(106 nodes) Regulation of protein kinase activity network (Drosophila persimilis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DperGL19403	GL19403. (720 aa)
	DperGL19431	GL19431; Belongs to the cyclin family. (338 aa)
	DperGL18583	GL18583; Belongs to the cyclin family. (439 aa)
	DperGL10760	GL10760. (184 aa)
	DperGL23309	GL23309. (461 aa)
	DperGL11351	GL11351. (1185 aa)
	DperGL10703	GL10703; Belongs to the cyclin family. (559 aa)
	DperGL11391	GL11391. (231 aa)
	DperGL10693	GL10693. (578 aa)
	DperGL11442	GL11442. (570 aa)
	DperGL10610	GL10610. (471 aa)
	DperGL10567	GL10567. (372 aa)
	DperGL11027	GL11027. (580 aa)
	DperGL11159	GL11159. (1182 aa)
	DperGL22162	GL22162. (1012 aa)
	Ras85D	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa)
	DperGL22237	GL22237. (392 aa)
	DperGL17185	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (320 aa)
	DperGL17154	GL17154. (244 aa)
	DperGL17386	GL17386. (570 aa)
	DperGL16736	GL16736. (626 aa)
	DperGL25593	Small ubiquitin-related modifier. (90 aa)
	DperGL26256	GL26256; Belongs to the cyclin family. (411 aa)
	DperGL26266	GL26266. (79 aa)
	DperGL25867	GL25867. (1126 aa)
	DperGL25689	GL25689. (282 aa)
	DperGL26126	GL26126. (410 aa)
	DperGL26163	GL26163. (408 aa)
	DperGL25606	GL25606. (438 aa)
	DperGL12276	GL12276. (1279 aa)
	DperGL12275	GL12275. (793 aa)
	DperGL12136	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (91 aa)
	DperGL23544	GL23544. (561 aa)
	DperGL13938	GL13938. (367 aa)
	DperGL13555	GL13555; Belongs to the cyclin family. (554 aa)
	DperGL14019	GL14019. (765 aa)
	DperGL13796	GL13796. (3706 aa)
	DperGL13647	GL13647; Belongs to the cyclin family. (356 aa)
	DperGL15279	GL15279; Belongs to the cyclin family. (395 aa)
	DperGL15107	GL15107. (453 aa)
	DperGL25034	GL25034; Belongs to the cyclin family. (1130 aa)
	DperGL25165	GL25165. (236 aa)
	DperGL24864	GL24864; Belongs to the cyclin family. (311 aa)
	DperGL25303	GL25303. (390 aa)
	DperGL14332	GL14332; Belongs to the protein kinase superfamily. (350 aa)
	DperGL26029	GL26029. (201 aa)
	DperGL24352	GL24352. (377 aa)
	DperGL26623	GL26623. (54 aa)
	DperGL12992	GL12992. (590 aa)
	DperGL12991	GL12991. (1370 aa)
	Pgam5	Serine/threonine-protein phosphatase Pgam5, mitochondrial; Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity (By similarity). (289 aa)
	DperGL20152	GL20152. (500 aa)
	DperGL20153	GL20153. (202 aa)
	DperGL19933	GL19933. (856 aa)
	DperGL27142	GL27142; Belongs to the PI3/PI4-kinase family. (1103 aa)
	DperGL22818	GL22818. (304 aa)
	DperGL22884	GL22884. (493 aa)
	DperGL14954	GL14954. (1648 aa)
	DperGL17991	GL17991. (476 aa)
	DperGL26894	GL26894. (987 aa)
	DperGL13430	GL13430. (305 aa)
	sws	Neuropathy target esterase sws; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity); Belongs to t [...] (1435 aa)
	DperGL20814	GL20814. (237 aa)
	DperGL20815	GL20815; Belongs to the cyclin family. (306 aa)
	DperGL18265	GL18265. (191 aa)
	DperGL10190	GL10190. (507 aa)
	DperGL16147	GL16147. (845 aa)
	DperGL16078	GL16078. (146 aa)
	DperGL24687	GL24687. (57 aa)
	DperGL24706	GL24706. (860 aa)
	DperGL20555	GL20555. (192 aa)
	DperGL11832	GL11832. (351 aa)
	DperGL13251	GL13251; Belongs to the cyclin family. (725 aa)
	DperGL13260	GL13260. (607 aa)
	DperGL12722	GL12722. (339 aa)
	DperGL12853	GL12853. (1654 aa)
	DperGL12854	GL12854. (1888 aa)
	DperGL20997	GL20997. (278 aa)
	DperGL23669	GL23669. (357 aa)
	DperGL15988	GL15988. (357 aa)
	DperGL16336	GL16336. (1090 aa)
	DperGL27059	GL27059. (320 aa)
	DperGL19732	GL19732. (1610 aa)
	DperGL24555	GL24555. (307 aa)
	DperGL11911	GL11911. (490 aa)
	DperGL15439	GL15439; Belongs to the cyclin family. (721 aa)
	DperGL20678	GL20678; Belongs to the cyclin family. (467 aa)
	DperGL10073	GL10073. (817 aa)
	DperGL23886	GL23886. (282 aa)
	GL23610	Lateral signaling target protein 2 homolog; Negative regulator of epidermal growth factor receptor (EGFR) signaling. (1009 aa)
	DperGL21032	GL21032. (65 aa)
	DperGL18994	GL18994. (220 aa)
	DperGL24474	GL24474. (210 aa)
	DperGL23474	Protein BCCIP homolog; Belongs to the BCP1 family. (296 aa)
	DperGL18506	GL18506. (274 aa)
	DperGL18491	GL18491. (436 aa)
	DperGL18974	Cyclin-dependent kinase 5 activator. (441 aa)
	DperGL24215	GL24215. (219 aa)
	DperGL24192	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (466 aa)
	DperGL19174	GL19174. (546 aa)
	DperGL18484	GL18484. (1816 aa)
	DperGL24513	GL24513. (1374 aa)
	DperGL18876	GL18876; Belongs to the eukaryotic ribosomal protein P1/P2 family. (112 aa)
	DperGL18835	GL18835. (457 aa)
	DperGL24417	GL24417. (341 aa)
	DperGL23830	GL23830. (589 aa)

Your Current Organism:

Drosophila persimilis

NCBI taxonomy Id: 7234
Other names: D. persimilis

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DperGL10567	DperGL24352	B4GB88	B4GUN6	GL10567.	GL24352.	0.482
DperGL10693	DperGL11442	B4GAK7	B4GAU5	GL10693.	GL11442.	0.978
DperGL10693	DperGL12991	B4GAK7	B4GVD4	GL10693.	GL12991.	0.997
DperGL10693	DperGL12992	B4GAK7	B4GVD3	GL10693.	GL12992.	0.982
DperGL10693	DperGL14954	B4GAK7	B4H090	GL10693.	GL14954.	0.838
DperGL10693	DperGL16147	B4GAK7	B4H5H3	GL10693.	GL16147.	0.485
DperGL10693	DperGL20678	B4GAK7	B4HC70	GL10693.	GL20678; Belongs to the cyclin family.	0.412
DperGL10703	DperGL11159	B4GAH8	B4GCN4	GL10703; Belongs to the cyclin family.	GL11159.	0.592
DperGL10703	DperGL12136	B4GAH8	B4GMZ3	GL10703; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.860
DperGL10703	DperGL13251	B4GAH8	B4H777	GL10703; Belongs to the cyclin family.	GL13251; Belongs to the cyclin family.	0.574
DperGL10703	DperGL13430	B4GAH8	B4H300	GL10703; Belongs to the cyclin family.	GL13430.	0.524
DperGL10703	DperGL13555	B4GAH8	B4GN38	GL10703; Belongs to the cyclin family.	GL13555; Belongs to the cyclin family.	0.445
DperGL10703	DperGL14332	B4GAH8	B4GTE4	GL10703; Belongs to the cyclin family.	GL14332; Belongs to the protein kinase superfamily.	0.501
DperGL10703	DperGL15439	B4GAH8	B4HBY9	GL10703; Belongs to the cyclin family.	GL15439; Belongs to the cyclin family.	0.778
DperGL10703	DperGL17185	B4GAH8	B4GG89	GL10703; Belongs to the cyclin family.	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.	0.410
DperGL10703	DperGL18506	B4GAH8	B4G7D3	GL10703; Belongs to the cyclin family.	GL18506.	0.524
DperGL10703	DperGL18583	B4GAH8	B4G9U7	GL10703; Belongs to the cyclin family.	GL18583; Belongs to the cyclin family.	0.447
DperGL10703	DperGL20814	B4GAH8	B4H466	GL10703; Belongs to the cyclin family.	GL20814.	0.719
DperGL10703	DperGL20815	B4GAH8	B4H468	GL10703; Belongs to the cyclin family.	GL20815; Belongs to the cyclin family.	0.732
DperGL10703	DperGL22884	B4GAH8	B4GZY7	GL10703; Belongs to the cyclin family.	GL22884.	0.582