(77 nodes) p53-Independent DNA Damage Response network (Drosophila persimilis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DperGL22394	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (246 aa)
	DperGL12443	GL12443. (209 aa)
	DperGL14290	GL14290. (202 aa)
	DperGL13989	GL13989. (128 aa)
	DperGL16040	GL16040. (205 aa)
	DperGL24711	Proteasome subunit beta. (272 aa)
	DperGL14346	GL14346. (265 aa)
	DperGL26345	GL26345; Belongs to the protein kinase superfamily. (465 aa)
	DperGL26359	GL26359. (204 aa)
	DperGL26572	Proteasome subunit beta. (210 aa)
	DperGL14524	Proteasome subunit beta. (270 aa)
	DperGL17442	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (244 aa)
	DperGL26231	GL26231. (238 aa)
	DperGL25789	Proteasome subunit beta; Belongs to the peptidase T1B family. (242 aa)
	DperGL25772	GL25772. (430 aa)
	DperGL22949	GL22949. (135 aa)
	DperGL20068	GL20068. (343 aa)
	DperGL20413	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (252 aa)
	DperGL16204	GL16204. (307 aa)
	DperGL10241	GL10241. (270 aa)
	DperGL10238	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (254 aa)
	DperGL10209	Proteasome subunit beta. (225 aa)
	DperGL10139	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (262 aa)
	DperGL15166	GL15166. (327 aa)
	DperGL13311	GL13311. (247 aa)
	DperGL23970	GL23970. (219 aa)
	DperGL24524	GL24524. (500 aa)
	DperGL24166	GL24166; Belongs to the AAA ATPase family. (417 aa)
	DperGL23337	GL23337. (389 aa)
	DperGL23259	GL23259; Belongs to the AAA ATPase family. (428 aa)
	DperGL23235	GL23235; Belongs to the AAA ATPase family. (386 aa)
	DperGL18993	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (281 aa)
	DperGL18966	GL18966. (156 aa)
	DperGL19635	Proteasome subunit beta; Belongs to the peptidase T1B family. (246 aa)
	DperGL13291	GL13291. (237 aa)
	DperGL17868	GL17868. (264 aa)
	DperGL15875	GL15875. (487 aa)
	DperGL22667	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (917 aa)
	DperGL27312	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (234 aa)
	DperGL27233	GL27233. (208 aa)
	DperGL19755	GL19755. (198 aa)
	DperGL20224	GL20224. (117 aa)
	DperGL20284	GL20284. (382 aa)
	DperGL20619	GL20619. (231 aa)
	DperGL20276	GL20276; Belongs to the AAA ATPase family. (397 aa)
	DperGL16409	GL16409; Belongs to the AAA ATPase family. (269 aa)
	DperGL24418	GL24418. (225 aa)
	DperGL26115	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (219 aa)
	DperGL26159	GL26159. (496 aa)
	DperGL19650	GL19650. (88 aa)
	DperGL19651	GL19651. (397 aa)
	DperGL19338	Proteasome subunit beta. (214 aa)
	DperGL11283	Proteasome subunit beta. (305 aa)
	DperGL11287	GL11287. (183 aa)
	DperGL11421	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (244 aa)
	DperGL10628	GL10628. (421 aa)
	DperGL21838	Proteasome subunit beta. (312 aa)
	DperGL22004	Proteasome subunit beta. (298 aa)
	DperGL22187	Proteasome subunit beta; Belongs to the peptidase T1B family. (268 aa)
	DperGL22312	GL22312. (263 aa)
	DperGL12496	Proteasome subunit beta. (205 aa)
	DperGL12054	GL12054. (61 aa)
	DperGL12053	GL12053. (181 aa)
	DperGL13667	GL13667. (488 aa)
	DperGL13666	GL13666. (520 aa)
	DperGL13830	GL13830. (382 aa)
	DperGL13601	GL13601. (238 aa)
	DperGL15090	GL15090. (263 aa)
	DperGL26475	GL26475. (308 aa)
	DperGL26311	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (277 aa)
	DperGL25194	GL25194. (216 aa)
	DperGL25072	GL25072; Belongs to the AAA ATPase family. (389 aa)
	DperGL22943	GL22943. (230 aa)
	DperGL27100	GL27100; Belongs to the AAA ATPase family. (413 aa)
	DperGL19724	Proteasome endopeptidase complex. (252 aa)
	DperGL21346	Proteasome endopeptidase complex. (185 aa)
	DperGL11890	GL11890. (391 aa)

Your Current Organism:

Drosophila persimilis

NCBI taxonomy Id: 7234
Other names: D. persimilis

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DperGL10139	DperGL10209	B4H4Z6	B4H535	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	Proteasome subunit beta.	0.981
DperGL10139	DperGL10238	B4H4Z6	B4H587	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.985
DperGL10139	DperGL10241	B4H4Z6	B4H590	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	GL10241.	0.451
DperGL10139	DperGL10628	B4H4Z6	B4GAX9	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	GL10628.	0.986
DperGL10139	DperGL11283	B4H4Z6	B4GA00	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	Proteasome subunit beta.	0.965
DperGL10139	DperGL11287	B4H4Z6	B4GA08	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	GL11287.	0.915
DperGL10139	DperGL11421	B4H4Z6	B4GAQ3	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.996
DperGL10139	DperGL11890	B4H4Z6	B4HBT7	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	GL11890.	0.991
DperGL10139	DperGL12053	B4H4Z6	B4GLD9	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	GL12053.	0.970
DperGL10139	DperGL12054	B4H4Z6	B4GLD8	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	GL12054.	0.956
DperGL10139	DperGL12443	B4H4Z6	B4HDE7	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	GL12443.	0.727
DperGL10139	DperGL12496	B4H4Z6	B4GL36	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	Proteasome subunit beta.	0.974
DperGL10139	DperGL13291	B4H4Z6	B4H307	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	GL13291.	0.915
DperGL10139	DperGL13311	B4H4Z6	B4H3A3	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	GL13311.	0.732
DperGL10139	DperGL13666	B4H4Z6	B4GP66	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	GL13666.	0.933
DperGL10139	DperGL13667	B4H4Z6	B4GP65	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	GL13667.	0.933
DperGL10139	DperGL13830	B4H4Z6	B4GP78	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	GL13830.	0.972
DperGL10139	DperGL13989	B4H4Z6	B4GQQ7	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	GL13989.	0.908
DperGL10139	DperGL14290	B4H4Z6	B4GQG1	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	GL14290.	0.732
DperGL10139	DperGL14346	B4H4Z6	B4GTG5	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	GL14346.	0.985