(13 nodes) ENTH/VHS network (Drosophila sechellia)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsecGM26431	GM26431. (632 aa)
	DsecGM24632	GM24632. (902 aa)
	DsecGM25149	GM25149. (536 aa)
	DsecGM20171	GM20171. (1933 aa)
	DsecGM14854	GM14854. (826 aa)
	DsecGM14131	GM14131. (375 aa)
	DsecGM18758	GM18758. (692 aa)
	DsecGM18359	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded. (747 aa)
	DsecGM10940	GM10940. (504 aa)
	DsecGM17280	GM17280. (775 aa)
	DsecGM15794	GM15794. (957 aa)
	DsecGM11378	GM11378. (653 aa)
	DsecGM15744	GM15744. (132 aa)

Your Current Organism:

Drosophila sechellia

NCBI taxonomy Id: 7238
Other names: D. sechellia

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DsecGM10940	DsecGM14854	B4I4Q4	B4HV86	GM10940.	GM14854.	0.856
DsecGM10940	DsecGM18758	B4I4Q4	B4HWX3	GM10940.	GM18758.	0.638
DsecGM10940	DsecGM24632	B4I4Q4	B4HG60	GM10940.	GM24632.	0.882
DsecGM10940	DsecGM26431	B4I4Q4	B4HE82	GM10940.	GM26431.	0.670
DsecGM14131	DsecGM17280	B4HW58	B4I5H7	GM14131.	GM17280.	0.934
DsecGM14131	DsecGM20171	B4HW58	B4HRR0	GM14131.	GM20171.	0.740
DsecGM14854	DsecGM10940	B4HV86	B4I4Q4	GM14854.	GM10940.	0.856
DsecGM14854	DsecGM18359	B4HV86	B4I2P0	GM14854.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.737
DsecGM14854	DsecGM18758	B4HV86	B4HWX3	GM14854.	GM18758.	0.690
DsecGM14854	DsecGM24632	B4HV86	B4HG60	GM14854.	GM24632.	0.919
DsecGM14854	DsecGM25149	B4HV86	B4HKQ8	GM14854.	GM25149.	0.572
DsecGM15744	DsecGM20171	B4I7L0	B4HRR0	GM15744.	GM20171.	0.579
DsecGM17280	DsecGM14131	B4I5H7	B4HW58	GM17280.	GM14131.	0.934
DsecGM17280	DsecGM20171	B4I5H7	B4HRR0	GM17280.	GM20171.	0.780
DsecGM18359	DsecGM14854	B4I2P0	B4HV86	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	GM14854.	0.737
DsecGM18359	DsecGM18758	B4I2P0	B4HWX3	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	GM18758.	0.999
DsecGM18758	DsecGM10940	B4HWX3	B4I4Q4	GM18758.	GM10940.	0.638
DsecGM18758	DsecGM14854	B4HWX3	B4HV86	GM18758.	GM14854.	0.690
DsecGM18758	DsecGM18359	B4HWX3	B4I2P0	GM18758.	Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.	0.999
DsecGM20171	DsecGM14131	B4HRR0	B4HW58	GM20171.	GM14131.	0.740