(143 nodes) Regulation of neuron projection development network (Drosophila simulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD15368	GD15368. (1857 aa)
	DsimGD17599	GD17599. (184 aa)
	DsimGD15131	GD15131. (335 aa)
	DsimGD11925	GD11925. (80 aa)
	DsimGD15474	GD15474. (426 aa)
	DsimGD24734	GD24734. (214 aa)
	DsimGD24463	GD24463. (789 aa)
	DsimGD21412	GD21412. (239 aa)
	DsimGD20451	GD20451. (241 aa)
	DsimGD19699	GD19699. (120 aa)
	DsimGD15028	GD15028. (238 aa)
	DsimGD21645	GD21645; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1235 aa)
	chic	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (142 aa)
	DsimGD23850	GD23850. (385 aa)
	DsimGD23862	GD23862; Belongs to the PI3/PI4-kinase family. (2168 aa)
	DsimGD23387	GD23387. (839 aa)
	DsimGD22574	GD22574. (441 aa)
	DsimGD23556	GD23556; Belongs to the semaphorin family. (897 aa)
	DsimGD21853	GD21853; Cadherins are calcium-dependent cell adhesion proteins. (1402 aa)
	DsimGD23669	GD23669; Belongs to the protein kinase superfamily. Tyr protein kinase family. (685 aa)
	DsimGD22287	GD22287. (443 aa)
	DsimGD21809	GD21809. (1112 aa)
	DsimGD23716	GD23716. (342 aa)
	DsimGD23717	GD23717. (600 aa)
	DsimGD21751	GD21751. (1649 aa)
	DsimGD23274	GD23274. (434 aa)
	DsimGD23275	GD23275. (443 aa)
	DsimGD23288	Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (552 aa)
	DsimGD25977	GD25977. (445 aa)
	DsimGD25971	GD25971. (335 aa)
	DsimGD25968	GD25968. (261 aa)
	DsimGD25966	GD25966. (369 aa)
	lola	GD25965. (671 aa)
	DsimGD10750	GD10750; Belongs to the G-protein coupled receptor 2 family. (3463 aa)
	DsimGD25005	GD25005. (531 aa)
	DsimGD25452	GD25452; Belongs to the semaphorin family. (579 aa)
	DsimGD10415	GD10415. (253 aa)
	DsimGD10466	GD10466. (349 aa)
	DsimGD10467	GD10467. (179 aa)
	DsimGD10266	GD10266. (2908 aa)
	DsimGD11498	GD11498. (765 aa)
	DsimGD25734	GD25734. (690 aa)
	DsimGD25733	GD25733. (4046 aa)
	DsimGD10549	GD10549. (174 aa)
	DsimGD25656	GD25656. (633 aa)
	DsimGD11109	GD11109. (414 aa)
	DsimGD25143	GD25143. (753 aa)
	DsimGD25132	GD25132. (196 aa)
	DsimGD11158	GD11158. (192 aa)
	Lis-1	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes. (411 aa)
	DsimGD25109	GD25109. (1429 aa)
	DsimGD11191	GD11191; Belongs to the semaphorin family. (784 aa)
	DsimGD11202	GD11202; Belongs to the semaphorin family. (697 aa)
	DsimGD25516	GD25516; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1753 aa)
	DsimGD11240	GD11240. (2562 aa)
	DsimGD13174	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (517 aa)
	DsimGD12654	GD12654. (531 aa)
	DsimGD14461	GD14461. (317 aa)
	DsimGD14462	GD14462. (941 aa)
	DsimGD14480	GD14480. (893 aa)
	DsimGD14481	GD14481. (78 aa)
	DsimGD13969	POU domain protein. (759 aa)
	DsimGD14489	GD14489; Belongs to the G-protein coupled receptor Fz/Smo family. (415 aa)
	DsimGD13056	GD13056. (192 aa)
	DsimGD13031	GD13031. (1374 aa)
	DsimGD12538	GD12538. (370 aa)
	DsimGD13500	GD13500. (706 aa)
	DsimGD13487	GD13487. (192 aa)
	DsimGD12452	GD12452. (1421 aa)
	DsimGD14666	GD14666. (332 aa)
	DsimGD14181	GD14181. (409 aa)
	DsimGD12905	GD12905. (1460 aa)
	DsimGD12904	GD12904. (375 aa)
	DsimGD12903	GD12903. (1459 aa)
	DsimGD14225	GD14225. (340 aa)
	DsimGD14703	GD14703. (398 aa)
	DsimGD14715	GD14715. (249 aa)
	DsimGD14716	GD14716. (700 aa)
	DsimGD12387	GD12387. (861 aa)
	DsimGD13318	GD13318. (323 aa)
	DsimGD13290	GD13290; Belongs to the STXBP/unc-18/SEC1 family. (176 aa)
	DsimGD12297	GD12297; Belongs to the G-protein coupled receptor Fz/Smo family. (693 aa)
	DsimGD13288	GD13288; Belongs to the peptidase S1 family. (942 aa)
	DsimGD12751	GD12751. (1097 aa)
	Rpd3	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (521 aa)
	DsimGD12245	GD12245; Belongs to the protein kinase superfamily. (459 aa)
	DsimGD13209	GD13209. (170 aa)
	DsimGD13206	GD13206. (100 aa)
	DsimGD13896	GD13896. (2022 aa)
	DsimGD19365	GD19365. (741 aa)
	DsimGD19364	GD19364. (1624 aa)
	DsimGD20048	GD20048; Belongs to the PI3/PI4-kinase family. (1079 aa)
	spas	Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily. (758 aa)
	DsimGD21075	GD21075. (354 aa)
	DsimGD21113	GD21113. (465 aa)
	pros	Prospero. (623 aa)
	DsimGD18249	GD18249. (1247 aa)
	DsimGD18245	GD18245. (596 aa)
	DsimGD20735	GD20735. (682 aa)
	DsimGD19794	GD19794. (182 aa)
	DsimGD19805	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (156 aa)
	DsimGD19806	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (479 aa)
	DsimGD20287	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (405 aa)
	DsimGD20292	GD20292. (1075 aa)
	DsimGD18085	GD18085. (493 aa)
	KATNA1-2	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (668 aa)
	DsimGD19074	Non-specific serine/threonine protein kinase. (530 aa)
	DsimGD19869	Non-specific serine/threonine protein kinase. (701 aa)
	DsimGD20404	GD20404. (351 aa)
	DsimGD20423	GD20423. (1017 aa)
	DsimGD20936	GD20936; Belongs to the small GTPase superfamily. SAR1 family. (193 aa)
	DsimGD19969	GD19969. (156 aa)
	DsimGD18947	GD18947. (341 aa)
	DsimGD19996	GD19996. (205 aa)
	DsimGD18409	GD18409. (331 aa)
	DsimGD16829	GD16829. (994 aa)
	DsimGD24393	GD24393. (950 aa)
	plexA	PlexA. (900 aa)
	DsimGD16554	Non-specific serine/threonine protein kinase. (582 aa)
	DsimGD16584	GD16584. (361 aa)
	DsimGD17039	GD17039. (1079 aa)
	DsimGD17040	GD17040. (150 aa)
	DsimGD15924	GD15924. (964 aa)
	DsimGD15485	GD15485. (370 aa)
	DsimGD16316	GD16316. (2741 aa)
	DsimGD15846	GD15846. (560 aa)
	DsimGD15845	GD15845. (300 aa)
	DsimNetB	NetB. (503 aa)
	DsimGD16213	GD16213. (1161 aa)
	DsimGD17230	GD17230. (1625 aa)
	DsimGD15778	GD15778. (793 aa)
	DsimGD16099	GD16099. (266 aa)
	DsimGD17349	GD17349. (1117 aa)
	DsimGD15629	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (969 aa)
	DsimGD16494	GD16494. (1262 aa)
	DsimGD16956	GD16956. (783 aa)
	DsimGD16957	GD16957. (437 aa)
	DsimGD16051	GD16051. (218 aa)
	DsimGD16047	GD16047. (413 aa)
	DsimGD16046	GD16046. (67 aa)
	DsimGD16044	GD16044. (607 aa)
	Imp	Imp. (204 aa)
	DsimGD17456	GD17456. (191 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DsimGD10266	DsimGD11191	B4QE83	B4QHY5	GD10266.	GD11191; Belongs to the semaphorin family.	0.422
DsimGD10266	DsimGD12751	B4QE83	B4QQS6	GD10266.	GD12751.	0.422
DsimGD10266	DsimGD15846	B4QE83	B4R4V0	GD10266.	GD15846.	0.504
DsimGD10266	DsimGD19364	B4QE83	B4QS07	GD10266.	GD19364.	0.514
DsimGD10266	DsimGD19365	B4QE83	B4QS06	GD10266.	GD19365.	0.514
DsimGD10266	DsimGD19869	B4QE83	B4QYA7	GD10266.	Non-specific serine/threonine protein kinase.	0.474
DsimGD10266	DsimGD20287	B4QE83	B4QX30	GD10266.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.490
DsimGD10266	DsimGD21853	B4QE83	B4Q8C6	GD10266.	GD21853; Cadherins are calcium-dependent cell adhesion proteins.	0.598
DsimGD10266	DsimGD23556	B4QE83	B4Q780	GD10266.	GD23556; Belongs to the semaphorin family.	0.603
DsimGD10266	DsimNetB	B4QE83	B4R4V4	GD10266.	NetB.	0.716
DsimGD10466	DsimGD10750	B4QE77	B4QAL9	GD10466.	GD10750; Belongs to the G-protein coupled receptor 2 family.	0.761
DsimGD10466	DsimGD14489	B4QE77	B4QJZ3	GD10466.	GD14489; Belongs to the G-protein coupled receptor Fz/Smo family.	0.927
DsimGD10466	DsimGD19364	B4QE77	B4QS07	GD10466.	GD19364.	0.501
DsimGD10466	DsimGD19365	B4QE77	B4QS06	GD10466.	GD19365.	0.501
DsimGD10467	DsimGD10750	B4QE78	B4QAL9	GD10467.	GD10750; Belongs to the G-protein coupled receptor 2 family.	0.761
DsimGD10467	DsimGD14489	B4QE78	B4QJZ3	GD10467.	GD14489; Belongs to the G-protein coupled receptor Fz/Smo family.	0.927
DsimGD10467	DsimGD19364	B4QE78	B4QS07	GD10467.	GD19364.	0.501
DsimGD10467	DsimGD19365	B4QE78	B4QS06	GD10467.	GD19365.	0.501
DsimGD10750	DsimGD10466	B4QAL9	B4QE77	GD10750; Belongs to the G-protein coupled receptor 2 family.	GD10466.	0.761
DsimGD10750	DsimGD10467	B4QAL9	B4QE78	GD10750; Belongs to the G-protein coupled receptor 2 family.	GD10467.	0.761