STRINGSTRING
DsimGD21666 DsimGD21666 DsimGD12001 DsimGD12001 DsimGD23963 DsimGD23963 DsimGD22823 DsimGD22823 DsimGD21820 DsimGD21820 DsimGD21819 DsimGD21819 DsimGD22755 DsimGD22755 DsimGD24215 DsimGD24215 DsimGD23775 DsimGD23775 Brca2 Brca2 DsimGD25876 DsimGD25876 DsimGD10548 DsimGD10548 DsimGD25620 DsimGD25620 DsimGD25619 DsimGD25619 DsimGD11670 DsimGD11670 DsimGD12613 DsimGD12613 DsimGD14503 DsimGD14503 DsimGD12570 DsimGD12570 DsimGD13015 DsimGD13015 DsimGD13423 DsimGD13423 DsimGD12898 DsimGD12898 DsimGD13208 DsimGD13208 DsimGD14401 DsimGD14401 DsimGD20640 DsimGD20640 DsimGD19652 DsimGD19652 DsimGD21329 DsimGD21329 DsimGD20882 DsimGD20882 DsimGD18959 DsimGD18959 DsimGD17366 DsimGD17366 DsimGD15982 DsimGD15982 mei-9 mei-9 DsimGD16199 DsimGD16199 DsimGD16141 DsimGD16141 DsimGD17397 DsimGD17397 DsimGD16967 DsimGD16967
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DsimGD21666CG9273 protein. (246 aa)
DsimGD12001GD12001. (783 aa)
DsimGD23963GD23963; Component of the post-replicative DNA mismatch repair system (MMR). (879 aa)
DsimGD22823GD22823. (110 aa)
DsimGD21820GD21820. (604 aa)
DsimGD21819GD21819. (119 aa)
DsimGD22755ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (663 aa)
DsimGD24215DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (857 aa)
DsimGD23775Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (620 aa)
Brca2Breast cancer type 2 susceptibility protein homolog; Involved in and required for double-strand break repair by meiotic and mitotic homologous recombination. During meiosis, has a dual role in the repair of meiotic double-stranded breaks and the efficient activation of the meiotic recombination checkpoint (By similarity). (944 aa)
DsimGD25876GD25876. (202 aa)
DsimGD10548GD10548. (664 aa)
DsimGD25620GD25620. (138 aa)
DsimGD25619GD25619. (713 aa)
DsimGD11670GD11670. (1301 aa)
DsimGD12613GD12613. (1009 aa)
DsimGD14503GD14503. (849 aa)
DsimGD12570DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1192 aa)
DsimGD13015GD13015. (659 aa)
DsimGD13423GD13423. (1287 aa)
DsimGD12898Nibrin. (812 aa)
DsimGD13208GD13208. (726 aa)
DsimGD14401GD14401. (633 aa)
DsimGD20640GD20640. (1473 aa)
DsimGD19652Checkpoint protein; Belongs to the HUS1 family. (278 aa)
DsimGD21329GD21329. (267 aa)
DsimGD20882Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (603 aa)
DsimGD18959Spindle B. (341 aa)
DsimGD17366DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (336 aa)
DsimGD15982GD15982. (112 aa)
mei-9Mei-9. (602 aa)
DsimGD16199DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (821 aa)
DsimGD16141GD16141. (486 aa)
DsimGD17397GD17397. (242 aa)
DsimGD16967GD16967. (1100 aa)
Your Current Organism:
Drosophila simulans
NCBI taxonomy Id: 7240
Other names: D. simulans
Server load: low (28%) [HD]