STRINGSTRING
DsimGD21666 DsimGD21666 DsimGD12001 DsimGD12001 DsimGD15358 DsimGD15358 DsimGD17588 DsimGD17588 DsimGD15188 DsimGD15188 DsimGD24835 DsimGD24835 DsimGD24309 DsimGD24309 DsimGD23929 DsimGD23929 DsimGD23441 DsimGD23441 DsimGD23963 DsimGD23963 DsimGD21967 DsimGD21967 DsimGD21913 DsimGD21913 DsimGD24070 DsimGD24070 DsimGD22823 DsimGD22823 DsimGD24137 DsimGD24137 DsimGD21820 DsimGD21820 DsimGD21819 DsimGD21819 DsimGD24149 DsimGD24149 DsimGD23698 DsimGD23698 DsimGD22755 DsimGD22755 DsimGD22729 DsimGD22729 DsimGD24215 DsimGD24215 DsimGD21742 DsimGD21742 DsimGD22714 DsimGD22714 DsimGD22190 DsimGD22190 DsimGD22189 DsimGD22189 DsimGD23775 DsimGD23775 DsimGD11806 DsimGD11806 Brca2 Brca2 DsimGD25876 DsimGD25876 DsimGD24914 DsimGD24914 DsimGD10317 DsimGD10317 DsimGD25785 DsimGD25785 DsimGD10243 DsimGD10243 DsimGD11503 DsimGD11503 DsimGD25724 DsimGD25724 DsimGD10548 DsimGD10548 DsimGD25620 DsimGD25620 DsimGD25619 DsimGD25619 DsimGD25618 DsimGD25618 DsimGD11667 DsimGD11667 DsimGD11670 DsimGD11670 DsimGD10047 DsimGD10047 Fen1 Fen1 DsimGD13171 DsimGD13171 DsimGD12613 DsimGD12613 DsimGD14503 DsimGD14503 DsimGD14958 DsimGD14958 DsimGD12570 DsimGD12570 DsimGD12080 DsimGD12080 DsimGD13564 DsimGD13564 DsimGD13015 DsimGD13015 DsimGD14084 DsimGD14084 DsimGD12524 DsimGD12524 DsimGD14600 DsimGD14600 DsimGD13488 DsimGD13488 DsimGD12971 DsimGD12971 DsimGD13645 DsimGD13645 DsimGD14135 DsimGD14135 DsimGD13423 DsimGD13423 DsimGD12898 DsimGD12898 DsimGD14249 DsimGD14249 DsimGD13291 DsimGD13291 DsimGD13837 DsimGD13837 DsimGD13208 DsimGD13208 DsimGD14401 DsimGD14401 DsimGD12199 DsimGD12199 DsimGD20640 DsimGD20640 DsimGD18709 DsimGD18709 DsimGD19652 DsimGD19652 DsimGD18149 DsimGD18149 DsimGD19753 DsimGD19753 DsimGD19796 DsimGD19796 DsimGD21329 DsimGD21329 DsimGD20327 DsimGD20327 DsimGD18528 DsimGD18528 DsimGD18526 DsimGD18526 DsimGD20882 DsimGD20882 DsimGD20884 DsimGD20884 DsimGD18521 DsimGD18521 DsimGD20407 DsimGD20407 DsimGD18959 DsimGD18959 DsimGD19968 DsimGD19968 DsimGD18940 DsimGD18940 DsimGD20981 DsimGD20981 DsimGD21012 DsimGD21012 DsimGD17366 DsimGD17366 DsimGD18885 DsimGD18885 DsimGD16439 DsimGD16439 DsimGD15982 DsimGD15982 mei-9 mei-9 Mcm3 Mcm3 DsimGD16723 DsimGD16723 DsimGD16199 DsimGD16199 DsimGD16810 DsimGD16810 DsimGD16811 DsimGD16811 DsimGD16141 DsimGD16141 mei-218 mei-218 DsimGD15662 DsimGD15662 DsimGD17397 DsimGD17397 DsimGD16967 DsimGD16967 DsimGD16035 DsimGD16035 mus209 mus209
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DsimGD21666CG9273 protein. (246 aa)
DsimGD12001GD12001. (783 aa)
DsimGD15358GD15358. (119 aa)
DsimGD17588GD17588. (155 aa)
DsimGD15188GD15188. (307 aa)
DsimGD24835GD24835; Belongs to the PI3/PI4-kinase family. (270 aa)
DsimGD24309GD24309. (775 aa)
DsimGD23929GD23929. (460 aa)
DsimGD23441GD23441. (605 aa)
DsimGD23963GD23963; Component of the post-replicative DNA mismatch repair system (MMR). (879 aa)
DsimGD21967GD21967. (433 aa)
DsimGD21913GD21913. (1707 aa)
DsimGD24070GD24070; Belongs to the protein kinase superfamily. (187 aa)
DsimGD22823GD22823. (110 aa)
DsimGD24137GD24137. (664 aa)
DsimGD21820GD21820. (604 aa)
DsimGD21819GD21819. (119 aa)
DsimGD24149TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (157 aa)
DsimGD23698GD23698. (332 aa)
DsimGD22755ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (663 aa)
DsimGD22729GD22729. (978 aa)
DsimGD24215DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (857 aa)
DsimGD21742Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (255 aa)
DsimGD22714DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (203 aa)
DsimGD22190GD22190. (128 aa)
DsimGD22189GD22189. (227 aa)
DsimGD23775Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (620 aa)
DsimGD11806DNA ligase. (713 aa)
Brca2Breast cancer type 2 susceptibility protein homolog; Involved in and required for double-strand break repair by meiotic and mitotic homologous recombination. During meiosis, has a dual role in the repair of meiotic double-stranded breaks and the efficient activation of the meiotic recombination checkpoint (By similarity). (944 aa)
DsimGD25876GD25876. (202 aa)
DsimGD24914GD24914. (567 aa)
DsimGD10317GD10317. (192 aa)
DsimGD25785GD25785. (721 aa)
DsimGD10243Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (536 aa)
DsimGD11503GD11503. (303 aa)
DsimGD25724GD25724. (893 aa)
DsimGD10548GD10548. (664 aa)
DsimGD25620GD25620. (138 aa)
DsimGD25619GD25619. (713 aa)
DsimGD25618GD25618. (737 aa)
DsimGD11667GD11667. (155 aa)
DsimGD11670GD11670. (1301 aa)
DsimGD10047GD10047. (246 aa)
Fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (385 aa)
DsimGD13171DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (525 aa)
DsimGD12613GD12613. (1009 aa)
DsimGD14503GD14503. (849 aa)
DsimGD14958GD14958. (1115 aa)
DsimGD12570DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1192 aa)
DsimGD12080GD12080. (889 aa)
DsimGD13564DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (940 aa)
DsimGD13015GD13015. (659 aa)
DsimGD14084DNA primase; Belongs to the eukaryotic-type primase small subunit family. (438 aa)
DsimGD12524DNA polymerase. (1096 aa)
DsimGD14600GD14600. (1157 aa)
DsimGD13488GD13488. (196 aa)
DsimGD12971GD12971. (225 aa)
DsimGD13645GD13645. (431 aa)
DsimGD14135DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (607 aa)
DsimGD13423GD13423. (1287 aa)
DsimGD12898Nibrin. (812 aa)
DsimGD14249GD14249. (142 aa)
DsimGD13291GD13291. (331 aa)
DsimGD13837GD13837. (680 aa)
DsimGD13208GD13208. (726 aa)
DsimGD14401GD14401. (633 aa)
DsimGD12199DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (533 aa)
DsimGD20640GD20640. (1473 aa)
DsimGD18709DNA helicase; Belongs to the MCM family. (733 aa)
DsimGD19652Checkpoint protein; Belongs to the HUS1 family. (278 aa)
DsimGD18149DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (228 aa)
DsimGD19753Replication factor C subunit 1. (980 aa)
DsimGD19796GD19796. (198 aa)
DsimGD21329GD21329. (267 aa)
DsimGD20327GD20327; Belongs to the MCM family. (883 aa)
DsimGD18528GD18528; Belongs to the MCM family. (311 aa)
DsimGD18526GD18526. (199 aa)
DsimGD20882Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
DsimGD20884GD20884. (268 aa)
DsimGD18521GD18521. (712 aa)
DsimGD20407GD20407. (535 aa)
DsimGD18959Spindle B. (341 aa)
DsimGD19968DNA polymerase. (847 aa)
DsimGD18940GD18940. (618 aa)
DsimGD20981GD20981. (505 aa)
DsimGD21012DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2104 aa)
DsimGD17366DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (336 aa)
DsimGD18885GD18885. (1333 aa)
DsimGD16439GD16439. (575 aa)
DsimGD15982GD15982. (112 aa)
mei-9Mei-9. (602 aa)
Mcm3Minichromosome maintenance 3. (264 aa)
DsimGD16723GD16723. (68 aa)
DsimGD16199DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (821 aa)
DsimGD16810GD16810. (187 aa)
DsimGD16811DNA helicase; Belongs to the MCM family. (817 aa)
DsimGD16141GD16141. (486 aa)
mei-218Mei-218. (236 aa)
DsimGD15662GD15662. (208 aa)
DsimGD17397GD17397. (242 aa)
DsimGD16967GD16967. (1100 aa)
DsimGD16035GD16035. (212 aa)
mus209Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
Your Current Organism:
Drosophila simulans
NCBI taxonomy Id: 7240
Other names: D. simulans
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