(209 nodes) Apical part of cell network (Drosophila sechellia)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsecGM13523	GM13523. (1556 aa)
	DsecGM13521	GM13521. (337 aa)
	DsecGM13300	GM13300. (1370 aa)
	DsecGM13322	GM13322. (641 aa)
	DsecGM13492	GM13492. (589 aa)
	DsecGM13385	GM13385. (990 aa)
	DsecGM25965	GM25965. (880 aa)
	DsecGM11477	GM11477. (403 aa)
	DsecGM11474	GM11474. (601 aa)
	DsecGM11365	GM11365. (128 aa)
	DsecGM11364	GM11364. (1676 aa)
	DsecGM11366	GM11366. (2360 aa)
	DsecGM16744	GM16744. (1425 aa)
	DsecGM16681	GM16681. (502 aa)
	DsecGM10317	GM10317. (789 aa)
	DsecGM10127	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1410 aa)
	DsecGM10351	GM10351. (419 aa)
	DsecGM15144	GM15144. (494 aa)
	DsecGM15386	GM15386. (2541 aa)
	DsecGM15226	GM15226. (326 aa)
	DsecGM22073	GM22073; Belongs to the small GTPase superfamily. Arf family. (182 aa)
	DsecGM22291	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (527 aa)
	DsecGM22290	GM22290. (612 aa)
	DsecGM22250	GM22250. (404 aa)
	DsecGM19264	GM19264. (2671 aa)
	DsecGM23596	GM23596. (601 aa)
	DsecGM26478	GM26478. (451 aa)
	DsecGM23631	GM23631. (758 aa)
	DsecGM23632	GM23632. (1175 aa)
	Kibra	Protein kibra; Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signalin [...] (1295 aa)
	DsecGM25825	GM25825. (2646 aa)
	DsecGM25824	GM25824. (952 aa)
	DsecGM25822	GM25822. (212 aa)
	DsecGM24222	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1291 aa)
	DsecGM19263	GM19263. (807 aa)
	DsecGM25546	GM25546. (602 aa)
	DsecGM23939	GM23939. (1765 aa)
	DsecGM23956	GM23956. (363 aa)
	DsecGM26069	Chloride channel protein. (1283 aa)
	DsecGM24547	GM24547. (940 aa)
	DsecGM23443	GM23443. (1185 aa)
	DsecGM26632	GM26632. (74 aa)
	DsecGM26631	GM26631. (80 aa)
	DsecGM25461	GM25461. (526 aa)
	DsecGM26586	GM26586. (2292 aa)
	DsecGM26568	GM26568. (1067 aa)
	DsecGM25951	GM20676. (137 aa)
	DsecGM24670	GM24670. (1029 aa)
	DsecGM24683	GM24683. (1903 aa)
	DsecGM14395	GM14395. (696 aa)
	DsecGM14406	GM14406; Belongs to the peptidase S54 family. (344 aa)
	Dsecve	Ve; Belongs to the peptidase S54 family. (364 aa)
	DsecGM14169	GM14169. (2447 aa)
	DsecGM14448	GM14448. (304 aa)
	DsecGM14449	GM14449. (548 aa)
	DsecGM11746	GM11746. (598 aa)
	DsecGM18775	GM18775. (596 aa)
	DsecGM18896	GM18896. (816 aa)
	DsecGM11060	GM11060. (1875 aa)
	DsecGM14511	GM14511. (571 aa)
	DsecGM13662	GM13662. (1274 aa)
	DsecGM13664	GM13664. (1956 aa)
	DsecGM13177	GM13177. (1762 aa)
	DsecGM13100	Tyrosine-protein kinase. (785 aa)
	DsecGM12733	GM12733. (808 aa)
	DsecGM12280	GM12280. (2420 aa)
	DsecGM12273	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (517 aa)
	DsecGM12830	GM12830. (352 aa)
	DsecGM12831	GM12831. (1347 aa)
	DsecGM12129	GM12129. (1096 aa)
	DsecGM12908	GM12908. (774 aa)
	DsecGM12091	GM12091; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (526 aa)
	DsecGM12587	Spaghetti squash. (174 aa)
	DsecGM12462	GM12462. (954 aa)
	DsecGM12377	GM12377. (1679 aa)
	DsecGM12701	GM12701. (888 aa)
	DsecGM18529	GM18529. (325 aa)
	DsecGM18569	GM18569. (447 aa)
	DsecGM18620	GM18620. (1545 aa)
	DsecGM17951	GM17951. (1200 aa)
	DsecGM18655	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2549 aa)
	DsecGM18466	GM18466. (520 aa)
	DsecGM10642	GM10642. (1816 aa)
	DsecGM10592	GM10592. (985 aa)
	DsecGM10939	GM10939. (1682 aa)
	DsecGM10947	GM10947. (470 aa)
	DsecGM17330	GM17330. (1034 aa)
	DsecGM22691	GM22691. (201 aa)
	DsecGM22856	GM22856. (132 aa)
	DsecGM22824	GM22824. (401 aa)
	DsecGM22718	GM22718. (1256 aa)
	DsecGM22716	GM22716. (635 aa)
	DsecGM14312	GM14312. (397 aa)
	DsecGM13800	GM13800. (355 aa)
	DsecGM13883	GM13883. (418 aa)
	DsecGM14680	GM14680. (1114 aa)
	DsecGM14679	GM14679. (735 aa)
	DsecGM13985	GM13985. (611 aa)
	DsecGM14013	GM14013. (1152 aa)
	DsecGM14052	GM14052. (588 aa)
	DsecGM14568	GM14568. (4319 aa)
	DsecGM14558	GM14558. (445 aa)
	DsecGM13616	GM13616. (69 aa)
	DsecGM23562	GM23562. (127 aa)
	DsecGM26703	GM26703. (138 aa)
	DsecGM13270	GM13270. (509 aa)
	DsecGM11116	GM11116. (715 aa)
	DsecGM22983	GM22983. (154 aa)
	DsecGM15774	GM15774. (859 aa)
	DsecGM15798	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
	DsecGM15842	Receptor protein-tyrosine kinase. (1425 aa)
	DsecGM15888	GM15888. (1324 aa)
	DsecGM15612	GM15612. (1401 aa)
	DsecGM14085	GM14085. (1013 aa)
	DsecGM15611	GM15611. (1530 aa)
	DsecGM15524	GM15524; Belongs to the MIP/aquaporin (TC 1.A.8) family. (265 aa)
	DsecGM15522	GM15522; Belongs to the MIP/aquaporin (TC 1.A.8) family. (261 aa)
	DsecGM19085	GM19085. (1249 aa)
	DsecGM19086	GM19086. (425 aa)
	DsecGM18941	GM18941. (539 aa)
	DsecGM18939	GM18939. (170 aa)
	DsecGM18903	GM18903. (976 aa)
	DsecGM18845	GM18845. (764 aa)
	DsecGM14116	GM14116. (2308 aa)
	DsecGM21120	GM21120. (350 aa)
	DsecGM20603	GM20603. (372 aa)
	DsecGM20615	GM20615. (1534 aa)
	DsecGM21657	GM21657. (192 aa)
	DsecGM20121	GM20121. (1961 aa)
	DsecGM20643	GM20643. (421 aa)
	DsecGM20644	GM20644; Belongs to the peptidase S1 family. (250 aa)
	DsecGM21069	GM21069. (1454 aa)
	DsecGM21600	GM21600; Belongs to the integrin alpha chain family. (1115 aa)
	DsecGM21599	GM21599. (81 aa)
	DsecGM21588	GM21588. (1235 aa)
	DsecGM20163	GM20163. (131 aa)
	DsecGM20164	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (954 aa)
	DsecGM20723	GM20723. (700 aa)
	DsecGM20724	GM20724. (309 aa)
	DsecGM21007	GM21007. (758 aa)
	DsecGM21532	GM21532. (510 aa)
	DsecGM21531	GM21531. (113 aa)
	DsecGM21528	GM21528. (911 aa)
	DsecGM20777	GM20777. (180 aa)
	DsecGM20856	GM20856. (291 aa)
	DsecGM20857	GM20857. (350 aa)
	DsecGM20344	GM20344. (290 aa)
	DsecGM19825	GM19825. (668 aa)
	DsecGM21926	GM21926. (780 aa)
	DsecGM19888	GM19888. (121 aa)
	DsecGM19889	GM19889. (441 aa)
	DsecGM21319	GM21319. (515 aa)
	DsecGM20400	GM20400. (431 aa)
	DsecGM21309	GM21309. (855 aa)
	DsecGM21291	GM21291; Belongs to the MIP/aquaporin (TC 1.A.8) family. (264 aa)
	DsecGM20426	GM20426; Belongs to the MIP/aquaporin (TC 1.A.8) family. (245 aa)
	DsecGM19927	GM19927. (1035 aa)
	DsecGM21814	GM21814. (355 aa)
	DsecGM21230	GM21230; Belongs to the G-protein coupled receptor 2 family. (3575 aa)
	DsecGM19986	GM19986. (1551 aa)
	DsecGM21769	GM21769. (296 aa)
	DsecGM21749	GM21749. (696 aa)
	DsecGM21748	GM21748. (861 aa)
	DsecGM24270	GM24270. (772 aa)
	DsecGM24851	GM24851. (3444 aa)
	DsecGM26299	GM26299; Belongs to the MAGUK family. (2532 aa)
	DsecGM24305	Battenin. (368 aa)
	DsecGM24339	GM24339. (1767 aa)
	DsecGM24888	GM24888. (599 aa)
	DsecGM23791	GM23791. (320 aa)
	DsecGM25098	GM25098; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (625 aa)
	DsecGM24379	GM24379. (1617 aa)
	DsecGM25580	GM25580. (1147 aa)
	DsecGM23895	GM23895. (261 aa)
	DsecGM24452	GM24452. (1205 aa)
	DsecGM23341	GM23341. (1223 aa)
	DsecGM13236	GM13236. (1472 aa)
	DsecGM13240	GM13240. (826 aa)
	DsecGM11239	GM11239. (1309 aa)
	DsecGM11237	GM11237. (450 aa)
	DsecGM15109	GM15109. (596 aa)
	DsecGM13107	GM13107. (664 aa)
	DsecGM13099	GM13099. (1977 aa)
	DsecGM13076	GM13076. (140 aa)
	DsecGM13075	GM13075. (315 aa)
	DsecGM13074	GM13074. (178 aa)
	DsecGM21724	GM21724. (1479 aa)
	DsecGM21268	GM21268. (1168 aa)
	DsecGM13695	GM13695. (661 aa)
	DsecGM17743	GM17743; Belongs to the protein kinase superfamily. Tyr protein kinase family. (773 aa)
	DsecGM17767	GM17767. (186 aa)
	DsecGM19690	GM19690. (462 aa)
	DsecGM16160	GM16160. (246 aa)
	DsecGM23187	Signal transducer and activator of transcription. (754 aa)
	DsecGM26915	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (834 aa)
	DsecGM26878	GM26878. (800 aa)
	DsecGM17498	Innexin; Structural component of the gap junctions. Belongs to the pannexin family. (367 aa)
	DsecGM16343	GM16343. (658 aa)
	DsecGM11503	GM11503. (527 aa)
	DsecGM17668	GM17668. (667 aa)
	DsecGM17667	GM17667. (359 aa)
	DsecGM17582	GM17582. (718 aa)
	DsecGM17583	GM17583. (261 aa)
	DsecGM14926	GM14926. (203 aa)
	DsecGM23277	GM23277. (1100 aa)
	DsecGM23392	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (1289 aa)
	DsecGM23367	GM23367. (454 aa)
	DsecGM23346	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (301 aa)
	DsecGM13386	GM13386. (337 aa)

Your Current Organism:

Drosophila sechellia

NCBI taxonomy Id: 7238
Other names: D. sechellia

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DsecGM10127	DsecGM11474	B4IC56	B4IE13	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GM11474.	0.423
DsecGM10127	DsecGM15842	B4IC56	B4I7R8	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Receptor protein-tyrosine kinase.	0.522
DsecGM10127	DsecGM19264	B4IC56	B4IA25	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GM19264.	0.999
DsecGM10127	DsecGM22291	B4IC56	B4IAA8	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.580
DsecGM10127	DsecGM24452	B4IC56	B4HIM6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GM24452.	0.713
DsecGM10127	DsecGM26915	B4IC56	B4IHW6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.698
DsecGM10317	DsecGM11116	B4ICL0	B4IM31	GM10317.	GM11116.	0.426
DsecGM10317	DsecGM12733	B4ICL0	B4HZ08	GM10317.	GM12733.	0.506
DsecGM10592	DsecGM21657	B4I471	B4HSJ6	GM10592.	GM21657.	0.548
DsecGM10592	DsecGM21926	B4I471	B4HP39	GM10592.	GM21926.	0.467
DsecGM10592	DsecGM22983	B4I471	B4I7A4	GM10592.	GM22983.	0.617
DsecGM10642	DsecGM11060	B4I3Z3	B4HX55	GM10642.	GM11060.	0.426
DsecGM10642	DsecGM20400	B4I3Z3	B4HNV2	GM10642.	GM20400.	0.451
DsecGM10939	DsecGM13099	B4I4Q2	B4IK45	GM10939.	GM13099.	0.675
DsecGM10947	DsecGM12908	B4I4R8	B4HZV9	GM10947.	GM12908.	0.632
DsecGM10947	DsecGM15842	B4I4R8	B4I7R8	GM10947.	Receptor protein-tyrosine kinase.	0.621
DsecGM11060	DsecGM10642	B4HX55	B4I3Z3	GM11060.	GM10642.	0.426
DsecGM11060	DsecGM11237	B4HX55	B4IKY8	GM11060.	GM11237.	0.679
DsecGM11060	DsecGM11239	B4HX55	B4IKZ0	GM11060.	GM11239.	0.682
DsecGM11060	DsecGM13521	B4HX55	B4IF40	GM11060.	GM13521.	0.983