(20 nodes) Sevenless signaling pathway network (Drosophila sechellia)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsecGM11266	GM11266. (2565 aa)
	Dsecpnt	Pnt. (627 aa)
	DsecGM23574	GM23574. (243 aa)
	DsecGM25664	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (314 aa)
	Ras85D	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa)
	DsecGM19986	GM19986. (1551 aa)
	DsecGM20273	GM20273. (211 aa)
	DsecGM20209	GM20209. (404 aa)
	DsecGM14496	GM14496. (876 aa)
	DsecGM15254	GM15254. (1580 aa)
	DsecGM10629	GM10629. (959 aa)
	DsecGM19196	GM19196. (122 aa)
	DsecGM19198	GM19198. (939 aa)
	DsecGM19224	GM19224. (739 aa)
	DsecGM16442	GM16442. (643 aa)
	DsecGM16443	GM16443. (530 aa)
	DsecGM22414	GM22414; Belongs to the protein kinase superfamily. (396 aa)
	DsecGM16932	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (340 aa)
	DsecGM23674	GM23674. (736 aa)
	DsecGM15025	GM15025. (219 aa)

Your Current Organism:

Drosophila sechellia

NCBI taxonomy Id: 7238
Other names: D. sechellia

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DsecGM10629	DsecGM15254	B4I411	B4HXA0	GM10629.	GM15254.	0.454
DsecGM10629	DsecGM16932	B4I411	B4ILW5	GM10629.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.561
DsecGM10629	DsecGM19196	B4I411	B4I9P1	GM10629.	GM19196.	0.597
DsecGM10629	DsecGM19198	B4I411	B4I9P3	GM10629.	GM19198.	0.597
DsecGM10629	DsecGM19224	B4I411	B4I9U9	GM10629.	GM19224.	0.972
DsecGM10629	DsecGM19986	B4I411	B4HMK9	GM10629.	GM19986.	0.970
DsecGM10629	DsecGM20273	B4I411	B4HQJ5	GM10629.	GM20273.	0.620
DsecGM10629	DsecGM22414	B4I411	B4ILP4	GM10629.	GM22414; Belongs to the protein kinase superfamily.	0.997
DsecGM10629	Ras85D	B4I411	B4HKC7	GM10629.	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.	0.906
DsecGM11266	DsecGM14496	B4IDX4	B4HTE1	GM11266.	GM14496.	0.826
DsecGM11266	DsecGM15025	B4IDX4	B4IQK9	GM11266.	GM15025.	0.826
DsecGM11266	DsecGM15254	B4IDX4	B4HXA0	GM11266.	GM15254.	0.927
DsecGM11266	DsecGM19196	B4IDX4	B4I9P1	GM11266.	GM19196.	0.738
DsecGM11266	DsecGM19198	B4IDX4	B4I9P3	GM11266.	GM19198.	0.738
DsecGM11266	DsecGM20209	B4IDX4	B4HRD4	GM11266.	GM20209.	0.623
DsecGM11266	DsecGM20273	B4IDX4	B4HQJ5	GM11266.	GM20273.	0.938
DsecGM11266	DsecGM23674	B4IDX4	B4IM61	GM11266.	GM23674.	0.583
DsecGM11266	Ras85D	B4IDX4	B4HKC7	GM11266.	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.	0.839
DsecGM14496	DsecGM11266	B4HTE1	B4IDX4	GM14496.	GM11266.	0.826
DsecGM14496	DsecGM19196	B4HTE1	B4I9P1	GM14496.	GM19196.	0.877