(58 nodes) Positive regulation of autophagy network (Drosophila sechellia)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsecGM25729	GM25729. (279 aa)
	DsecGM25819	GM25819; Belongs to the cyclin family. (267 aa)
	DsecGM23598	GM23598. (489 aa)
	DsecGM24629	GM24629. (785 aa)
	DsecGM26560	GM26560. (1100 aa)
	DsecGM24565	GM24565. (610 aa)
	DsecGM26070	GM26070. (1972 aa)
	DsecGM24949	GM24949. (652 aa)
	DsecGM26268	GM26268. (520 aa)
	DsecGM25133	GM25133. (82 aa)
	DsecGM24836	GM24836; Belongs to the protein kinase superfamily. (446 aa)
	DsecGM21300	GM21300. (299 aa)
	DsecGM19894	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. (684 aa)
	DsecGM21984	GM21984; Belongs to the Toll-like receptor family. (1444 aa)
	DsecGM21990	GM21990; Belongs to the Toll-like receptor family. (1387 aa)
	DsecGM20882	GM20882. (302 aa)
	DsecGM20208	GM20208. (1455 aa)
	DsecGM20999	GM20999; Belongs to the WD repeat SEC13 family. (354 aa)
	DsecGM21157	GM21157. (316 aa)
	DsecGM21158	GM21158. (220 aa)
	DsecGM14039	GM14039. (323 aa)
	DsecGM14658	GM14658. (387 aa)
	DsecGM13894	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (490 aa)
	DsecGM14207	GM14207. (1543 aa)
	DsecGM11912	Mitogen-activated protein kinase. (372 aa)
	DsecGM11868	GM11868. (1136 aa)
	DsecGM12734	GM12734. (3582 aa)
	DsecGM12747	GM12747. (2050 aa)
	DsecGM12225	GM12225. (777 aa)
	DsecGM12862	GM12862. (1276 aa)
	DsecGM12863	GM12863. (213 aa)
	DsecGM12129	GM12129. (1096 aa)
	DsecGM12559	GM12559. (144 aa)
	DsecGM12519	GM12519. (78 aa)
	DsecGM12560	GM11668. (112 aa)
	DsecGM12513	GM12513. (701 aa)
	DsecGM17877	GM17877. (419 aa)
	DsecGM18321	GM18321. (867 aa)
	DsecGM10634	GM10634. (1164 aa)
	DsecGM22987	GM22987. (234 aa)
	DsecGM22988	GM22988. (233 aa)
	DsecGM16025	GM16025; Belongs to the peptidase C14A family. (323 aa)
	DsecGM16042	GM16042. (484 aa)
	DsecGM19132	Non-specific serine/threonine protein kinase. (565 aa)
	DsecGM22256	GM22256. (1851 aa)
	DsecGM22162	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (468 aa)
	DsecGM10163	GM10163. (911 aa)
	DsecGM10383	GM10383. (135 aa)
	DsecGM16671	AP-2 complex subunit alpha; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. (940 aa)
	DsecGM13358	GM13358. (412 aa)
	DsecGM13439	GM13439. (460 aa)
	DsecGM14948	GM14948. (410 aa)
	DsecGM11518	GM11518. (1180 aa)
	DsecGM22522	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1678 aa)
	DsecGM22595	GM22595; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (712 aa)
	DsecGM10050	GM10050. (224 aa)
	DsecGM13030	GM13030. (730 aa)
	DsecGM11204	GM11204. (468 aa)

Your Current Organism:

Drosophila sechellia

NCBI taxonomy Id: 7238
Other names: D. sechellia

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DsecGM10050	DsecGM26070	B4IKP8	B4HHX0	GM10050.	GM26070.	0.720
DsecGM10163	DsecGM16671	B4IBZ6	B4ICW5	GM10163.	AP-2 complex subunit alpha; Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles.	0.660
DsecGM10163	DsecGM22522	B4IBZ6	B4IKE0	GM10163.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.627
DsecGM10163	DsecGM22595	B4IBZ6	B4IKF6	GM10163.	GM22595; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.423
DsecGM11204	DsecGM11518	B4IKY0	B4IGL9	GM11204.	GM11518.	0.527
DsecGM11204	DsecGM11912	B4IKY0	B4HWI3	GM11204.	Mitogen-activated protein kinase.	0.406
DsecGM11204	DsecGM12513	B4IKY0	B4I079	GM11204.	GM12513.	0.626
DsecGM11204	DsecGM13439	B4IKY0	B4IF77	GM11204.	GM13439.	0.988
DsecGM11204	DsecGM16025	B4IKY0	B4I8P7	GM11204.	GM16025; Belongs to the peptidase C14A family.	0.756
DsecGM11204	DsecGM19894	B4IKY0	B4HNY7	GM11204.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.	0.514
DsecGM11204	DsecGM20882	B4IKY0	B4HPW0	GM11204.	GM20882.	0.620
DsecGM11204	DsecGM21984	B4IKY0	B4HPS5	GM11204.	GM21984; Belongs to the Toll-like receptor family.	0.495
DsecGM11204	DsecGM21990	B4IKY0	B4HPT7	GM11204.	GM21990; Belongs to the Toll-like receptor family.	0.464
DsecGM11204	DsecGM24629	B4IKY0	B4HG64	GM11204.	GM24629.	0.410
DsecGM11518	DsecGM11204	B4IGL9	B4IKY0	GM11518.	GM11204.	0.527
DsecGM11518	DsecGM11912	B4IGL9	B4HWI3	GM11518.	Mitogen-activated protein kinase.	0.999
DsecGM11912	DsecGM11204	B4HWI3	B4IKY0	Mitogen-activated protein kinase.	GM11204.	0.406
DsecGM11912	DsecGM11518	B4HWI3	B4IGL9	Mitogen-activated protein kinase.	GM11518.	0.999
DsecGM12225	DsecGM13358	B4HZE0	B4IEU6	GM12225.	GM13358.	0.999
DsecGM12225	DsecGM13894	B4HZE0	B4HUJ3	GM12225.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.426