(25 nodes) Notch signaling pathway, and P domain network (Drosophila simulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD15440	GD15440. (101 aa)
	DsimGD24666	GD24666. (149 aa)
	DsimGD23911	GD23911. (915 aa)
	Su(H)	Su(H). (594 aa)
	DsimGD23180	GD23180. (238 aa)
	DsimGD11355	GD11355. (101 aa)
	DsimGD10998	GD10998. (275 aa)
	DsimGD11000	GD11000. (702 aa)
	DsimGD11001	GD11001. (565 aa)
	DsimGD10200	GD10200. (422 aa)
	DsimGD10199	GD10199. (180 aa)
	DsimGD14885	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (527 aa)
	DsimGD19363	GD19363. (653 aa)
	Dl	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (823 aa)
	DsimGD21138	GD21138. (693 aa)
	DsimGD18200	GD18200; Belongs to the peptidase S8 family. (629 aa)
	DsimGD21265	GD21265. (730 aa)
	DsimGD18089	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1388 aa)
	DsimGD20406	GD20406. (900 aa)
	DsimGD21457	GD21457. (662 aa)
	DsimGD18873	GD18873; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (386 aa)
	N	Notch. (811 aa)
	DsimGD15481	GD15481. (428 aa)
	Fur2	Furin 2; Belongs to the peptidase S8 family. (1428 aa)
	E(spl)	Basic helix-loop-helix transcription factor. (179 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dl	DsimGD14885	B4QTE8	B4QRZ4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.485
Dl	DsimGD15481	B4QTE8	B4R447	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GD15481.	0.425
Dl	DsimGD18089	B4QTE8	B4QXF3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.694
Dl	DsimGD19363	B4QTE8	B4QS09	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GD19363.	0.614
Dl	DsimGD23911	B4QTE8	B4Q539	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GD23911.	0.425
Dl	N	B4QTE8	B4R3W6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch.	0.999
Dl	Su(H)	B4QTE8	B4Q5Z2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Su(H).	0.532
DsimGD10199	DsimGD18089	B4QF86	B4QXF3	GD10199.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.705
DsimGD10199	DsimGD21457	B4QF86	B4R078	GD10199.	GD21457.	0.509
DsimGD10199	DsimGD24666	B4QF86	B4NTP1	GD10199.	GD24666.	0.733
DsimGD10199	Fur2	B4QF86	B4R5T4	GD10199.	Furin 2; Belongs to the peptidase S8 family.	0.510
DsimGD10199	N	B4QF86	B4R3W6	GD10199.	Notch.	0.705
DsimGD10199	Su(H)	B4QF86	B4Q5Z2	GD10199.	Su(H).	0.754
DsimGD10200	DsimGD18089	B4QF85	B4QXF3	GD10200.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.705
DsimGD10200	DsimGD21457	B4QF85	B4R078	GD10200.	GD21457.	0.509
DsimGD10200	DsimGD24666	B4QF85	B4NTP1	GD10200.	GD24666.	0.733
DsimGD10200	Fur2	B4QF85	B4R5T4	GD10200.	Furin 2; Belongs to the peptidase S8 family.	0.510
DsimGD10200	N	B4QF85	B4R3W6	GD10200.	Notch.	0.705
DsimGD10200	Su(H)	B4QF85	B4Q5Z2	GD10200.	Su(H).	0.754
DsimGD10998	DsimGD11000	B4QEX2	B4QEX4	GD10998.	GD11000.	0.576