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DperGL23908 DperGL23908 DperGL23560 DperGL23560 DperGL23517 DperGL23517 DperGL23505 DperGL23505 DperGL24025 DperGL24025 DperGL24182 DperGL24182 DperGL24255 DperGL24255 WRNexo WRNexo DperGL24394 DperGL24394 DperGL23113 DperGL23113 DperGL19555 DperGL19555 DperGL19629 DperGL19629 DperGL18958 DperGL18958 DperGL19650 DperGL19650 DperGL19651 DperGL19651 DperGL19266 DperGL19266 DperGL19475 DperGL19475 DperGL19528 DperGL19528 DperGL11075 DperGL11075 slx1 slx1 DperGL17307 DperGL17307 DperGL17546 DperGL17546 Fen1 Fen1 DperGL25721 DperGL25721 DperGL26094 DperGL26094 DperGL26097 DperGL26097 DperGL26163 DperGL26163 DperGL12075 DperGL12075 DperGL12076 DperGL12076 DperGL12354 DperGL12354 DperGL12271 DperGL12271 DperGL13479 DperGL13479 DperGL14311 DperGL14311 DperGL25194 DperGL25194 DperGL25208 DperGL25208 DperGL25252 DperGL25252 DperGL25269 DperGL25269 DperGL24844 DperGL24844 DperGL25284 DperGL25284 DperGL26495 DperGL26495 DperGL26345 DperGL26345 DperGL14215 DperGL14215 DperGL24569 DperGL24569 DperGL24576 DperGL24576 DperGL14681 DperGL14681 DperGL21219 DperGL21219 DperGL21139 DperGL21139 DperGL21125 DperGL21125 DperGL20619 DperGL20619 DperGL20284 DperGL20284 DperGL19863 DperGL19863 DperGL27179 DperGL27179 DperGL27348 DperGL27348 DperGL27356 DperGL27356 DperGL14973 DperGL14973 DperGL22468 DperGL22468 DperGL17887 DperGL17887 DperGL17969 DperGL17969 DperGL26791 DperGL26791 DperGL20814 DperGL20814 DperGL20815 DperGL20815 DperGL18220 DperGL18220 DperGL10207 DperGL10207 DperGL20217 DperGL20217 DperGL12721 DperGL12721 DperGL12720 DperGL12720 DperGL12719 DperGL12719 DperGL20939 DperGL20939 DperGL18385 DperGL18385 DperGL18384 DperGL18384 DperGL22420 DperGL22420 DperGL21385 DperGL21385 DperGL21384 DperGL21384 DperGL16334 DperGL16334 DperGL21333 DperGL21333 DperGL22221 DperGL22221 DperGL22360 DperGL22360 DperGL21439 DperGL21439 DperGL18118 DperGL18118
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DperGL23908GL23908. (191 aa)
DperGL23560Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
DperGL23517GL23517. (1966 aa)
DperGL23505GL23505. (348 aa)
DperGL24025GL24025. (124 aa)
DperGL24182Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
DperGL24255GL24255. (797 aa)
WRNexoWerner Syndrome-like exonuclease; Essential for the formation of DNA replication focal centers. Has an important role in maintaining genome stability. Has exonuclease activity on both single-stranded and duplex templates bearing overhangs, but not blunt ended duplex DNA, and cleaves in a 3'-5' direction (By similarity); Belongs to the WRNexo family. (355 aa)
DperGL24394GL24394. (1390 aa)
DperGL23113GL23113. (2193 aa)
DperGL19555Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (621 aa)
DperGL19629TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (301 aa)
DperGL18958Importin subunit alpha; Belongs to the importin alpha family. (522 aa)
DperGL19650GL19650. (88 aa)
DperGL19651GL19651. (397 aa)
DperGL19266GL19266; Belongs to the ubiquitin-conjugating enzyme family. (159 aa)
DperGL19475GL19475. (1340 aa)
DperGL19528GL19528. (185 aa)
DperGL11075GL11075. (1033 aa)
slx1Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (291 aa)
DperGL17307GL17307. (309 aa)
DperGL17546GL17546. (1312 aa)
Fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (386 aa)
DperGL25721GL25721. (430 aa)
DperGL26094GL26094. (103 aa)
DperGL26097Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (570 aa)
DperGL26163GL26163. (408 aa)
DperGL12075GL12075; Belongs to the PI3/PI4-kinase family. (1563 aa)
DperGL12076GL12076. (801 aa)
DperGL12354Poly [ADP-ribose] polymerase. (992 aa)
DperGL12271GL12271. (578 aa)
DperGL13479DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (335 aa)
DperGL14311Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (397 aa)
DperGL25194GL25194. (216 aa)
DperGL25208GL25208. (646 aa)
DperGL25252GL25252. (326 aa)
DperGL25269GL25269. (397 aa)
DperGL24844GL24844. (507 aa)
DperGL25284GL25284. (517 aa)
DperGL26495GL26495. (511 aa)
DperGL26345GL26345; Belongs to the protein kinase superfamily. (465 aa)
DperGL14215GL14215. (419 aa)
DperGL24569GL24569. (187 aa)
DperGL24576GL24576. (485 aa)
DperGL14681GL14681. (615 aa)
DperGL21219DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1178 aa)
DperGL21139GL21139. (967 aa)
DperGL21125GL21125. (557 aa)
DperGL20619GL20619. (231 aa)
DperGL20284GL20284. (382 aa)
DperGL19863GL19863. (1431 aa)
DperGL27179DNA ligase. (788 aa)
DperGL27348GL27348; Belongs to the protein kinase superfamily. (314 aa)
DperGL27356GL27356. (386 aa)
DperGL14973GL14973. (575 aa)
DperGL22468GL22468. (754 aa)
DperGL17887GL17887. (411 aa)
DperGL17969GL17969. (236 aa)
DperGL26791Serine/threonine-protein phosphatase. (307 aa)
DperGL20814GL20814. (237 aa)
DperGL20815GL20815; Belongs to the cyclin family. (306 aa)
DperGL18220GL18220. (485 aa)
DperGL10207GL10207. (234 aa)
DperGL20217GL20217. (1243 aa)
DperGL12721GL12721. (386 aa)
DperGL12720GL12720. (408 aa)
DperGL12719GL12719. (248 aa)
DperGL20939GL20939. (1339 aa)
DperGL18385GL18385. (111 aa)
DperGL18384GL18384. (90 aa)
DperGL22420GL22420; Belongs to the ATP-dependent DNA ligase family. (916 aa)
DperGL21385Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (174 aa)
DperGL21384GL21384. (337 aa)
DperGL16334GL16334. (792 aa)
DperGL21333GL21333. (682 aa)
DperGL22221Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
DperGL22360GL22360. (946 aa)
DperGL21439GL21439. (297 aa)
DperGL18118GL18118. (117 aa)
Your Current Organism:
Drosophila persimilis
NCBI taxonomy Id: 7234
Other names: D. persimilis
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