(43 nodes) R8 cell differentiation network (Drosophila sechellia)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsecGM12998	GM12998; Belongs to the 14-3-3 family. (138 aa)
	Kibra	Protein kibra; Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signalin [...] (1295 aa)
	DsecGM25839	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (516 aa)
	DsecGM23596	GM23596. (601 aa)
	DsecGM25020	GM25020. (1049 aa)
	DsecGM26299	GM26299; Belongs to the MAGUK family. (2532 aa)
	DsecGM23715	GM23715. (312 aa)
	DsecGM21186	GM21186; Belongs to the 14-3-3 family. (248 aa)
	DsecGM19825	GM19825. (668 aa)
	DsecGM20307	GM20307. (878 aa)
	DsecGM21084	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (617 aa)
	DsecGM13892	GM13892. (615 aa)
	DsecGM14823	GM14823. (986 aa)
	Dsecve	Ve; Belongs to the peptidase S54 family. (364 aa)
	DsecGM11080	GM11080. (685 aa)
	DsecGM11073	GM11073. (649 aa)
	DsecGM16609	Serine/threonine-protein phosphatase. (309 aa)
	DsecGM16687	GM16687. (749 aa)
	DsecGM12129	GM12129. (1096 aa)
	DsecGM18031	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (563 aa)
	DsecGM17951	GM17951. (1200 aa)
	DsecGM18275	GM18275. (391 aa)
	DsecGM18343	GM18343. (583 aa)
	DsecGM18367	GM18367. (586 aa)
	DsecGM18164	Mothers against decapentaplegic homolog. (545 aa)
	DsecGM17111	GM17111; Cadherins are calcium-dependent cell adhesion proteins. (3151 aa)
	DsecGM17110	GM17110; Cadherins are calcium-dependent cell adhesion proteins. (2044 aa)
	DsecGM22866	GM22866; Belongs to the AAA ATPase family. (442 aa)
	DsecGM22735	GM22735. (357 aa)
	DsecGM22733	GM22733. (106 aa)
	DsecGM22734	GM22734. (171 aa)
	DsecGM22716	GM22716. (635 aa)
	DsecGM15842	Receptor protein-tyrosine kinase. (1425 aa)
	DsecGM16052	GM16052. (455 aa)
	DsecGM15292	GM15292; Belongs to the 14-3-3 family. (262 aa)
	DsecGM10171	GM10171; Belongs to the peptidase S8 family. (654 aa)
	DsecGM16707	GM16707. (1161 aa)
	DsecGM16849	E3 ubiquitin-protein ligase. (949 aa)
	DsecGM13432	GM13432. (710 aa)
	DsecGM13433	GM13433. (699 aa)
	DsecGM26771	GM26771. (598 aa)
	DsecGM13010	GM13010. (948 aa)
	DsecGM11208	Mothers against decapentaplegic homolog. (486 aa)

Your Current Organism:

Drosophila sechellia

NCBI taxonomy Id: 7238
Other names: D. sechellia

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DsecGM10171	DsecGM13433	B4ICP4	B4IF69	GM10171; Belongs to the peptidase S8 family.	GM13433.	0.900
DsecGM11073	DsecGM11080	B4HX49	B4HX48	GM11073.	GM11080.	0.917
DsecGM11073	DsecGM18343	B4HX49	B4I2K9	GM11073.	GM18343.	0.505
DsecGM11080	DsecGM11073	B4HX48	B4HX49	GM11080.	GM11073.	0.917
DsecGM11080	DsecGM18343	B4HX48	B4I2K9	GM11080.	GM18343.	0.505
DsecGM11208	DsecGM13010	B4IKX2	B4IKR2	Mothers against decapentaplegic homolog.	GM13010.	0.836
DsecGM11208	DsecGM13432	B4IKX2	B4IF68	Mothers against decapentaplegic homolog.	GM13432.	0.417
DsecGM11208	DsecGM13433	B4IKX2	B4IF69	Mothers against decapentaplegic homolog.	GM13433.	0.417
DsecGM11208	DsecGM15842	B4IKX2	B4I7R8	Mothers against decapentaplegic homolog.	Receptor protein-tyrosine kinase.	0.580
DsecGM11208	DsecGM16052	B4IKX2	B4I8U4	Mothers against decapentaplegic homolog.	GM16052.	0.593
DsecGM11208	DsecGM16849	B4IKX2	B4IDF3	Mothers against decapentaplegic homolog.	E3 ubiquitin-protein ligase.	0.556
DsecGM11208	DsecGM18031	B4IKX2	B4I1E4	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.800
DsecGM11208	DsecGM18275	B4IKX2	B4I2C6	Mothers against decapentaplegic homolog.	GM18275.	0.710
DsecGM11208	DsecGM18343	B4IKX2	B4I2K9	Mothers against decapentaplegic homolog.	GM18343.	0.799
DsecGM11208	DsecGM18367	B4IKX2	B4I2Q6	Mothers against decapentaplegic homolog.	GM18367.	0.621
DsecGM11208	DsecGM21084	B4IKX2	B4HSC7	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.993
DsecGM11208	DsecGM25839	B4IKX2	B4HEL0	Mothers against decapentaplegic homolog.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.861
DsecGM11208	DsecGM26771	B4IKX2	B4IIY4	Mothers against decapentaplegic homolog.	GM26771.	0.755
DsecGM11208	Kibra	B4IKX2	B4HEJ6	Mothers against decapentaplegic homolog.	Protein kibra; Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signalin [...]	0.515
DsecGM12129	DsecGM12998	B4HZV7	B4INF8	GM12129.	GM12998; Belongs to the 14-3-3 family.	0.536