Beclin-1-like protein; Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis.

AT16536p; Buffy (Buffy) encodes one of the two Bcl-2 family members in Drosophila (the other being the product of Debcl). Its loss has been linked to altered energy metabolism in larvae.

Beclin-1-like protein; Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis.

Cytochrome c-1; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Beclin-1-like protein; Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis.

Cytochrome c-2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

Beclin-1-like protein; Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis.

Caspase-1 subunit p13; Death caspase-1 (Dcp-1) encodes an effector caspase that cleaves specific proteins during apoptosis. It typically acts downstream of the initiator caspase encoded by Dronc. It is also involved in non-apoptotic processes such as autophagy.

Beclin-1-like protein; Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis.

Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death.

Beclin-1-like protein; Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis.

Death executioner caspase related to Apopain/Yama (Decay) encodes one of the seven members of the caspase family of cysteine proteases. It has substrate specificity similar to the effector caspases encoded by Drice and Dcp-1; Belongs to the peptidase C14A family.

Beclin-1-like protein; Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis.

Death-associated inhibitor of apoptosis 1; Anti-apoptotic protein which functions as a caspase regulator, using its E3 ubiquitin-protein ligase activity to smother caspase activity. Binds, ubiquitinates and inactivates initiator caspase Dronc, and effector caspases Drice and Dcp-1. Acts as a Nedd8- E3 ubiquitin-protein ligase for Drice. Suppresses apoptosis by targeting the apoptosome for ubiquitination and inactivation. Plays an important role in cell motility. Overexpression suppresses rpr and hid- dependent cell death in the eye. Interaction of Diap1 with Dronc is required to suppre [...]

Beclin-1-like protein; Autophagy-related 6 (Atg6) encodes a component of the Vps34 complex that is required for the formation of PI3P, and functions in vesicle trafficking including autophagy and endocytosis.

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

BIR repeat containing ubiquitin-conjugating enzyme (Bruce) encodes a BIR domain containing anti-apoptotic protein of the inhibitor of apoptosis (IAP) protein family. It blocks apoptosis in part by binding to and ubiquitylating pro-apoptotic proteins such as the product of rpr. Bruce mutants are viable, but are vulnerable to apoptosis and show defects in spermatid differentiation.

Cytochrome c-1; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

BIR repeat containing ubiquitin-conjugating enzyme (Bruce) encodes a BIR domain containing anti-apoptotic protein of the inhibitor of apoptosis (IAP) protein family. It blocks apoptosis in part by binding to and ubiquitylating pro-apoptotic proteins such as the product of rpr. Bruce mutants are viable, but are vulnerable to apoptosis and show defects in spermatid differentiation.

Cytochrome c-2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.

BIR repeat containing ubiquitin-conjugating enzyme (Bruce) encodes a BIR domain containing anti-apoptotic protein of the inhibitor of apoptosis (IAP) protein family. It blocks apoptosis in part by binding to and ubiquitylating pro-apoptotic proteins such as the product of rpr. Bruce mutants are viable, but are vulnerable to apoptosis and show defects in spermatid differentiation.

Death-associated APAF1-related killer, isoform B; Death-associated APAF1-related killer (Dark) encodes an essential component of the apoptosome. The products of Dark and Dronc form a pivotal holoenzyme required for apoptotic cell death with the products of Dark acting as an adaptor of the multimeric complex.

BIR repeat containing ubiquitin-conjugating enzyme (Bruce) encodes a BIR domain containing anti-apoptotic protein of the inhibitor of apoptosis (IAP) protein family. It blocks apoptosis in part by binding to and ubiquitylating pro-apoptotic proteins such as the product of rpr. Bruce mutants are viable, but are vulnerable to apoptosis and show defects in spermatid differentiation.

Caspase-1 subunit p13; Death caspase-1 (Dcp-1) encodes an effector caspase that cleaves specific proteins during apoptosis. It typically acts downstream of the initiator caspase encoded by Dronc. It is also involved in non-apoptotic processes such as autophagy.

BIR repeat containing ubiquitin-conjugating enzyme (Bruce) encodes a BIR domain containing anti-apoptotic protein of the inhibitor of apoptosis (IAP) protein family. It blocks apoptosis in part by binding to and ubiquitylating pro-apoptotic proteins such as the product of rpr. Bruce mutants are viable, but are vulnerable to apoptosis and show defects in spermatid differentiation.

Death executioner Bcl-2 (Debcl) encodes a pro-apoptotic member of the Bcl-2 family involved in programmed cell death.

BIR repeat containing ubiquitin-conjugating enzyme (Bruce) encodes a BIR domain containing anti-apoptotic protein of the inhibitor of apoptosis (IAP) protein family. It blocks apoptosis in part by binding to and ubiquitylating pro-apoptotic proteins such as the product of rpr. Bruce mutants are viable, but are vulnerable to apoptosis and show defects in spermatid differentiation.

Death executioner caspase related to Apopain/Yama (Decay) encodes one of the seven members of the caspase family of cysteine proteases. It has substrate specificity similar to the effector caspases encoded by Drice and Dcp-1; Belongs to the peptidase C14A family.

BIR repeat containing ubiquitin-conjugating enzyme (Bruce) encodes a BIR domain containing anti-apoptotic protein of the inhibitor of apoptosis (IAP) protein family. It blocks apoptosis in part by binding to and ubiquitylating pro-apoptotic proteins such as the product of rpr. Bruce mutants are viable, but are vulnerable to apoptosis and show defects in spermatid differentiation.

GEO07887p1; Deterin (Det) encodes a component of the chromosomal passenger complex involved in regulation of apoptosis and cytokinesis.

BIR repeat containing ubiquitin-conjugating enzyme (Bruce) encodes a BIR domain containing anti-apoptotic protein of the inhibitor of apoptosis (IAP) protein family. It blocks apoptosis in part by binding to and ubiquitylating pro-apoptotic proteins such as the product of rpr. Bruce mutants are viable, but are vulnerable to apoptosis and show defects in spermatid differentiation.

Death-associated inhibitor of apoptosis 1; Anti-apoptotic protein which functions as a caspase regulator, using its E3 ubiquitin-protein ligase activity to smother caspase activity. Binds, ubiquitinates and inactivates initiator caspase Dronc, and effector caspases Drice and Dcp-1. Acts as a Nedd8- E3 ubiquitin-protein ligase for Drice. Suppresses apoptosis by targeting the apoptosome for ubiquitination and inactivation. Plays an important role in cell motility. Overexpression suppresses rpr and hid- dependent cell death in the eye. Interaction of Diap1 with Dronc is required to suppre [...]

BIR repeat containing ubiquitin-conjugating enzyme (Bruce) encodes a BIR domain containing anti-apoptotic protein of the inhibitor of apoptosis (IAP) protein family. It blocks apoptosis in part by binding to and ubiquitylating pro-apoptotic proteins such as the product of rpr. Bruce mutants are viable, but are vulnerable to apoptosis and show defects in spermatid differentiation.

Death-associated inhibitor of apoptosis 2; Required for activation of NF-kappaB transcription factors in the immune deficiency (Imd) signaling cascade which is essential for innate immune responses upon infection by Gram-negative bacteria. Promotes cytoplasmic cleavage of Rel and its translocation to the nucleus where it drives expression of antimicrobial peptides. Binds, polyubiquitinates and activates Dredd which is required for Rel- mediated induction of antimicrobial peptides. Anti- apoptotic protein which binds, ubiquitinates and inactivates the effector caspase Drice. Suppresses [...]

BIR repeat containing ubiquitin-conjugating enzyme (Bruce) encodes a BIR domain containing anti-apoptotic protein of the inhibitor of apoptosis (IAP) protein family. It blocks apoptosis in part by binding to and ubiquitylating pro-apoptotic proteins such as the product of rpr. Bruce mutants are viable, but are vulnerable to apoptosis and show defects in spermatid differentiation.

Caspase-8 subunit p10; Effector of the programmed cell death (PCD) activators rpr, grim and hid. May play an apoptotic role in the germline as well as soma. Fadd interacts with Dredd to promote cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis. Plays a role in the innate immune response. Required for resistance to Gram-negative bacterial infection. Diap2-mediated ubiquitination of Dredd is critical for processing of imd and rel and the subsequent expression of antimicrobial genes such as DptA. Belongs to the peptidase C14A family.

BIR repeat containing ubiquitin-conjugating enzyme (Bruce) encodes a BIR domain containing anti-apoptotic protein of the inhibitor of apoptosis (IAP) protein family. It blocks apoptosis in part by binding to and ubiquitylating pro-apoptotic proteins such as the product of rpr. Bruce mutants are viable, but are vulnerable to apoptosis and show defects in spermatid differentiation.

Caspase subunit p12; Death related ICE-like caspase (Drice) encodes a major effector apoptotic caspase. It is essential for both developmental and damaged induced cell death, as well as several non-apoptotic vital cellular processes. It is activated by the product of Dark and the initiator caspase encoded by Dronc and is inhibited by the inhibitor of apoptosis encoded by Diap1; Belongs to the peptidase C14A family.

BIR repeat containing ubiquitin-conjugating enzyme (Bruce) encodes a BIR domain containing anti-apoptotic protein of the inhibitor of apoptosis (IAP) protein family. It blocks apoptosis in part by binding to and ubiquitylating pro-apoptotic proteins such as the product of rpr. Bruce mutants are viable, but are vulnerable to apoptosis and show defects in spermatid differentiation.

Caspase Nc subunit 1; Involved in the activation cascade of caspases responsible for apoptosis execution. Effector of steroid-mediated apoptosis during insect metamorphosis. Overexpression promotes programmed cell death. Interaction with Diap1 is required to suppress Dronc-mediated cell death; via Diap1-mediated ubiquitination of Dronc. Rate-limiting caspase in rpr and hid death pathway.