(54 nodes) Regulation of dendrite development network (Drosophila persimilis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DperGL15772	GL15772; Belongs to the STXBP/unc-18/SEC1 family. (447 aa)
	DperGL15771	GL15771; Belongs to the STXBP/unc-18/SEC1 family. (164 aa)
	DperGL18445	GL18445. (559 aa)
	DperGL15286	GL15286. (120 aa)
	DperGL13173	GL13173. (796 aa)
	DperGL24016	GL24016. (511 aa)
	DperGL24017	GL24017. (967 aa)
	DperGL23415	GL23415. (366 aa)
	spas	Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily. (788 aa)
	DperGL24523	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (677 aa)
	DperGL23375	GL23375; Belongs to the small GTPase superfamily. SAR1 family. (193 aa)
	DperGL24389	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (756 aa)
	DperGL19174	GL19174. (546 aa)
	DperGL18691	GL18691. (1119 aa)
	DperGL10711	GL10711. (1362 aa)
	Lis-1	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes. (411 aa)
	DperGL10656	GL10656. (468 aa)
	DperGL11108	GL11108. (250 aa)
	DperGL10941	GL10941. (1565 aa)
	DperGL22058	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (439 aa)
	DperGL22243	GL22243. (1100 aa)
	DperGL16927	GL16927. (196 aa)
	DperGL25857	GL25857; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1260 aa)
	DperGL25683	GL25683. (1612 aa)
	DperGL12220	Non-specific serine/threonine protein kinase. (726 aa)
	DperGL13988	GL13988. (1126 aa)
	DperGL15835	GL15835; Cadherins are calcium-dependent cell adhesion proteins. (3110 aa)
	DperGL14010	GL14010. (1635 aa)
	DperGL25165	GL25165. (236 aa)
	DperGL25225	GL25225. (673 aa)
	DperGL25475	GL25475. (393 aa)
	DperGL12992	GL12992. (590 aa)
	DperGL12991	GL12991. (1370 aa)
	DperGL16369	GL16369. (394 aa)
	DperGL16370	GL16370. (1056 aa)
	DperGL20252	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (499 aa)
	DperGL27278	GL27278. (679 aa)
	DperGL27142	GL27142; Belongs to the PI3/PI4-kinase family. (1103 aa)
	DperGL27344	GL27344. (1929 aa)
	DperGL27353	GL27353. (573 aa)
	DperGL22469	GL22469. (399 aa)
	DperGL13363	GL13363. (1818 aa)
	DperGL12531	GL12531. (370 aa)
	DperGL20789	GL20789. (531 aa)
	DperGL16078	GL16078. (146 aa)
	DperGL16069	GL16069. (336 aa)
	DperGL11836	GL11836. (780 aa)
	DperGL13276	GL13276. (681 aa)
	DperGL12853	GL12853. (1654 aa)
	DperGL12854	GL12854. (1888 aa)
	DperGL21001	GL21001. (891 aa)
	DperGL18182	GL18182. (513 aa)
	DperGL15676	GL15676; Belongs to the protein kinase superfamily. (457 aa)
	DperGL11879	GL11879. (1027 aa)

Your Current Organism:

Drosophila persimilis

NCBI taxonomy Id: 7234
Other names: D. persimilis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DperGL10711	DperGL25475	B4GAG0	B4GU80	GL10711.	GL25475.	0.652
DperGL10711	DperGL27344	B4GAG0	B4GZD1	GL10711.	GL27344.	0.551
DperGL10941	DperGL27344	B4GCN7	B4GZD1	GL10941.	GL27344.	0.550
DperGL11836	DperGL24389	B4H6Y0	B4G5L6	GL11836.	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	0.770
DperGL11879	DperGL13988	B4HBV9	B4GNB6	GL11879.	GL13988.	0.671
DperGL11879	DperGL19174	B4HBV9	B4G7J9	GL11879.	GL19174.	0.640
DperGL11879	DperGL25475	B4HBV9	B4GU80	GL11879.	GL25475.	0.674
DperGL11879	DperGL27344	B4HBV9	B4GZD1	GL11879.	GL27344.	0.443
DperGL11879	DperGL27353	B4HBV9	B4GZF8	GL11879.	GL27353.	0.490
DperGL12220	DperGL12991	B4GMK7	B4GVD4	Non-specific serine/threonine protein kinase.	GL12991.	0.886
DperGL12220	DperGL12992	B4GMK7	B4GVD3	Non-specific serine/threonine protein kinase.	GL12992.	0.886
DperGL12220	DperGL16078	B4GMK7	B4H5K8	Non-specific serine/threonine protein kinase.	GL16078.	0.520
DperGL12220	DperGL19174	B4GMK7	B4G7J9	Non-specific serine/threonine protein kinase.	GL19174.	0.936
DperGL12220	DperGL27142	B4GMK7	B4GZD0	Non-specific serine/threonine protein kinase.	GL27142; Belongs to the PI3/PI4-kinase family.	0.921
DperGL12220	DperGL27344	B4GMK7	B4GZD1	Non-specific serine/threonine protein kinase.	GL27344.	0.420
DperGL12531	DperGL16069	B4H3H5	B4H5M5	GL12531.	GL16069.	0.909
DperGL12531	DperGL20252	B4H3H5	B4GXK5	GL12531.	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.	0.400
DperGL12531	DperGL22058	B4H3H5	B4GEQ7	GL12531.	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.	0.400
DperGL12531	Lis-1	B4H3H5	B4GAJ1	GL12531.	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes.	0.965
DperGL12853	DperGL12854	B4H802	B4H804	GL12853.	GL12854.	0.920