(156 nodes) Cytoplasmic ribonucleoprotein granule, and Post-transcriptional regulation of gene expression network (Drosophila simulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD22146	CG12314 protein. (253 aa)
	DsimGD12042	GD12042. (280 aa)
	DsimGD15398	GD15398. (283 aa)
	DsimGD15225	GD15225. (663 aa)
	DsimGD15443	GD15443. (558 aa)
	DsimGD17651	GD17651. (213 aa)
	DsimGD15121	GD15121. (163 aa)
	DsimGD15170	GD15170. (241 aa)
	DsimGD24551	GD24551. (128 aa)
	DsimGD24474	GD24474. (436 aa)
	DsimGD20883	GD20883. (52 aa)
	DsimGD11648	GD11648. (213 aa)
	DsimGD12039	GD12039. (208 aa)
	DsimGD12260	GD12260. (119 aa)
	DsimGD15006	GD15006. (92 aa)
	DsimGD24355	GD24355. (259 aa)
	DsimGD22686	GD22686. (648 aa)
	DsimGD23828	GD23828. (821 aa)
	DsimGD23375	GD23375; Belongs to the DEAD box helicase family. (403 aa)
	loqs	Loquacious, isoform A. (464 aa)
	Hrb27C	Hrb27C, isoform A. (421 aa)
	DsimGD22464	GD22464. (133 aa)
	DsimGD21970	GD21970. (520 aa)
	DsimGD24003	GD24003. (434 aa)
	DsimGD24037	GD24037. (905 aa)
	DsimGD22367	Drcd-1r. (297 aa)
	DsimGD22864	GD22864. (272 aa)
	DsimGD21867	GD21867. (784 aa)
	DsimGD23138	GD23138. (576 aa)
	DsimGD22312	GD22312. (709 aa)
	DsimGD23655	Importin subunit alpha; Belongs to the importin alpha family. (524 aa)
	DsimGD23667	GD23667; Belongs to the DEAD box helicase family. (459 aa)
	DsimGD23693	GD23693. (1053 aa)
	DsimGD22206	GD22206; Belongs to the argonaute family. (843 aa)
	DsimGD22205	GD22205; Belongs to the argonaute family. (857 aa)
	DsimGD21756	GD21756. (341 aa)
	DsimGD21755	GD21755. (351 aa)
	DsimGD24212	GD24212. (223 aa)
	DsimGD24213	GD24213. (118 aa)
	DsimGD22196	GD22196. (1353 aa)
	DsimGD25978	GD25978. (230 aa)
	DsimGD25958	GD25958. (387 aa)
	DsimGD25020	GD25020. (860 aa)
	DsimGD25012	GD25012. (133 aa)
	DsimGD25009	Peptidylprolyl isomerase. (453 aa)
	DsimGD25000	GD25000. (366 aa)
	Dcr-2	Dcr-2; Belongs to the helicase family. Dicer subfamily. (1666 aa)
	DsimGD24978	GD24978. (227 aa)
	DsimGD25416	GD25416. (1035 aa)
	DsimGD11341	GD11341. (379 aa)
	DsimGD11342	GD11342. (148 aa)
	DsimGD25412	GD25412. (127 aa)
	DsimGD24920	GD24920. (109 aa)
	DsimGD10354	GD10354. (846 aa)
	DsimGD10930	GD10930. (1531 aa)
	DsimGD25797	GD25797. (642 aa)
	DsimGD11509	GD11509. (210 aa)
	AGO1	Argonaute 1. (447 aa)
	DsimGD25717	Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (926 aa)
	DsimGD25256	GD25256. (533 aa)
	DsimGD10519	GD10519. (1310 aa)
	DsimGD25688	GD25688. (553 aa)
	DsimGD11049	GD11049. (195 aa)
	DsimGD25220	U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs. (137 aa)
	DsimGD11573	GD11573. (1608 aa)
	DsimGD11574	GD11574. (824 aa)
	DsimGD10547	GD10547. (238 aa)
	DsimGD25207	GD25207. (540 aa)
	DsimGD10106	GD10106. (366 aa)
	DsimGD10070	GD10070. (2172 aa)
	DsimGD10069	GD10069. (284 aa)
	DsimGD25511	GD25511. (803 aa)
	DsimGD25501	GD25501. (559 aa)
	DsimGD14419	GD14419. (267 aa)
	DsimGD13118	GD13118; Belongs to the eukaryotic initiation factor 4E family. (229 aa)
	DsimGD14504	GD14504. (1577 aa)
	DsimGD14016	GD14016. (445 aa)
	DsimGD12577	GD12577. (81 aa)
	DsimGD15007	GD15007. (180 aa)
	DsimGD14038	GD14038; Belongs to the eukaryotic initiation factor 4E family. (233 aa)
	AGO2	AGO2. (759 aa)
	DsimGD14067	GD14067; Belongs to the eukaryotic initiation factor 4E family. (244 aa)
	DsimGD12535	GD12535. (768 aa)
	DsimGD14580	GD14580. (312 aa)
	DsimGD14106	GD14106. (1389 aa)
	DsimGD14125	GD14125. (267 aa)
	DsimGD12955	GD12955. (889 aa)
	smg	Protein Smaug; Translation regulator that binds to the 3'-UTR of specific mRNAs such as nanos (nos) and prevent their translation. Prevents translation of unlocalized nos in the bulk cytoplasm via the recruitment of cup (By similarity); Belongs to the SMAUG family. (998 aa)
	DsimGD12461	GD12461. (821 aa)
	DsimGD13428	Carbohydrate sulfotransferase. (333 aa)
	DsimGD12928	GD12928; Belongs to the eukaryotic initiation factor 4E family. (269 aa)
	DsimGD12429	GD12429. (140 aa)
	DsimGD12426	GD12426. (60 aa)
	DsimGD12424	GD12424. (119 aa)
	DsimGD12899	GD12899. (374 aa)
	DsimGD12399	GD12399. (676 aa)
	DsimGD13726	PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (786 aa)
	DsimGD13767	GD13767. (859 aa)
	DsimGD12322	GD12322. (175 aa)
	DsimGD14302	GD14302. (283 aa)
	DsimGD12303	ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. (544 aa)
	DsimGD12754	GD12754. (220 aa)
	DsimGD12753	GD12753. (152 aa)
	DsimGD14383	GD14383. (657 aa)
	DsimGD18846	GD18846. (635 aa)
	DsimGD18325	GD18325; Belongs to the eukaryotic initiation factor 4E family. (223 aa)
	DsimGD21592	GD21592. (642 aa)
	DsimGD18311	GD18311. (575 aa)
	DsimGD18310	GD18310. (168 aa)
	DsimGD18302	GD18302. (1008 aa)
	DsimGD21611	GD21611. (298 aa)
	nos	Nanos; Belongs to the nanos family. (385 aa)
	DsimGD20638	GD20638. (1179 aa)
	DsimGD19236	GD19236. (1606 aa)
	msi	Msi. (459 aa)
	DsimGD19743	GD19743; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (562 aa)
	DsimGD20243	GD20243; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (443 aa)
	DsimGD20735	GD20735. (682 aa)
	DsimGD19133	GD19133. (974 aa)
	DsimGD19600	GD19600. (579 aa)
	DsimGD20815	GD20815. (297 aa)
	DsimGD20816	GD20816. (73 aa)
	DsimGD20817	GD20817. (327 aa)
	DsimGD20819	GD20819. (66 aa)
	DsimGD20820	GD20820. (701 aa)
	DsimGD19568	GD19568. (290 aa)
	DsimGD19053	GD19053. (840 aa)
	DsimGD21350	GD21350. (931 aa)
	DsimGD19019	GD19019. (298 aa)
	DsimGD20872	GD20872. (177 aa)
	DsimGD20919	GD20919. (409 aa)
	DsimGD18002	GD18002; Belongs to the eukaryotic initiation factor 4E family. (200 aa)
	DsimGD18972	GD18972. (352 aa)
	DsimGD20928	GD20928. (1338 aa)
	Dcr-1	Dicer-1. (1533 aa)
	DsimGD18428	GD18428. (690 aa)
	DsimGD18427	GD18427. (691 aa)
	DsimGD20486	GD20486. (345 aa)
	DsimGD18393	GD18393. (914 aa)
	DsimGD19374	GD19374. (350 aa)
	DsimGD18349	GD18349. (61 aa)
	DsimGD18348	GD18348. (1658 aa)
	DsimGD21542	GD21542. (472 aa)
	DsimGD24374	GD24374. (1164 aa)
	DsimGD24367	GD24367. (760 aa)
	DsimGD16435	GD16435; Belongs to the eukaryotic initiation factor 4E family. (420 aa)
	DsimGD16260	GD16260. (593 aa)
	DsimGD15762	GD15762. (276 aa)
	DsimGD17286	GD17286. (256 aa)
	DsimGD15702	GD15702. (67 aa)
	Lim1	Lim1. (345 aa)
	DsimGD15637	GD15637. (343 aa)
	DsimGD15636	GD15636. (83 aa)
	Imp	Imp. (204 aa)
	r2d2	R2D2. (311 aa)
	Thor	Thor. (117 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO1	AGO2	B4QEV9	B4QL34	Argonaute 1.	AGO2.	0.690
AGO1	Dcr-1	B4QEV9	B4R0Q6	Argonaute 1.	Dicer-1.	0.994
AGO1	Dcr-2	B4QEV9	B4QBA2	Argonaute 1.	Dcr-2; Belongs to the helicase family. Dicer subfamily.	0.991
AGO1	DsimGD10070	B4QEV9	B4QHA3	Argonaute 1.	GD10070.	0.508
AGO1	DsimGD10519	B4QEV9	B4QF63	Argonaute 1.	GD10519.	0.959
AGO1	DsimGD11341	B4QEV9	B4QBV7	Argonaute 1.	GD11341.	0.665
AGO1	DsimGD11342	B4QEV9	B4QBV8	Argonaute 1.	GD11342.	0.665
AGO1	DsimGD12928	B4QEV9	B4QN56	Argonaute 1.	GD12928; Belongs to the eukaryotic initiation factor 4E family.	0.826
AGO1	DsimGD13118	B4QEV9	B4QJS7	Argonaute 1.	GD13118; Belongs to the eukaryotic initiation factor 4E family.	0.784
AGO1	DsimGD13767	B4QEV9	B4QPJ3	Argonaute 1.	GD13767.	0.485
AGO1	DsimGD14038	B4QEV9	B4QKY1	Argonaute 1.	GD14038; Belongs to the eukaryotic initiation factor 4E family.	0.784
AGO1	DsimGD14067	B4QEV9	B4QLK6	Argonaute 1.	GD14067; Belongs to the eukaryotic initiation factor 4E family.	0.784
AGO1	DsimGD15398	B4QEV9	B4NSF1	Argonaute 1.	GD15398.	0.769
AGO1	DsimGD16435	B4QEV9	B4R2M3	Argonaute 1.	GD16435; Belongs to the eukaryotic initiation factor 4E family.	0.784
AGO1	DsimGD18002	B4QEV9	B4QZE9	Argonaute 1.	GD18002; Belongs to the eukaryotic initiation factor 4E family.	0.787
AGO1	DsimGD18428	B4QEV9	B4R0Q7	Argonaute 1.	GD18428.	0.976
AGO1	DsimGD19019	B4QEV9	B4QYI1	Argonaute 1.	GD19019.	0.761
AGO1	DsimGD19053	B4QEV9	B4QXU0	Argonaute 1.	GD19053.	0.625
AGO1	DsimGD19133	B4QEV9	B4QWC7	Argonaute 1.	GD19133.	0.476
AGO1	DsimGD20735	B4QEV9	B4QVU1	Argonaute 1.	GD20735.	0.915