(206 nodes) Modulation of chemical synaptic transmission network (Drosophila persimilis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DperGL23990	GL23990. (869 aa)
	DperGL24016	GL24016. (511 aa)
	DperGL24017	GL24017. (967 aa)
	spas	Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily. (788 aa)
	DperGL24221	GL24221. (739 aa)
	DperGL23254	GL23254. (858 aa)
	DperGL24289	GL24289. (952 aa)
	DperGL24395	GL24395. (233 aa)
	DperGL24404	Nicotinamide-nucleotide adenylyltransferase. (266 aa)
	DperGL20613	GL20613. (65 aa)
	DperGL23741	GL23741; Belongs to the MAGUK family. (487 aa)
	DperGL23746	GL23746. (160 aa)
	DperGL23745	GL23745. (938 aa)
	DperGL19103	GL19103. (356 aa)
	DperGL19110	GL19110. (380 aa)
	DperGL19114	GL19114. (422 aa)
	DperGL19586	GL19586. (621 aa)
	DperGL18531	GL18531. (150 aa)
	DperGL18530	GL18530. (150 aa)
	DperGL18529	GL18529. (148 aa)
	DperGL18528	GL18528. (115 aa)
	DperGL18527	GL18527. (161 aa)
	DperGL18525	GL18525. (157 aa)
	DperGL18503	GL18503. (147 aa)
	DperGL19613	GL19613. (145 aa)
	DperGL18973	GL18973. (736 aa)
	DperGL19174	GL19174. (546 aa)
	DperGL19208	GL19208; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (516 aa)
	DperGL19209	GL19209; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (529 aa)
	DperGL19216	GL19216. (546 aa)
	DperGL18869	Phosphoinositide phospholipase C. (839 aa)
	DperGL18862	GL18862. (784 aa)
	DperGL19509	GL19509. (143 aa)
	DperGL18618	GL18618. (151 aa)
	DperGL19511	GL19511. (155 aa)
	DperGL10772	GL10772. (50 aa)
	DperGL10771	GL10771. (586 aa)
	DperGL10770	GL10770. (354 aa)
	qvr	Protein quiver; Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K(+) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K(+) channel activity and thus reducing neuronal excitability (By similarity). (160 aa)
	DperGL11577	GL11577. (310 aa)
	DperGL11645	GL11645; Belongs to the cullin family. (802 aa)
	DperGL11169	GL11169. (184 aa)
	DperGL10423	GL10423. (604 aa)
	DperGL10413	GL10413. (50 aa)
	DperGL10412	GL10412. (463 aa)
	DperGL10411	GL10411. (289 aa)
	DperGL22343	GL22343. (680 aa)
	DperGL22344	GL22344. (124 aa)
	DperGL22345	GL22345. (675 aa)
	DperGL21808	GL21808. (886 aa)
	DperGL21752	GL21752. (723 aa)
	DperGL22084	GL22084. (546 aa)
	DperGL21706	Tyrosine-protein kinase. (734 aa)
	DperGL20506	GL20506. (438 aa)
	DperGL17285	GL17285. (1268 aa)
	DperGL17187	GL17187. (220 aa)
	DperGL17134	GL17134. (816 aa)
	DperGL17386	GL17386. (570 aa)
	DperGL17476	GL17476. (155 aa)
	DperGL17527	GL17527. (628 aa)
	DperGL16870	GL16870; Belongs to the peptidase C14A family. (323 aa)
	DperGL17605	GL17605; Belongs to the tumor necrosis factor family. (426 aa)
	DperGL17644	GL17644. (432 aa)
	DperGL16762	GL16762. (353 aa)
	DperGL17735	GL17735. (291 aa)
	DperGL16696	Tyrosine-protein kinase. (516 aa)
	DperGL25878	GL25878. (216 aa)
	DperGL26008	GL26008. (263 aa)
	DperGL26009	GL26009. (369 aa)
	DperGL26013	GL26013. (149 aa)
	DperGL25744	GL25744. (294 aa)
	DperGL25742	GL25742. (381 aa)
	DperGL25741	GL25741. (201 aa)
	DperGL26014	GL26014. (380 aa)
	DperGL25668	GL25668. (282 aa)
	DperGL26138	Amino acid transporter. (479 aa)
	DperGL26191	GL26191. (1355 aa)
	DperGL12094	GL12094. (113 aa)
	DperGL12092	GL12092. (104 aa)
	DperGL12091	GL12091. (611 aa)
	DperGL12021	GL12021. (1715 aa)
	DperGL12014	GL12014. (976 aa)
	DperGL12654	GL12654. (2310 aa)
	DperGL12655	GL12655. (1045 aa)
	DperGL12656	GL12656. (888 aa)
	DperGL12314	GL12314. (123 aa)
	DperGL12220	Non-specific serine/threonine protein kinase. (726 aa)
	DperGL12434	GL12434. (482 aa)
	DperGL12162	GL12162. (1249 aa)
	DperGL12450	GL12450. (1444 aa)
	DperGL13493	GL13493; Belongs to the G-protein coupled receptor 1 family. (531 aa)
	DperGL13618	GL13618. (1205 aa)
	DperGL14752	GL14752. (913 aa)
	DperGL15959	GL15959. (779 aa)
	DperGL14311	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (397 aa)
	DperGL14134	GL14134. (1351 aa)
	DperGL16417	GL16417. (949 aa)
	DperGL25094	GL25094. (157 aa)
	DperGL25225	GL25225. (673 aa)
	DperGL25281	GL25281. (533 aa)
	DperGL24820	GL24820. (133 aa)
	DperGL24807	GL24807. (384 aa)
	DperGL24806	GL24806. (241 aa)
	DperGL26310	GL26310. (358 aa)
	DperGL26556	GL26556. (642 aa)
	DperGL26464	GL26464. (236 aa)
	DperGL26447	SNAPIN protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis. (136 aa)
	DperGL26438	GL26438. (473 aa)
	DperGL26369	GL26369. (912 aa)
	DperGL26368	GL26368. (898 aa)
	DperGL26367	GL26367. (223 aa)
	DperGL26647	GL26647. (238 aa)
	DperGL26648	GL26648. (997 aa)
	DperGL26660	GL26660. (242 aa)
	DperGL14269	GL14269. (323 aa)
	DperGL14196	GL14196. (688 aa)
	DperGL24793	GL24793. (1561 aa)
	DperGL24099	GL24099. (1763 aa)
	DperGL24077	GL24077. (1800 aa)
	DperGL24065	GL24065. (901 aa)
	DperGL13001	GL13001. (679 aa)
	DperGL20306	GL20306. (150 aa)
	DperGL20233	GL20233. (494 aa)
	DperGL20232	GL20232. (788 aa)
	DperGL20394	GL20394. (358 aa)
	DperGL19852	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (789 aa)
	DperGL27278	GL27278. (679 aa)
	GL27201	Protein cereblon homolog; Belongs to the CRBN family. (616 aa)
	DperGL27307	GL27307. (302 aa)
	DperGL27142	GL27142; Belongs to the PI3/PI4-kinase family. (1103 aa)
	DperGL27141	GL27141. (902 aa)
	DperGL27140	GL27140. (902 aa)
	DperGL27352	GL27352. (200 aa)
	DperGL22815	GL22815. (908 aa)
	DperSod	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (152 aa)
	DperGL22897	GL22897. (778 aa)
	DperGL14929	GL14929. (427 aa)
	DperGL14928	GL14928. (952 aa)
	DperGL14920	GL14920. (82 aa)
	DperGL14919	GL14919. (237 aa)
	DperGL14985	GL14985. (763 aa)
	DperGL15848	GL15848. (365 aa)
	DperGL15904	GL15904. (395 aa)
	DperGL15816	GL15816. (323 aa)
	DperGL22514	GL22514. (225 aa)
	DperGL22428	GL22428. (117 aa)
	DperGL22427	GL22427. (187 aa)
	DperGL22426	GL22426. (107 aa)
	DperGL17941	Tyrosine-protein kinase. (551 aa)
	DperGL17906	GL17906. (374 aa)
	DperGL17944	GL17944. (452 aa)
	DperGL17945	GL17945. (680 aa)
	DperGL17876	Sorting nexin; Belongs to the sorting nexin family. (561 aa)
	DperGL17981	GL17981. (225 aa)
	DperGL17831	GL17831. (374 aa)
	DperGL26848	GL26848. (3514 aa)
	DperGL26919	GL26919. (323 aa)
	DperGL13314	GL13314. (745 aa)
	DperGL20775	GL20775. (773 aa)
	DperGL20793	GL20793. (158 aa)
	DperGL20864	GL20864. (1165 aa)
	DperGL20865	GL20865. (1074 aa)
	DperGL18265	GL18265. (191 aa)
	DperGL10128	GL10128. (1100 aa)
	DperGL16209	GL16209. (677 aa)
	DperGL16210	GL16210. (423 aa)
	DperGL16211	GL16211. (296 aa)
	DperGL11797	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (218 aa)
	DperGL11825	GL11825; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1740 aa)
	DperGL27022	GL27022. (301 aa)
	DperGL27023	GL27023. (50 aa)
	DperGL26965	GL26965. (187 aa)
	DperGL26964	GL26964. (187 aa)
	DperGL18145	GL18145. (614 aa)
	DperGL18180	GL18180. (895 aa)
	DperGL18390	GL18390. (1700 aa)
	DperGL18383	GL18383. (530 aa)
	DperGL18378	GL18378. (964 aa)
	DperGL18376	GL18376. (711 aa)
	DperGL18377	GL18377. (252 aa)
	DperGL15987	Spectrin beta chain; Belongs to the spectrin family. (2250 aa)
	DperGL22593	GL22593. (122 aa)
	DperGL22604	GL22604. (1357 aa)
	DperGL18427	GL18427. (462 aa)
	DperGL18436	GL18436. (619 aa)
	DperGL18437	GL18437. (182 aa)
	DperGL21385	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (174 aa)
	DperGL21384	GL21384. (337 aa)
	DperGL16304	GL16304. (220 aa)
	DperGL16339	GL16339. (159 aa)
	DperGL13139	GL13139. (1201 aa)
	DperGL20446	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (375 aa)
	DperGL17542	GL17542. (950 aa)
	DperGL15285	GL15285. (197 aa)
	DperGL20794	GL20794. (61 aa)
	DperGL26962	GL26962. (372 aa)
	DperGL25347	GL25347. (148 aa)
	DperGL21438	GL21438. (275 aa)
	DperGL16047	GL16047. (141 aa)
	DperGL21454	GL21454; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (403 aa)
	DperGL18118	GL18118. (117 aa)
	DperGL18055	GL18055. (108 aa)
	DperGL17813	GL17813. (280 aa)
	DperGL12866	GL12866. (308 aa)
	DperGL20687	GL20687. (118 aa)
	DperGL18067	GL18067. (240 aa)

Your Current Organism:

Drosophila persimilis

NCBI taxonomy Id: 7234
Other names: D. persimilis

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DperGL10411	DperGL12021	B4GCT4	B4GLJ1	GL10411.	GL12021.	0.802
DperGL10411	DperGL18436	B4GCT4	B4HA73	GL10411.	GL18436.	0.593
DperGL10411	DperGL18437	B4GCT4	B4HA74	GL10411.	GL18437.	0.456
DperGL10412	DperGL12021	B4GCT3	B4GLJ1	GL10412.	GL12021.	0.802
DperGL10412	DperGL18436	B4GCT3	B4HA73	GL10412.	GL18436.	0.456
DperGL10412	DperGL18437	B4GCT3	B4HA74	GL10412.	GL18437.	0.456
DperGL10413	DperGL12021	B4GCT2	B4GLJ1	GL10413.	GL12021.	0.802
DperGL10413	DperGL18436	B4GCT2	B4HA73	GL10413.	GL18436.	0.456
DperGL10413	DperGL18437	B4GCT2	B4HA74	GL10413.	GL18437.	0.456
DperGL10423	DperGL23741	B4GCR3	B4G609	GL10423.	GL23741; Belongs to the MAGUK family.	0.475
DperGL10423	DperGL24221	B4GCR3	B4G4P6	GL10423.	GL24221.	0.479
DperGL10770	DperGL10771	B4GA38	B4GA37	GL10770.	GL10771.	0.896
DperGL10771	DperGL10770	B4GA37	B4GA38	GL10771.	GL10770.	0.896
DperGL11577	DperGL18383	B4GBR7	B4H9P5	GL11577.	GL18383.	0.504
DperGL11577	DperGL23741	B4GBR7	B4G609	GL11577.	GL23741; Belongs to the MAGUK family.	0.812
DperGL11797	DperSod	B4H743	B4GZN9	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.986
DperGL11825	DperGL16696	B4H763	B4GJ00	GL11825; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Tyrosine-protein kinase.	0.498
DperGL11825	DperGL17386	B4H763	B4GGP8	GL11825; Belongs to the protein kinase superfamily. Tyr protein kinase family.	GL17386.	0.783
DperGL11825	DperGL17941	B4H763	B4H1S6	GL11825; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Tyrosine-protein kinase.	0.537
DperGL11825	DperGL18973	B4H763	B4G7J6	GL11825; Belongs to the protein kinase superfamily. Tyr protein kinase family.	GL18973.	0.603