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DsecGM16610 DsecGM16610 hh hh DsecGM21054 DsecGM21054 DsecGM20113 DsecGM20113 DsecGM13828 DsecGM13828 DsecGM13827 DsecGM13827 DsecGM18758 DsecGM18758 DsecGM18359 DsecGM18359 DsecGM17316 DsecGM17316 DsecGM15814 DsecGM15814 DsecGM15615 DsecGM15615
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DsecGM16610GM16610. (1458 aa)
hhProtein hedgehog C-product; Intercellular signal essential for a variety of patterning events during development. Establishes the anterior-posterior axis of the embryonic segments and patterns the larval imaginal disks. Binds to the patched (ptc) receptor, which functions in association with smoothened (smo), to activate the transcription of target genes wingless (wg), decapentaplegic (dpp) and ptc. In the absence of hh, ptc represses the constitutive signaling activity of smo through fused (fu) (By similarity). The hedgehog protein C-product, which mediates the autocatalytic activity, [...] (465 aa)
DsecGM21054GM21054. (1286 aa)
DsecGM20113GM20113. (1506 aa)
DsecGM13828GM13828. (226 aa)
DsecGM13827GM13827. (337 aa)
DsecGM18758GM18758. (692 aa)
DsecGM18359Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (747 aa)
DsecGM17316GM17316. (434 aa)
DsecGM15814GM15814. (273 aa)
DsecGM15615GM15615. (1429 aa)
Your Current Organism:
Drosophila sechellia
NCBI taxonomy Id: 7238
Other names: D. sechellia
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