled receptors that activate Gq/PLCbeta signaling and generate inositol tris-phosphate. Itpr depletion affects ecdysone release, response to nutritional stress, lipid metabolism and flight; Belongs to the InsP3 receptor family. (2837 aa)
IP3K1Kinase; Inositol 1,4,5-triphosphate kinase 1 (IP3K1) encodes a protein involved in response to oxidative stress; Belongs to the inositol phosphokinase (IPK) family. (441 aa)
IppInositol polyphosphate 1-phosphatase (Ipp) encodes a protein involved in synaptic transmission and inositol metabolism regulation. (375 aa)
CG5024GEO08667p1; Calcium ion binding; enzyme regulator activity. It is involved in the biological process described with: calcium-mediated signaling; microtubule cytoskeleton organization. (165 aa)
CG17770MIP05401p; Enzyme regulator activity; calcium ion binding. It is involved in the biological process described with: calcium-mediated signaling; microtubule cytoskeleton organization. (164 aa)
inaCProtein kinase C, eye isozyme; This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. This isozyme is a negative regulator of the visual transduction cascade and has been shown to be required for photoreceptor cell inactivation and light adaptation. Negative regulation is dependent on interaction with scaffolding protein inaD. Acts in a hh-signaling pathway which regulates the Duox- dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the [...] (700 aa)
Pkc53EProtein kinase C, brain isozyme; PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins (By similarity). PKC also serves as the receptor for phorbol esters, a class of tumor promoters (By similarity). Acts in a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection ; Belongs to the prote [...] (679 aa)
DgkepsilonDiacyl glycerol kinase epsilon (Dgkepsilon) encodes a kinase that plays a key role in the metabolism of diacylglycerol by converting diacylglycerol into phosphatidic acid. (534 aa)
azotGEO08584p1; Ahuizotl (azot) encodes a calcium dependent protein that ensures the elimination of less fit cells. Fitness-based cell culling is used to maintain tissue health, delay aging, and extend lifespan. During development it also prevents malformations; Belongs to the calmodulin family. (148 aa)
CG30378Uncharacterized protein; Calcium ion binding. (148 aa)
fab1Putative 1-phosphatidylinositol 3-phosphate 5-kinase; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Has a role at a late stage in endosome- related membrane trafficking, at a point when signal termination has occurred. Is not required for receptor silencing. (1809 aa)
Pi4KIIalphaPi4KIIalpha, isoform A; Pi4KIIalpha (Pi4KIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. It contributes to membrane trafficking in the larval salivary gland. (710 aa)
Plc21C1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1318 aa)
PIP4KPhosphatidylinositol 5-phosphate 4-kinase (PIP4K) encodes an enzyme that mediates the conversion of phosphatidylinositol 4 phosphate to phosphatidylinositol 4,5 bisphosphate. It has been implicated in the regulation of mTOR signalling and control of cell size. (404 aa)
CG3632LD11744p; It is involved in the biological process described with: peptidyl-tyrosine dephosphorylation; phosphatidylinositol dephosphorylation; regulation of autophagy. (1250 aa)
Ipk1Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (716 aa)
CG42271Uncharacterized protein, isoform C; Phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity. (1280 aa)
5PtaseI5PtaseI, isoform C; Inositol-polyphosphate 5-phosphatase activity. It is involved in the biological process described with: inositol phosphate dephosphorylation; inositol phosphate-mediated signaling; phosphatidylinositol dephosphorylation. (699 aa)
PtenPhosphatase and tensin homolog (Pten) encodes a dual lipid and protein phosphatase that primarily counters the effects of the insulin-regulated lipid kinase, encoded by Pi3K92E. It inhibits cell growth, cell proliferation and cellular events controlling cytoskeletal and junctional rearrangements. (514 aa)
norpA1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (By similarity). Essential component of the phototransduction pathway. Essential downstream component of a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent product [...] (1095 aa)
AcamCalmodulin-related protein 97A; May be involved in calcium-mediated signal transduction. (148 aa)
CG34384Diacylglycerol kinase eta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). (1936 aa)
PIP5K59BPhosphatidylinositol 4-phosphate 5-kinase at 59B, isoform E. (891 aa)
CamCalmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes. Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance. (149 aa)
CG9391Inositol-1-monophosphatase; Inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: phosphatidylinositol phosphorylation; inositol phosphate dephosphorylation; inositol metabolic process; signal transduction. (278 aa)
SynjSynaptojanin, isoform A; Synaptojanin (Synj) encodes a synaptic Phosphoinositide phosphate (PtdInsP) phosphatase that catalyzes the hydrolysis of phosphate groups from phosphorylated inositols. It is recruited or stabilized by the product of EndoA to endocytic membranes, and it catalyzes dephosphorylation reactions implicated in the uncoating of nascent endocytic vesicles. When the product of Synj dephosphorylates phosphoinositides on nascent vesicles, endocytic adaptors with affinity for these lipids will leave the membrane to uncoat the vesicle. (1218 aa)
DgkDiacylglycerol kinase 1; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity (By similarity). May have a role in the development of the embryonic nervous system and the function of the adult nervous system and muscle; regulating signal transduction in neurons. (1230 aa)
CG31140Nucleic acid binding; NAD+ kinase activity; diacylglycerol kinase activity. (1571 aa)
Pi3K21BPi3K21B, isoform B; Pi3K21B (Pi3K21B) encodes an adaptor protein (p60) that binds the product of Pi3K92E to form the functional cllass IA phosphoinositide 3-kinase. This heterodimeric kinase is involved in phosphatidylinositol phosphorylation and regulates cell size and proliferation. (496 aa)
Pi4KIIIalphaPhosphatidylinositol 4-kinase III alpha (PI4KIIIalpha) encodes a lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. Its roles include localization of plasma membrane-associated cytoskeletal and membrane trafficking proteins, Hippo signaling regulation and polarization of developing oocytes; Belongs to the PI3/PI4-kinase family. (2154 aa)
CG17029Inositol-1-monophosphatase; Inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: inositol metabolic process; signal transduction; inositol phosphate dephosphorylation; phosphatidylinositol phosphorylation. (284 aa)
CG17027Inositol-1-monophosphatase; Inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: signal transduction; inositol metabolic process; inositol phosphate dephosphorylation; phosphatidylinositol phosphorylation. (288 aa)
rdgARetinal degeneration A (rdgA) encodes a diacylglycerol kinase that mediates the conversion of diacylglycerol to phosphatidic acid. It contributes to phospholipase C based signalling reactions, controlling ion channel activity and protein transport. (1462 aa)
Pi3K92EPhosphoinositide 3-kinase, Dp110; Pi3K92E (Pi3K92E) encodes the catalytic subunit of a class I phosphatidylinositol 3-kinase that functions downstream of the product of InR and other receptors during several processes, including cell and tissue growth; Belongs to the PI3/PI4-kinase family. (1088 aa)
EDTPEgg-derived tyrosine phosphatase, isoform C; Phosphatidylinositol-3-phosphatase activity; protein tyrosine phosphatase activity. It is involved in the biological process described with: dephosphorylation; oogenesis. (754 aa)
mtmMyotubularin, isoform A; Myotubularin (mtm) encodes a phosphatidylinositol-3-phosphatase that, together with the products of Sbf and Rab21, regulates macrophage protrusion formation. It is involved in cortical actin cytoskeleton organization, chromosome segregation and endocytic recycling. (619 aa)
CG15743Inositol-1,4-bisphosphate 1-phosphatase activity; 3'-nucleotidase activity; inositol monophosphate 1-phosphatase activity. It is involved in the biological process described with: signal transduction; dephosphorylation; phosphate-containing compound metabolic process; phosphatidylinositol phosphorylation; phosphatidylinositol biosynthetic process. (355 aa)
IP3K2Kinase; Inositol 1,4,5-triphosphate kinase 2 (IP3K2) encodes a kinase that regulates calcium levels by influencing IP3 signaling; Belongs to the inositol phosphokinase (IPK) family. (691 aa)
CdsPhosphatidate cytidylyltransferase, photoreceptor-specific; Catalyzes the conversion of phosphatidic acid (PA) to CDP- diacylglycerol (CDP-DAG), an important precursor for the synthesis of phosphatidylinositol (PtdIns) and phosphatidylglycerol (PG). Required for the regeneration of the signaling molecule phosphatidylinositol 4,5-bisphosphate (PtdInsP2) from PA and maintenance of its steady supply during signaling thus playing an essential role during phospholipase C-mediated transduction. In the salivary glands and possibly other adipose tissues, function is essential for regulating ce [...] (447 aa)
fwdFour wheel drive (fwd) encodes a Golgi-localized lipid kinase that synthesizes phosphatidylinositol 4-phosphate from phosphatidylinositol. It is involved in spermatocyte cytokinesis and male fertility; Belongs to the PI3/PI4-kinase family. (1682 aa)
Your Current Organism:
Drosophila melanogaster
NCBI taxonomy Id: 7227
Other names: D. melanogaster, Diptera sp. DNAS-2A9-224646, Sophophora melanogaster, fruit fly
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