(100 nodes) Ubiquitin mediated proteolysis network (Drosophila persimilis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DperGL23929	GL23929. (282 aa)
	DperGL23564	GL23564. (700 aa)
	DperGL24447	GL24447; Belongs to the ubiquitin-conjugating enzyme family. (167 aa)
	DperGL23355	GL23355. (662 aa)
	DperGL23281	GL23281; Belongs to the cullin family. (846 aa)
	DperGL24391	GL24391. (1140 aa)
	DperGL23835	GL23835. (4950 aa)
	DperGL23670	GL23670; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	DperGL19021	GL19021. (551 aa)
	DperGL19010	GL19010. (289 aa)
	DperGL18966	GL18966. (156 aa)
	DperGL19258	GL19258; Belongs to the ubiquitin-conjugating enzyme family. (159 aa)
	DperGL11352	GL11352. (517 aa)
	DperGL10672	GL10672. (113 aa)
	DperGL10659	Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (195 aa)
	DperGL10569	GL10569. (102 aa)
	DperGL11645	GL11645; Belongs to the cullin family. (802 aa)
	DperGL11182	GL11182. (640 aa)
	DperGL11695	GL11695; Belongs to the cullin family. (774 aa)
	DperGL21922	GL21922. (745 aa)
	DperGL21949	GL21949. (1278 aa)
	DperGL22031	GL22031. (507 aa)
	DperGL22213	GL22213; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	DperGL22220	GL22220. (2701 aa)
	DperGL21579	GL21579. (192 aa)
	DperGL17305	GL17305. (154 aa)
	DperGL17328	GL17328; Belongs to the ubiquitin-activating E1 family. (627 aa)
	DperGL17383	GL17383; Belongs to the cullin family. (816 aa)
	DperGL17480	GL17480. (450 aa)
	DperGL16990	GL16990; Belongs to the SKP1 family. (162 aa)
	DperGL17560	GL17560; Belongs to the SKP1 family. (169 aa)
	DperGL17622	GL17622. (660 aa)
	DperGL16786	GL16786. (367 aa)
	DperGL17723	GL17723. (188 aa)
	DperGL16726	GL16726; Belongs to the SKP1 family. (117 aa)
	DperGL17270	GL17270; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
	DperGL17271	GL17271. (80 aa)
	DperGL16701	GL16701. (505 aa)
	DperGL25585	GL25585. (996 aa)
	DperGL25796	GL25796; Belongs to the cullin family. (756 aa)
	DperGL12326	GL12326. (533 aa)
	DperGL12289	GL12289; Belongs to the ubiquitin-conjugating enzyme family. (170 aa)
	DperGL12172	GL12172; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
	DperGL13928	GL13928. (118 aa)
	DperGL14050	GL14050. (482 aa)
	DperGL13836	GL13836. (1404 aa)
	DperGL14565	GL14565. (283 aa)
	DperGL15781	GL15781. (284 aa)
	DperGL16225	GL16225. (290 aa)
	DperGL16343	GL16343. (532 aa)
	DperGL13989	GL13989. (128 aa)
	DperGL25100	GL25100. (243 aa)
	DperGL25195	GL25195; Belongs to the ubiquitin-conjugating enzyme family. (176 aa)
	DperGL24900	GL24900. (932 aa)
	DperGL26600	GL26600; Belongs to the cullin family. (1008 aa)
	DperGL26609	GL26609. (681 aa)
	DperGL26387	GL26387; Belongs to the ubiquitin-conjugating enzyme family. (228 aa)
	DperGL25212	GL25212. (86 aa)
	DperGL25518	GL25518; Belongs to the ubiquitin-conjugating enzyme family. (259 aa)
	DperGL12870	GL12870; Belongs to the SKP1 family. (175 aa)
	DperGL12977	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (769 aa)
	DperGL14737	GL14737. (1997 aa)
	DperGL14550	GL14550. (472 aa)
	DperGL20284	GL20284. (382 aa)
	DperGL20231	GL20231. (194 aa)
	DperGL20230	GL20230. (178 aa)
	DperGL20227	GL20227. (125 aa)
	DperGL27281	GL27281. (381 aa)
	DperGL27174	GL27174. (340 aa)
	DperGL14825	GL14825; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
	DperGL22563	GL22563; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	DperGL22584	GL22584. (123 aa)
	DperGL22481	SUMO-activating enzyme subunit; Belongs to the ubiquitin-activating E1 family. (687 aa)
	DperGL26839	GL26839. (3840 aa)
	DperGL26777	GL26777. (211 aa)
	DperGL26898	GL26898; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	DperGL13359	GL13358; Belongs to the SKP1 family. (162 aa)
	DperGL13357	GL13357. (108 aa)
	DperGL13341	GL13341. (604 aa)
	DperGL13385	GL13385. (390 aa)
	DperGL11784	GL11784. (202 aa)
	DperGL20714	GL20714. (140 aa)
	DperGL20852	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (314 aa)
	DperGL20853	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (340 aa)
	DperGL18350	GL18350; Belongs to the ubiquitin-conjugating enzyme family. (167 aa)
	DperGL16177	GL16177. (1052 aa)
	DperGL16057	GL16057. (758 aa)
	DperGL24602	GL24602. (367 aa)
	DperGL19994	GL19994. (1124 aa)
	DperGL12727	GL12727. (1406 aa)
	DperGL12716	GL12716; Belongs to the ubiquitin-conjugating enzyme family. (199 aa)
	DperGL24781	GL24781. (1195 aa)
	GL16001	Ubiquitin-conjugating enzyme E2 S; Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme vih/UbcH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. (209 aa)
	DperGL15031	GL15031. (1083 aa)
	DperGL16260	GL16260. (493 aa)
	DperGL11881	GL11881. (742 aa)
	DperGL11879	GL11879. (1027 aa)
	DperGL18094	GL18094; Belongs to the SKP1 family. (151 aa)
	DperGL18093	GL18093; Belongs to the SKP1 family. (148 aa)
	DperGL15335	GL15335; Belongs to the SKP1 family. (162 aa)

Your Current Organism:

Drosophila persimilis

NCBI taxonomy Id: 7234
Other names: D. persimilis

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DperGL10569	DperGL10672	B4GB82	B4GAP5	GL10569.	GL10672.	0.543
DperGL10569	DperGL11695	B4GB82	B4GD46	GL10569.	GL11695; Belongs to the cullin family.	0.984
DperGL10569	DperGL12172	B4GB82	B4GMT8	GL10569.	GL12172; Belongs to the ubiquitin-conjugating enzyme family.	0.444
DperGL10569	DperGL12289	B4GB82	B4GMA1	GL10569.	GL12289; Belongs to the ubiquitin-conjugating enzyme family.	0.587
DperGL10569	DperGL12326	B4GB82	B4GM49	GL10569.	GL12326.	0.897
DperGL10569	DperGL12727	B4GB82	B4H7X4	GL10569.	GL12727.	0.806
DperGL10569	DperGL12870	B4GB82	B4GVB7	GL10569.	GL12870; Belongs to the SKP1 family.	0.893
DperGL10569	DperGL13357	B4GB82	B4H311	GL10569.	GL13357.	0.904
DperGL10569	DperGL13359	B4GB82	B4H308	GL10569.	GL13358; Belongs to the SKP1 family.	0.893
DperGL10569	DperGL13928	B4GB82	B4GN18	GL10569.	GL13928.	0.907
DperGL10569	DperGL13989	B4GB82	B4GQQ7	GL10569.	GL13989.	0.800
DperGL10569	DperGL14825	B4GB82	B4H0K9	GL10569.	GL14825; Belongs to the ubiquitin-conjugating enzyme family.	0.603
DperGL10569	DperGL15335	B4GB82	B4IR53	GL10569.	GL15335; Belongs to the SKP1 family.	0.893
DperGL10569	DperGL16726	B4GB82	B4GIM9	GL10569.	GL16726; Belongs to the SKP1 family.	0.897
DperGL10569	DperGL16990	B4GB82	B4GH87	GL10569.	GL16990; Belongs to the SKP1 family.	0.893
DperGL10569	DperGL17270	B4GB82	B4GIV0	GL10569.	GL17270; Belongs to the ubiquitin-conjugating enzyme family.	0.444
DperGL10569	DperGL17383	B4GB82	B4GGN9	GL10569.	GL17383; Belongs to the cullin family.	0.893
DperGL10569	DperGL17480	B4GB82	B4GH83	GL10569.	GL17480.	0.654
DperGL10569	DperGL17560	B4GB82	B4GHN1	GL10569.	GL17560; Belongs to the SKP1 family.	0.893
DperGL10569	DperGL17622	B4GB82	B4GHZ5	GL10569.	GL17622.	0.418