(32 nodes) TGF-beta signaling pathway network (Drosophila sechellia)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsecGM25839	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (516 aa)
	DsecGM24273	GM24273. (782 aa)
	DsecGM21807	GM21807. (1060 aa)
	DsecGM20386	GM20386; Belongs to the SKP1 family. (161 aa)
	DsecGM20983	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (570 aa)
	DsecGM20989	GM20989; Belongs to the cullin family. (774 aa)
	DsecGM21084	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (617 aa)
	DsecGM21657	GM21657. (192 aa)
	DsecGM14019	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (903 aa)
	DsecGM13894	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (490 aa)
	DsecGM14339	GM14339. (122 aa)
	DsecGM14354	GM14354. (199 aa)
	DsecGM18449	GM18449. (879 aa)
	DsecGM16609	Serine/threonine-protein phosphatase. (309 aa)
	DsecGM16909	GM16909. (591 aa)
	DsecGM18031	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (563 aa)
	DsecGM18343	GM18343. (583 aa)
	DsecGM18164	Mothers against decapentaplegic homolog. (545 aa)
	DsecGM22995	GM22995; Belongs to the SKP1 family. (168 aa)
	DsecGM15837	Zinc finger FYVE domain-containing protein. (1345 aa)
	DsecGM15542	GM15542; Belongs to the SKP1 family. (170 aa)
	DsecGM16052	GM16052. (455 aa)
	DsecGM19082	GM19082. (108 aa)
	DsecGM19084	GM19084; Belongs to the SKP1 family. (162 aa)
	DsecGM19268	GM19268. (715 aa)
	DsecGM11351	GM11351. (76 aa)
	DsecGM23275	GM23275. (369 aa)
	DsecGM16436	Mothers against decapentaplegic homolog. (769 aa)
	DsecGM22543	Dorsal-ventral patterning protein Sog; Putative negative growth factor. Antagonist of dpp, a protein involved in patterning the dorsal region and in the development of the neuroectoderm; dpp inhibition is enhanced by tsg. Required for establishment of a narrow stripe of peak levels of BMP signaling in the dorsal midline of early embryos, that will give rise to the amnioserosa. (1038 aa)
	DsecGM13010	GM13010. (948 aa)
	DsecGM11208	Mothers against decapentaplegic homolog. (486 aa)
	DsecGM16932	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (340 aa)

Your Current Organism:

Drosophila sechellia

NCBI taxonomy Id: 7238
Other names: D. sechellia

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DsecGM11208	DsecGM13010	B4IKX2	B4IKR2	Mothers against decapentaplegic homolog.	GM13010.	0.836
DsecGM11208	DsecGM14019	B4IKX2	B4HTZ0	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.868
DsecGM11208	DsecGM14339	B4IKX2	B4HVF8	Mothers against decapentaplegic homolog.	GM14339.	0.901
DsecGM11208	DsecGM15542	B4IKX2	B4I8M5	Mothers against decapentaplegic homolog.	GM15542; Belongs to the SKP1 family.	0.900
DsecGM11208	DsecGM15837	B4IKX2	B4I7Q5	Mothers against decapentaplegic homolog.	Zinc finger FYVE domain-containing protein.	0.999
DsecGM11208	DsecGM16052	B4IKX2	B4I8U4	Mothers against decapentaplegic homolog.	GM16052.	0.593
DsecGM11208	DsecGM16436	B4IKX2	B4IJ10	Mothers against decapentaplegic homolog.	Mothers against decapentaplegic homolog.	0.999
DsecGM11208	DsecGM16932	B4IKX2	B4ILW5	Mothers against decapentaplegic homolog.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.976
DsecGM11208	DsecGM18031	B4IKX2	B4I1E4	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.800
DsecGM11208	DsecGM18343	B4IKX2	B4I2K9	Mothers against decapentaplegic homolog.	GM18343.	0.799
DsecGM11208	DsecGM19082	B4IKX2	B4I946	Mothers against decapentaplegic homolog.	GM19082.	0.901
DsecGM11208	DsecGM19084	B4IKX2	B4I948	Mothers against decapentaplegic homolog.	GM19084; Belongs to the SKP1 family.	0.911
DsecGM11208	DsecGM19268	B4IKX2	B4IA35	Mothers against decapentaplegic homolog.	GM19268.	0.661
DsecGM11208	DsecGM20386	B4IKX2	B4HNX9	Mothers against decapentaplegic homolog.	GM20386; Belongs to the SKP1 family.	0.900
DsecGM11208	DsecGM20983	B4IKX2	B4HR79	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.959
DsecGM11208	DsecGM20989	B4IKX2	B4HR93	Mothers against decapentaplegic homolog.	GM20989; Belongs to the cullin family.	0.910
DsecGM11208	DsecGM21084	B4IKX2	B4HSC7	Mothers against decapentaplegic homolog.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.993
DsecGM11208	DsecGM21807	B4IKX2	B4HMY0	Mothers against decapentaplegic homolog.	GM21807.	0.995
DsecGM11208	DsecGM22543	B4IKX2	B4IK93	Mothers against decapentaplegic homolog.	Dorsal-ventral patterning protein Sog; Putative negative growth factor. Antagonist of dpp, a protein involved in patterning the dorsal region and in the development of the neuroectoderm; dpp inhibition is enhanced by tsg. Required for establishment of a narrow stripe of peak levels of BMP signaling in the dorsal midline of early embryos, that will give rise to the amnioserosa.	0.541
DsecGM11208	DsecGM22995	B4IKX2	B4I7C4	Mothers against decapentaplegic homolog.	GM22995; Belongs to the SKP1 family.	0.900