(5 nodes) MCM N-terminal domain network (Drosophila simulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD14135	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (607 aa)
	DsimGD18709	DNA helicase; Belongs to the MCM family. (733 aa)
	DsimGD18528	GD18528; Belongs to the MCM family. (311 aa)
	Mcm3	Minichromosome maintenance 3. (264 aa)
	DsimGD16811	DNA helicase; Belongs to the MCM family. (817 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DsimGD14135	DsimGD16811	B4QML9	B4R5N4	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
DsimGD14135	DsimGD18528	B4QML9	B4QYN3	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	GD18528; Belongs to the MCM family.	0.999
DsimGD14135	DsimGD18709	B4QML9	B4QUP5	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
DsimGD14135	Mcm3	B4QML9	B4R4S7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Minichromosome maintenance 3.	0.999
DsimGD16811	DsimGD14135	B4R5N4	B4QML9	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
DsimGD16811	DsimGD18528	B4R5N4	B4QYN3	DNA helicase; Belongs to the MCM family.	GD18528; Belongs to the MCM family.	0.999
DsimGD16811	DsimGD18709	B4R5N4	B4QUP5	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
DsimGD16811	Mcm3	B4R5N4	B4R4S7	DNA helicase; Belongs to the MCM family.	Minichromosome maintenance 3.	0.999
DsimGD18528	DsimGD14135	B4QYN3	B4QML9	GD18528; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
DsimGD18528	DsimGD16811	B4QYN3	B4R5N4	GD18528; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
DsimGD18528	DsimGD18709	B4QYN3	B4QUP5	GD18528; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
DsimGD18528	Mcm3	B4QYN3	B4R4S7	GD18528; Belongs to the MCM family.	Minichromosome maintenance 3.	0.999
DsimGD18709	DsimGD14135	B4QUP5	B4QML9	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
DsimGD18709	DsimGD16811	B4QUP5	B4R5N4	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
DsimGD18709	DsimGD18528	B4QUP5	B4QYN3	DNA helicase; Belongs to the MCM family.	GD18528; Belongs to the MCM family.	0.999
DsimGD18709	Mcm3	B4QUP5	B4R4S7	DNA helicase; Belongs to the MCM family.	Minichromosome maintenance 3.	0.999
Mcm3	DsimGD14135	B4R4S7	B4QML9	Minichromosome maintenance 3.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
Mcm3	DsimGD16811	B4R4S7	B4R5N4	Minichromosome maintenance 3.	DNA helicase; Belongs to the MCM family.	0.999
Mcm3	DsimGD18528	B4R4S7	B4QYN3	Minichromosome maintenance 3.	GD18528; Belongs to the MCM family.	0.999
Mcm3	DsimGD18709	B4R4S7	B4QUP5	Minichromosome maintenance 3.	DNA helicase; Belongs to the MCM family.	0.999