(114 nodes) Negative regulation of cell differentiation network (Drosophila sechellia)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Kibra	Protein kibra; Regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. Kibra acts synergistically along with Ex and Mer to regulate the Hippo signalin [...] (1295 aa)
	DsecGM23598	GM23598. (489 aa)
	Dsecpnt	Pnt. (627 aa)
	DsecGM23574	GM23574. (243 aa)
	DsecGM23572	GM23572. (246 aa)
	DsecGM24682	GM24682. (1378 aa)
	DsecGM26576	GM26576. (1325 aa)
	DsecGM25453	GM25453. (1052 aa)
	DsecGM24557	GM24557. (386 aa)
	DsecGM23939	GM23939. (1765 aa)
	DsecGM24456	GM24456. (1638 aa)
	DsecGM26183	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (499 aa)
	DsecGM26187	GM26187. (682 aa)
	DsecGM24397	GM24397. (444 aa)
	DsecGM26288	GM26288. (671 aa)
	DsecGM25695	GM25695. (398 aa)
	DsecGM24275	GM24275. (1238 aa)
	DsecGM25739	GM25739. (1078 aa)
	DsecGM24835	GM24835. (1159 aa)
	DsecGM21172	GM21172. (341 aa)
	DsecGM19960	GM19960; Belongs to the semaphorin family. (770 aa)
	DsecGM21845	GM21845. (267 aa)
	DsecGM19890	GM19890. (310 aa)
	DsecGM19825	GM19825. (668 aa)
	DsecGM20997	GM20997. (763 aa)
	DsecGM20730	GM20730. (480 aa)
	DsecGM21590	GM21590. (1281 aa)
	DsecGM21087	GM21087. (472 aa)
	DsecGM21695	GM21695; Belongs to the semaphorin family. (784 aa)
	DsecGM21705	GM21705; Belongs to the semaphorin family. (697 aa)
	DsecGM14052	GM14052. (588 aa)
	DsecGM14039	GM14039. (323 aa)
	DsecGM13994	GM13994. (1325 aa)
	DsecGM14658	GM14658. (387 aa)
	DsecGM14673	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (521 aa)
	DsecGM14854	GM14854. (826 aa)
	DsecGM14398	GM14398. (1152 aa)
	DsecGM17569	GM17569. (602 aa)
	DsecGM11890	GM11890. (514 aa)
	DsecGM11080	GM11080. (685 aa)
	DsecGM11073	GM11073. (649 aa)
	DsecGM19546	GM19546. (159 aa)
	DsecGM15894	GM15894. (592 aa)
	DsecGM14165	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (767 aa)
	DsecGM16366	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (468 aa)
	DsecGM16444	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (811 aa)
	DsecGM16609	Serine/threonine-protein phosphatase. (309 aa)
	DsecGM17077	GM17077; Belongs to the semaphorin family. (897 aa)
	DsecGM17087	GM17087. (216 aa)
	DsecGM12650	GM12650. (379 aa)
	DsecGM17464	GM17464. (556 aa)
	DsecGM12386	GM12386. (506 aa)
	DsecGM12795	GM12795. (374 aa)
	DsecGM12874	GM12874. (626 aa)
	DsecGM12875	GM12875. (211 aa)
	DsecGM12904	GM12904. (761 aa)
	DsecGM12905	GM12905. (223 aa)
	DsecGM12129	GM12129. (1096 aa)
	DsecGM12701	GM12701. (888 aa)
	DsecGM17978	GM17978. (70 aa)
	DsecGM17977	GM17977. (1715 aa)
	DsecGM18603	GM18603. (838 aa)
	DsecGM17939	GM17939. (436 aa)
	DsecGM17914	GM17914. (359 aa)
	DsecGM17910	GM17910. (515 aa)
	DsecGM18307	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2217 aa)
	DsecGM18452	GM18452. (1332 aa)
	DsecGM10810	GM10810. (370 aa)
	DsecGM10631	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (438 aa)
	DsecGM10502	GM10502. (233 aa)
	DsecGM17111	GM17111; Cadherins are calcium-dependent cell adhesion proteins. (3151 aa)
	DsecGM17100	GM17100. (840 aa)
	DsecGM17330	GM17330. (1034 aa)
	DsecGM22954	GM22954. (385 aa)
	DsecGM22716	GM22716. (635 aa)
	DsecGM19085	GM19085. (1249 aa)
	DsecGM19086	GM19086. (425 aa)
	DsecGM18927	GM18927. (505 aa)
	DsecGM19264	GM19264. (2671 aa)
	DsecGM22270	GM22270. (576 aa)
	DsecGM15291	GM15291. (607 aa)
	DsecGM15347	GM15347. (2705 aa)
	DsecGM15386	GM15386. (2541 aa)
	DsecAbd-B	Abd-B. (500 aa)
	DsecGM15160	GM15160. (327 aa)
	DsecGM10127	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1410 aa)
	DsecGM16707	GM16707. (1161 aa)
	DsecGM16748	GM16748. (1190 aa)
	DsecGM16662	GM16662; Belongs to the ubiquitin-conjugating enzyme family. (159 aa)
	DsecGM16579	GM16579. (611 aa)
	DsecGM26108	GM26108. (1032 aa)
	DsecGM13369	GM13369. (609 aa)
	DsecGM13428	Phosphoinositide phospholipase C. (807 aa)
	DsecGM11510	GM11510. (509 aa)
	DsecGM26894	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (588 aa)
	DsecGM26915	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (834 aa)
	DsecGM23127	GM23127. (2447 aa)
	DsecGM23187	Signal transducer and activator of transcription. (754 aa)
	DsecGM26814	GM26814. (177 aa)
	DsecGM16442	GM16442. (643 aa)
	DsecGM16443	GM16443. (530 aa)
	DsecGM17761	GM17761. (700 aa)
	DsecGM13101	GM13101. (1225 aa)
	DsecGM13102	GM13102. (135 aa)
	DsecGM22588	GM22588. (435 aa)
	DsecGM15099	GM15099. (510 aa)
	DsecGM11736	Non-specific serine/threonine protein kinase. (909 aa)
	DsecGM16272	GM16272. (73 aa)
	DsecGM23341	GM23341. (1223 aa)
	DsecGM23674	GM23674. (736 aa)
	DsecGM20510	GM20510. (274 aa)
	DsecGM11050	GM11050. (240 aa)
	DsecGM13564	GM13564. (319 aa)
	DsecGM18762	GM18762. (177 aa)

Your Current Organism:

Drosophila sechellia

NCBI taxonomy Id: 7238
Other names: D. sechellia

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DsecAbd-B	DsecGM16366	B4IBQ1	B4HY48	Abd-B.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.426
DsecGM10127	DsecGM11890	B4IC56	B4HWI7	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GM11890.	0.523
DsecGM10127	DsecGM15894	B4IC56	B4HXL8	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GM15894.	0.967
DsecGM10127	DsecGM17464	B4IC56	B4HYX9	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GM17464.	0.864
DsecGM10127	DsecGM19264	B4IC56	B4IA25	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GM19264.	0.999
DsecGM10127	DsecGM22588	B4IC56	B4IKD9	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GM22588.	0.433
DsecGM10127	DsecGM23127	B4IC56	B4II95	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GM23127.	0.664
DsecGM10127	DsecGM26288	B4IC56	B4HKI6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GM26288.	0.620
DsecGM10127	DsecGM26894	B4IC56	B4IHS2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.525
DsecGM10127	DsecGM26915	B4IC56	B4IHW6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.698
DsecGM10502	DsecGM16662	B4I4Q1	B4ICY1	GM10502.	GM16662; Belongs to the ubiquitin-conjugating enzyme family.	0.650
DsecGM10631	DsecGM10810	B4I409	B4I408	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	GM10810.	0.476
DsecGM10631	DsecGM11073	B4I409	B4HX49	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	GM11073.	0.431
DsecGM10631	DsecGM11080	B4I409	B4HX48	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	GM11080.	0.431
DsecGM10631	DsecGM11510	B4I409	B4IGN5	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	GM11510.	0.496
DsecGM10631	DsecGM15894	B4I409	B4HXL8	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	GM15894.	0.709
DsecGM10631	DsecGM16444	B4I409	B4HY61	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.585
DsecGM10631	DsecGM16579	B4I409	B4IDE0	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	GM16579.	0.521
DsecGM10631	DsecGM16662	B4I409	B4ICY1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	GM16662; Belongs to the ubiquitin-conjugating enzyme family.	0.631
DsecGM10631	DsecGM17977	B4I409	B4I1N7	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.	GM17977.	0.529