(12 nodes) Membrane protein ectodomain proteolysis, and Delta serrate ligand network (Drosophila simulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD15440	GD15440. (101 aa)
	DsimGD23911	GD23911. (915 aa)
	DsimGD23180	GD23180. (238 aa)
	DsimGD11355	GD11355. (101 aa)
	DsimGD14885	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (527 aa)
	Dl	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (823 aa)
	DsimGD21138	GD21138. (693 aa)
	DsimGD18089	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1388 aa)
	DsimGD21457	GD21457. (662 aa)
	N	Notch. (811 aa)
	DsimGD15481	GD15481. (428 aa)
	Fur2	Furin 2; Belongs to the peptidase S8 family. (1428 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dl	DsimGD14885	B4QTE8	B4QRZ4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.485
Dl	DsimGD15481	B4QTE8	B4R447	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GD15481.	0.425
Dl	DsimGD18089	B4QTE8	B4QXF3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.694
Dl	DsimGD23911	B4QTE8	B4Q539	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GD23911.	0.425
Dl	N	B4QTE8	B4R3W6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch.	0.999
DsimGD11355	DsimGD14885	B4QCC0	B4QRZ4	GD11355.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.979
DsimGD11355	DsimGD15481	B4QCC0	B4R447	GD11355.	GD15481.	0.599
DsimGD11355	DsimGD18089	B4QCC0	B4QXF3	GD11355.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.558
DsimGD11355	DsimGD21138	B4QCC0	B4QTU0	GD11355.	GD21138.	0.988
DsimGD11355	DsimGD21457	B4QCC0	B4R078	GD11355.	GD21457.	0.705
DsimGD11355	DsimGD23180	B4QCC0	B4Q8K1	GD11355.	GD23180.	0.975
DsimGD11355	DsimGD23911	B4QCC0	B4Q539	GD11355.	GD23911.	0.599
DsimGD11355	Fur2	B4QCC0	B4R5T4	GD11355.	Furin 2; Belongs to the peptidase S8 family.	0.573
DsimGD14885	Dl	B4QRZ4	B4QTE8	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.485
DsimGD14885	DsimGD11355	B4QRZ4	B4QCC0	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	GD11355.	0.979
DsimGD14885	DsimGD15440	B4QRZ4	B4NSL5	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	GD15440.	0.995
DsimGD14885	DsimGD15481	B4QRZ4	B4R447	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	GD15481.	0.717
DsimGD14885	DsimGD18089	B4QRZ4	B4QXF3	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.552
DsimGD14885	DsimGD21138	B4QRZ4	B4QTU0	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	GD21138.	0.999
DsimGD14885	DsimGD21457	B4QRZ4	B4R078	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	GD21457.	0.812