(87 nodes) Motor neuron axon guidance network (Drosophila simulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD24562	GD24562. (124 aa)
	DsimGD22501	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (539 aa)
	DsimGD23056	GD23056. (754 aa)
	DsimGD21931	GD21931. (327 aa)
	DsimGD24036	GD24036. (540 aa)
	DsimGD24038	GD24038. (429 aa)
	DsimGD23104	GD23104. (1306 aa)
	DsimGD23556	GD23556; Belongs to the semaphorin family. (897 aa)
	DsimGD23558	GD23558. (1025 aa)
	DsimGD24100	GD24100. (270 aa)
	DsimGD21879	GD21879. (384 aa)
	DsimGD24118	GD24118. (232 aa)
	DsimGD22277	Cyclin-dependent kinase 5 activator. (470 aa)
	DsimGD21801	GD21801. (534 aa)
	DsimGD21780	GD21780. (438 aa)
	DsimGD21779	GD21779. (122 aa)
	DsimGD22740	GD22740. (1079 aa)
	DsimGD24230	GD24230. (2043 aa)
	DsimGD25793	GD25793. (348 aa)
	DsimGD10938	GD10938. (337 aa)
	DsimGD11036	GD11036. (1092 aa)
	DsimGD25198	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (398 aa)
	DsimGD11111	GD11111. (1066 aa)
	DsimGD25609	GD25609; Belongs to the protein kinase superfamily. (294 aa)
	DsimGD11158	GD11158. (192 aa)
	DsimGD25563	GD25563. (1432 aa)
	DsimGD25109	GD25109. (1429 aa)
	DsimGD10058	GD10058. (500 aa)
	DsimGD14431	GD14431. (737 aa)
	DsimGD14437	GD14437. (433 aa)
	DsimGD14482	GD14482. (583 aa)
	DsimGD12144	GD12144. (596 aa)
	DsimGD13969	POU domain protein. (759 aa)
	DsimGD13984	GD13984. (233 aa)
	DsimGD13988	GD13988. (641 aa)
	DsimGD14965	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (551 aa)
	DsimGD13056	GD13056. (192 aa)
	DsimGD12069	GD12069. (238 aa)
	Lsp1gamma	Larval serum protein 1 gamma. (772 aa)
	DsimGD13487	GD13487. (192 aa)
	DsimGD14132	GD14132. (127 aa)
	DsimGD14134	GD14134; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (560 aa)
	DsimGD12452	GD12452. (1421 aa)
	DsimGD14655	GD14655. (797 aa)
	DsimGD14656	GD14656. (862 aa)
	DsimGD14657	GD14657. (282 aa)
	DsimGD13369	GD13369. (387 aa)
	DsimGD14749	GD14749. (70 aa)
	DsimGD12297	GD12297; Belongs to the G-protein coupled receptor Fz/Smo family. (693 aa)
	DsimGD14812	GD14812. (673 aa)
	DsimGD12253	Guanylate cyclase. (1522 aa)
	NT1	GD13250. (585 aa)
	DsimGD13249	GD13249. (454 aa)
	DsimGD14358	GD14358. (749 aa)
	DsimGD14398	GD14398. (1461 aa)
	DsimGD20542	GD20542. (297 aa)
	DsimGD18786	GD18786. (521 aa)
	tok	Metalloendopeptidase. (1464 aa)
	DsimGD20239	GD20239. (431 aa)
	DsimGD20241	GD20241. (400 aa)
	DsimGD20251	GD20251. (2380 aa)
	DsimGD20299	GD20299. (1114 aa)
	spz	Spz. (350 aa)
	DsimGD18079	GD18079. (939 aa)
	DsimGD21373	GD21373. (332 aa)
	DsimGD21433	GD21433. (83 aa)
	DsimGD21436	GD21436. (878 aa)
	DsimGD18862	GD18862. (329 aa)
	DsimGD20538	GD20538. (300 aa)
	DsimGD21018	GD21018. (446 aa)
	DsimGD21545	GD21545. (1053 aa)
	DsimGD24393	GD24393. (950 aa)
	Ptp10D	Ptp10D. (1316 aa)
	DsimGD16362	GD16362. (3196 aa)
	DsimGD17070	GD17070. (69 aa)
	DsimGD17072	GD17072. (751 aa)
	DsimGD17082	GD17082. (788 aa)
	N	Notch. (811 aa)
	Fas2	Fasciclin 2. (840 aa)
	DsimGD16715	GD16715. (1759 aa)
	DsimGD15846	GD15846. (560 aa)
	DsimGD15845	GD15845. (300 aa)
	DsimNetB	NetB. (503 aa)
	DsimGD16907	GD16907. (601 aa)
	DsimGD17379	GD17379. (948 aa)
	DsimGD16084	GD16084. (113 aa)
	DsimGD17456	GD17456. (191 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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same PNG format, but at higher resolution

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SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

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TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DsimGD10058	DsimGD16362	B4QHP4	B4R3I9	GD10058.	GD16362.	0.414
DsimGD10058	N	B4QHP4	B4R3W6	GD10058.	Notch.	0.676
DsimGD10938	DsimGD22501	B4QDX7	B4Q5E0	GD10938.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.427
DsimGD10938	DsimGD25793	B4QDX7	B4QDX6	GD10938.	GD25793.	0.488
DsimGD11036	DsimGD12069	B4QFF4	B4QKS2	GD11036.	GD12069.	0.733
DsimGD11036	DsimGD17379	B4QFF4	B4R6R2	GD11036.	GD17379.	0.504
DsimGD11111	DsimGD14132	B4QGG3	B4QML6	GD11111.	GD14132.	0.722
DsimGD11111	DsimGD14134	B4QGG3	B4QML8	GD11111.	GD14134; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.722
DsimGD11111	DsimGD15845	B4QGG3	B4R4V2	GD11111.	GD15845.	0.625
DsimGD11111	DsimGD15846	B4QGG3	B4R4V0	GD11111.	GD15846.	0.928
DsimGD11111	DsimGD17379	B4QGG3	B4R6R2	GD11111.	GD17379.	0.763
DsimGD11111	DsimGD23556	B4QGG3	B4Q780	GD11111.	GD23556; Belongs to the semaphorin family.	0.410
DsimGD11111	DsimGD25109	B4QGG3	B4QHL6	GD11111.	GD25109.	0.412
DsimGD11111	DsimNetB	B4QGG3	B4R4V4	GD11111.	NetB.	0.871
DsimGD11158	DsimGD12452	B4QHF0	B4QMW5	GD11158.	GD12452.	0.437
DsimGD11158	DsimGD13056	B4QHF0	B4QKE8	GD11158.	GD13056.	0.722
DsimGD11158	DsimGD13487	B4QHF0	B4QLZ5	GD11158.	GD13487.	0.962
DsimGD11158	DsimGD17456	B4QHF0	B4R7S5	GD11158.	GD17456.	0.738
DsimGD11158	DsimGD23556	B4QHF0	B4Q780	GD11158.	GD23556; Belongs to the semaphorin family.	0.554
DsimGD11158	DsimGD24393	B4QHF0	B4R2D2	GD11158.	GD24393.	0.731