(39 nodes) Downstream signaling of activated FGFR4, and Interleukin-3, Interleukin-5 and GM-CSF signaling network (Drosophila simulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD24731	GD24731. (366 aa)
	DsimGD24832	Phosphoinositide phospholipase C. (458 aa)
	DsimGD18487	GD18487. (85 aa)
	DsimGD14194	GD14194. (108 aa)
	Sos	Sos. (1595 aa)
	DsimGD22424	Tyrosine-protein kinase. (621 aa)
	DsimGD23050	GD23050. (548 aa)
	DsimGD22402	GD22402. (443 aa)
	DsimGD10811	GD10811. (724 aa)
	DsimGD10814	GD10814. (749 aa)
	DsimGD10390	Tyrosine-protein kinase. (517 aa)
	drk	Drk. (182 aa)
	DsimGD10226	GD10226; Belongs to the protein kinase superfamily. Tyr protein kinase family. (661 aa)
	DsimGD10225	GD10225. (200 aa)
	DsimGD14480	GD14480. (893 aa)
	DsimGD14481	GD14481. (78 aa)
	DsimGD13480	GD13480. (535 aa)
	DsimGD14094	GD14094. (596 aa)
	DsimGD14660	GD14660; Belongs to the glycosyl hydrolase 1 family. (541 aa)
	DsimGD14181	GD14181. (409 aa)
	DsimGD13693	GD13693. (876 aa)
	DsimGD13248	GD13248; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1163 aa)
	DsimGD21069	GD21069. (508 aa)
	DsimGD20101	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (762 aa)
	DsimGD20204	Fibroblast growth factor receptor. (727 aa)
	DsimGD18966	GD18966. (738 aa)
	DsimGD18965	GD18965. (246 aa)
	DsimGD21505	GD21505. (196 aa)
	Dsimcsw	Csw. (248 aa)
	DsimGD17156	GD17156. (707 aa)
	DsimGD16180	GD16180. (225 aa)
	DsimGD16181	GD16181. (236 aa)
	DsimGD16179	GD16179. (491 aa)
	DsimGD16178	GD16178. (193 aa)
	DsimGD17280	GD17280. (178 aa)
	DsimGD17281	Phosphoinositide phospholipase C. (292 aa)
	DsimGD16840	GD16840. (624 aa)
	DsimGD17440	GD17440. (523 aa)
	DsimGD17441	GD17441. (104 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DsimGD10225	DsimGD10811	B4QER6	B4QBP0	GD10225.	GD10811.	0.442
DsimGD10225	DsimGD10814	B4QER6	B4QBP5	GD10225.	GD10814.	0.442
DsimGD10225	DsimGD14094	B4QER6	B4QM23	GD10225.	GD14094.	0.403
DsimGD10225	DsimGD14181	B4QER6	B4QN62	GD10225.	GD14181.	0.513
DsimGD10225	DsimGD14660	B4QER6	B4QMY1	GD10225.	GD14660; Belongs to the glycosyl hydrolase 1 family.	0.550
DsimGD10225	DsimGD16840	B4QER6	B4R5Y9	GD10225.	GD16840.	0.454
DsimGD10225	DsimGD20101	B4QER6	B4QSU3	GD10225.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.727
DsimGD10225	DsimGD21069	B4QER6	B4QSH0	GD10225.	GD21069.	0.520
DsimGD10225	DsimGD22402	B4QER6	B4Q6T9	GD10225.	GD22402.	0.638
DsimGD10225	Sos	B4QER6	B4Q565	GD10225.	Sos.	0.419
DsimGD10225	drk	B4QER6	B4QEE6	GD10225.	Drk.	0.520
DsimGD10226	DsimGD10811	B4QER5	B4QBP0	GD10226; Belongs to the protein kinase superfamily. Tyr protein kinase family.	GD10811.	0.442
DsimGD10226	DsimGD10814	B4QER5	B4QBP5	GD10226; Belongs to the protein kinase superfamily. Tyr protein kinase family.	GD10814.	0.442
DsimGD10226	DsimGD13693	B4QER5	B4QNJ5	GD10226; Belongs to the protein kinase superfamily. Tyr protein kinase family.	GD13693.	0.931
DsimGD10226	DsimGD14094	B4QER5	B4QM23	GD10226; Belongs to the protein kinase superfamily. Tyr protein kinase family.	GD14094.	0.403
DsimGD10226	DsimGD14181	B4QER5	B4QN62	GD10226; Belongs to the protein kinase superfamily. Tyr protein kinase family.	GD14181.	0.949
DsimGD10226	DsimGD14660	B4QER5	B4QMY1	GD10226; Belongs to the protein kinase superfamily. Tyr protein kinase family.	GD14660; Belongs to the glycosyl hydrolase 1 family.	0.550
DsimGD10226	DsimGD16840	B4QER5	B4R5Y9	GD10226; Belongs to the protein kinase superfamily. Tyr protein kinase family.	GD16840.	0.454
DsimGD10226	DsimGD20101	B4QER5	B4QSU3	GD10226; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.727
DsimGD10226	DsimGD21069	B4QER5	B4QSH0	GD10226; Belongs to the protein kinase superfamily. Tyr protein kinase family.	GD21069.	0.520