193 items (Drosophila simulans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD12069	GD12069. (238 aa)
	R	Roughened. (184 aa)
	Ras85D	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa)
	DsimGD15574	GD15574. (371 aa)
	DsimGD15575	GD15575. (357 aa)
	DsimGD16050	GD16050. (2427 aa)
	DsimGD16951	GD16951. (331 aa)
	DsimGD15625	GD15625. (926 aa)
	Dsor1	Dsor1; Belongs to the protein kinase superfamily. (336 aa)
	DsimGD16093	GD16093. (634 aa)
	DsimGD17375	GD17375; Belongs to the AAA ATPase family. (442 aa)
	DsimGD15666	GD15666. (638 aa)
	DsimGD15668	GD15668. (547 aa)
	oc	GD16101. (631 aa)
	DsimGD17288	GD17288. (404 aa)
	Fur2	Furin 2; Belongs to the peptidase S8 family. (1428 aa)
	DsimGD16225	GD16225. (577 aa)
	DsimGD16321	GD16321. (235 aa)
	N	Notch. (811 aa)
	DsimGD16363	GD16363. (998 aa)
	phl	Phl. (739 aa)
	Dsimcsw	Csw. (248 aa)
	hop	Hop. (524 aa)
	DsimGD17844	GD17844. (295 aa)
	DsimGD16829	GD16829. (994 aa)
	DsimGD19377	GD19377. (494 aa)
	pnt	Pnt. (354 aa)
	DsimGD18390	GD18390. (355 aa)
	DsimGD21010	GD21010. (458 aa)
	DsimGD18409	GD18409. (331 aa)
	DsimGD18916	GD18916. (669 aa)
	DsimGD19397	GD19397. (198 aa)
	DsimGD20989	GD20989. (481 aa)
	DsimGD18424	GD18424. (411 aa)
	DsimGD20428	GD20428. (1029 aa)
	DsimGD20410	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (516 aa)
	DsimGD20405	GD20405. (1320 aa)
	DsimGD21393	GD21393. (493 aa)
	DsimGD21392	GD21392. (1125 aa)
	DsimGD21389	GD21389. (570 aa)
	DsimGD21384	GD21384; Belongs to the DOCK family. (2149 aa)
	DsimGD18530	GD18530. (284 aa)
	DsimGD19023	GD19023. (581 aa)
	DsimGD18067	GD18067. (100 aa)
	DsimGD18068	GD18068. (513 aa)
	DsimGD20836	GD20836. (1693 aa)
	DsimGD20292	GD20292. (1075 aa)
	DsimGD19103	GD19103. (321 aa)
	ksr	Ksr. (967 aa)
	DsimGD18113	GD18113. (345 aa)
	DsimGD18123	GD18123; Belongs to the peptidase S8 family. (654 aa)
	DsimGD21289	GD21289. (2647 aa)
	DsimGD20257	GD20257. (408 aa)
	HLHmdelta	E(Spl) region transcript mdelta. (173 aa)
	boss	Bride of sevenless. (896 aa)
	msi	Msi. (459 aa)
	DsimGD20718	GD20718. (487 aa)
	DsimGD20175	GD20175. (604 aa)
	DsimGD21167	GD21167. (231 aa)
	DsimGD18252	GD18252. (536 aa)
	pros	Prospero. (623 aa)
	tld	Metalloendopeptidase. (1067 aa)
	Dl	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (823 aa)
	DsimGD21608	GD21608. (1826 aa)
	ttk	GD21596. (813 aa)
	DsimGD21088	GD21088. (2287 aa)
	DsimGD21081	GD21081. (1106 aa)
	DsimGD21080	GD21080. (713 aa)
	DsimGD18809	GD18809. (680 aa)
	DsimGD20099	GD20099. (1033 aa)
	DsimGD20095	GD20095. (373 aa)
	DsimGD16557	GD16557. (1315 aa)
	DsimGD21048	AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (156 aa)
	DsimGD18857	GD18857; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (540 aa)
	DsimGD12724	GD12724. (663 aa)
	DsimGD12801	GD12801. (540 aa)
	DsimGD12837	GD12837. (555 aa)
	DsimGD13334	GD13334. (285 aa)
	DsimGD13355	Ubiquitin carboxyl-terminal hydrolase. (826 aa)
	DsimGD13693	GD13693. (876 aa)
	DsimGD14671	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (384 aa)
	DsimGD12903	GD12903. (1459 aa)
	DsimGD12904	GD12904. (375 aa)
	DsimGD12905	GD12905. (1460 aa)
	DsimGD14181	GD14181. (409 aa)
	DsimGD14657	GD14657. (282 aa)
	DsimGD14656	GD14656. (862 aa)
	DsimGD14655	GD14655. (797 aa)
	DsimGD14094	GD14094. (596 aa)
	DsimGD13619	GD13619; Belongs to the peptidase S54 family. (355 aa)
	DsimGD13615	GD13615; Belongs to the peptidase S54 family. (344 aa)
	DsimGD13487	GD13487. (192 aa)
	DsimGD13571	GD13571. (199 aa)
	DsimGD15041	GD15041. (98 aa)
	DsimGD14053	GD14053. (248 aa)
	DsimGD13535	GD13535. (980 aa)
	DsimGD12073	GD12073. (531 aa)
	DsimGD12074	GD12074. (876 aa)
	DsimGD13996	GD13996. (968 aa)
	DsimGD14489	GD14489; Belongs to the G-protein coupled receptor Fz/Smo family. (415 aa)
	DsimGD14462	GD14462. (941 aa)
	DsimGD14461	GD14461. (317 aa)
	DsimGD12647	GD12647. (475 aa)
	DsimGD12667	GD12667. (540 aa)
	DsimGD13173	GD13173. (422 aa)
	DsimGD25042	GD25042. (473 aa)
	DsimGD11235	GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. (449 aa)
	DsimGD25528	GD25528. (1326 aa)
	DsimGD11204	GD11204. (515 aa)
	Lis-1	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes. (411 aa)
	DsimGD11154	GD11154. (971 aa)
	DsimGD10068	GD10068. (751 aa)
	DsimGD25588	GD25588. (1329 aa)
	DsimGD10620	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (601 aa)
	DsimGD11630	GD11630. (176 aa)
	DsimGD11601	GD11601. (705 aa)
	DsimGD11074	GD11074. (106 aa)
	DsimGD25679	GD25679. (439 aa)
	DsimGD25703	GD25703. (2258 aa)
	DsimGD10534	GD10534. (199 aa)
	DsimGD10533	GD10533. (292 aa)
	DsimGD10529	GD10529. (412 aa)
	drk	Drk. (182 aa)
	DsimGD10485	GD10485; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1720 aa)
	DsimGD10253	GD10253. (192 aa)
	DsimGD25317	GD25317. (668 aa)
	DsimGD25786	GD25786. (816 aa)
	DsimGD10943	GD10943; Belongs to the protein kinase superfamily. Tyr protein kinase family. (489 aa)
	DsimGD10283	GD10283. (579 aa)
	DsimGD10903	GD10903. (610 aa)
	DsimGD11399	GD11399. (738 aa)
	DsimGD10849	GD10849; Belongs to the calmodulin family. (149 aa)
	DsimGD10841	GD10841. (694 aa)
	DsimGD24958	GD24958. (441 aa)
	DsimGD24959	GD24959. (470 aa)
	DsimGD24961	GD24961. (1703 aa)
	DsimGD11322	GD11322. (697 aa)
	DsimGD10796	GD10796. (646 aa)
	DsimGD24973	GD24973. (366 aa)
	DsimGD24977	GD24977; Belongs to the actin-binding proteins ADF family. (148 aa)
	DsimGD11802	GD11802. (455 aa)
	DsimGD11258	GD11258. (618 aa)
	DsimGD11257	GD11257. (143 aa)
	DsimGD10750	GD10750; Belongs to the G-protein coupled receptor 2 family. (3463 aa)
	lola	GD25965. (671 aa)
	DsimGD25977	GD25977. (445 aa)
	DsimGD22176	GD22176. (1265 aa)
	DsimGD23276	GD23276. (240 aa)
	DsimGD23275	GD23275. (443 aa)
	DsimGD23274	GD23274. (434 aa)
	DsimGD24230	GD24230. (2043 aa)
	DsimGD22233	ER membrane protein complex subunit 3. (247 aa)
	DsimGD22774	Mothers against decapentaplegic homolog. (440 aa)
	DsimGD22287	GD22287. (443 aa)
	DsimGD23183	GD23183. (586 aa)
	DsimGD21851	GD21851; Cadherins are calcium-dependent cell adhesion proteins. (2044 aa)
	DsimGD21853	GD21853; Cadherins are calcium-dependent cell adhesion proteins. (1402 aa)
	dpp	Dpp. (455 aa)
	DsimGD23147	GD23147. (1983 aa)
	DsimGD22871	GD22871. (716 aa)
	DsimGD23128	E3 ubiquitin-protein ligase. (949 aa)
	DsimGD21910	GD21910. (850 aa)
	DsimGD22924	Adenylyl cyclase-associated protein; Belongs to the CAP family. (786 aa)
	DsimGD23065	GD23065. (800 aa)
	DsimGD22931	GD22931. (596 aa)
	DsimGD23499	GD23499. (786 aa)
	DsimGD23036	GD23036. (355 aa)
	DsimGD23026	GD23026. (1424 aa)
	DsimGD23492	Serine/threonine-protein phosphatase. (309 aa)
	DsimGD22996	GD22996. (1161 aa)
	DsimGD23964	GD23964. (537 aa)
	Sos	Sos. (1595 aa)
	DsimGD23428	GD23428. (1201 aa)
	DsimGD22568	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (771 aa)
	DsimGD22589	GD22589. (1245 aa)
	DsimGD23402	GD23402. (784 aa)
	DsimGD23401	GD23401. (742 aa)
	DsimGD22110	GD22110. (1025 aa)
	DsimGD22628	GD22628. (430 aa)
	DsimGD22659	GD22659. (129 aa)
	DsimGD12271	GD12271; Belongs to the 14-3-3 family. (248 aa)
	DsimGD24394	GD24394. (51 aa)
	DsimGD24558	GD24558. (288 aa)
	DsimGD24731	GD24731. (366 aa)
	DsimGD24642	Mothers against decapentaplegic homolog. (384 aa)
	DsimGD15169	GD15169; Belongs to the 14-3-3 family. (240 aa)
	DsimGD15430	GD15430. (743 aa)
	DsimGD15249	GD15249. (68 aa)
	DsimGD15385	GD15385. (289 aa)
	DsimGD15288	GD15288. (435 aa)
	DsimGD15343	GD15343. (323 aa)
	DsimGD15318	GD15318. (102 aa)
	DsimGD15319	GD15319. (334 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dl	N	B4QTE8	B4R3W6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch.	0.999
DsimGD10253	DsimGD17288	B4QEA9	B4R5V2	GD10253.	GD17288.	0.492
DsimGD10283	DsimGD13487	B4QDT4	B4QLZ5	GD10283.	GD13487.	0.473
DsimGD10485	DsimGD10849	B4QEB4	B4QC96	GD10485; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	GD10849; Belongs to the calmodulin family.	0.664
DsimGD10485	DsimGD11399	B4QEB4	B4QD02	GD10485; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	GD11399.	0.433
DsimGD10485	DsimGD15343	B4QEB4	B4NS45	GD10485; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	GD15343.	0.800
DsimGD10485	DsimGD15625	B4QEB4	B4R712	GD10485; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	GD15625.	0.914
DsimGD10485	DsimGD19397	B4QEB4	B4R145	GD10485; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	GD19397.	0.965
DsimGD10529	DsimGD19103	B4QF81	B4QX24	GD10529.	GD19103.	0.999
DsimGD10533	DsimGD18530	B4QF90	B4QYN0	GD10533.	GD18530.	0.764
DsimGD10533	DsimGD20718	B4QF90	B4QV74	GD10533.	GD20718.	0.577
DsimGD10533	DsimGD21910	B4QF90	B4Q718	GD10533.	GD21910.	0.586
DsimGD10533	DsimGD22568	B4QF90	B4Q4Y0	GD10533.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.912
DsimGD10533	dpp	B4QF90	B4Q848	GD10533.	Dpp.	0.513
DsimGD10533	oc	B4QF90	B4R6K6	GD10533.	GD16101.	0.521
DsimGD10534	DsimGD18530	B4QF91	B4QYN0	GD10534.	GD18530.	0.694
DsimGD10534	DsimGD20718	B4QF91	B4QV74	GD10534.	GD20718.	0.577
DsimGD10534	DsimGD21910	B4QF91	B4Q718	GD10534.	GD21910.	0.586
DsimGD10534	DsimGD22568	B4QF91	B4Q4Y0	GD10534.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.912
DsimGD10534	dpp	B4QF91	B4Q848	GD10534.	Dpp.	0.513