(15 nodes) Mixed, incl. NuRD complex, and Histone deacetylase family network (Drosophila sechellia)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsecGM25223	GM25223. (867 aa)
	DsecGM26582	GM26582. (477 aa)
	DsecGM23455	GM23455. (343 aa)
	DsecGM23815	GM23815. (338 aa)
	DsecGM12057	GM12057. (150 aa)
	DsecGM10605	GM10605. (880 aa)
	DsecGM22965	GM22965. (664 aa)
	DsecGM22263	Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. (888 aa)
	DsecGM11459	GM11459. (281 aa)
	DsecGM11462	GM11462. (602 aa)
	DsecGM19418	GM19418. (882 aa)
	DsecGM15785	GM15785. (1921 aa)
	DsecGM15108	GM15108. (549 aa)
	DsecGM19975	GM19975. (479 aa)
	DsecGM20078	GM20078. (619 aa)

Your Current Organism:

Drosophila sechellia

NCBI taxonomy Id: 7238
Other names: D. sechellia

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DsecGM10605	DsecGM11459	B4I449	B4IDY3	GM10605.	GM11459.	0.818
DsecGM10605	DsecGM11462	B4I449	B4IDY9	GM10605.	GM11462.	0.851
DsecGM10605	DsecGM12057	B4I449	B4HWE6	GM10605.	GM12057.	0.552
DsecGM10605	DsecGM15785	B4I449	B4IIS0	GM10605.	GM15785.	0.982
DsecGM10605	DsecGM19418	B4I449	B4IIK5	GM10605.	GM19418.	0.948
DsecGM10605	DsecGM19975	B4I449	B4ILG2	GM10605.	GM19975.	0.870
DsecGM10605	DsecGM20078	B4I449	B4ILG3	GM10605.	GM20078.	0.870
DsecGM10605	DsecGM22263	B4I449	B4IA61	GM10605.	Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3.	0.753
DsecGM10605	DsecGM22965	B4I449	B4I762	GM10605.	GM22965.	0.625
DsecGM10605	DsecGM23455	B4I449	B4HHL9	GM10605.	GM23455.	0.722
DsecGM10605	DsecGM23815	B4I449	B4HJY2	GM10605.	GM23815.	0.999
DsecGM10605	DsecGM25223	B4I449	B4HDR0	GM10605.	GM25223.	0.979
DsecGM10605	DsecGM26582	B4I449	B4HGL4	GM10605.	GM26582.	0.627
DsecGM11459	DsecGM10605	B4IDY3	B4I449	GM11459.	GM10605.	0.818
DsecGM11459	DsecGM11462	B4IDY3	B4IDY9	GM11459.	GM11462.	0.497
DsecGM11459	DsecGM15785	B4IDY3	B4IIS0	GM11459.	GM15785.	0.719
DsecGM11459	DsecGM19418	B4IDY3	B4IIK5	GM11459.	GM19418.	0.863
DsecGM11459	DsecGM23815	B4IDY3	B4HJY2	GM11459.	GM23815.	0.926
DsecGM11459	DsecGM25223	B4IDY3	B4HDR0	GM11459.	GM25223.	0.806
DsecGM11462	DsecGM10605	B4IDY9	B4I449	GM11462.	GM10605.	0.851