(177 nodes) Programmed cell death network (Drosophila simulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD24241	GD24241; Belongs to the protein kinase superfamily. (459 aa)
	DsimGD23721	GD23721. (660 aa)
	DsimGD23241	GD23241. (547 aa)
	DsimGD22277	Cyclin-dependent kinase 5 activator. (470 aa)
	DsimGD22282	GD22282. (1136 aa)
	DsimGD24140	GD24140. (194 aa)
	DsimGD22854	GD22854. (319 aa)
	DsimGD22855	Endonuclease. (318 aa)
	DsimGD24744	GD24744. (96 aa)
	DsimGD24595	GD24595; Belongs to the protein kinase superfamily. (353 aa)
	DsimGD24757	GD24757. (308 aa)
	DsimGD14372	GD14372. (51 aa)
	DsimGD23355	GD23355; Belongs to the chaperonin (HSP60) family. (576 aa)
	DsimGD23862	GD23862; Belongs to the PI3/PI4-kinase family. (2168 aa)
	DsimGD22074	GD22074. (450 aa)
	DsimGD22056	GD22056; Belongs to the chaperonin (HSP60) family. (558 aa)
	DsimGD22996	GD22996. (1161 aa)
	crq	Crq, isoform A; Belongs to the CD36 family. (491 aa)
	DsimGD23041	GD23041; Belongs to the chaperonin (HSP60) family. (651 aa)
	DsimGD22856	GD22856. (337 aa)
	DsimGD22931	GD22931. (596 aa)
	DsimGD23067	GD23067. (1012 aa)
	DsimGD23096	Dynein light chain. (89 aa)
	DsimGD23134	GD23134. (674 aa)
	DsimGD12008	GD12008. (79 aa)
	DsimGD15253	GD15253. (96 aa)
	DsimGD15194	GD15194. (119 aa)
	DsimGD24723	GD24723. (195 aa)
	Atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (269 aa)
	DsimGD15574	GD15574. (371 aa)
	DsimGD15575	GD15575. (357 aa)
	DsimGD15584	GD15584. (654 aa)
	DsimGD15586	GD15586. (130 aa)
	DsimGD16015	GD16015. (121 aa)
	DsimGD16459	GD16459. (845 aa)
	Dredd	Dredd. (183 aa)
	DsimGD16506	GD16506. (122 aa)
	DsimGD16505	GD16505. (177 aa)
	sws	Sws. (1136 aa)
	DsimGD17275	XK-related protein. (352 aa)
	shi	Shi; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (830 aa)
	DsimGD15774	GD15774. (281 aa)
	DsimGD16213	GD16213. (1161 aa)
	DsimGD16244	GD16244; Belongs to the G-protein coupled receptor 1 family. (419 aa)
	DsimGD17114	Kinase; Belongs to the inositol phosphokinase (IPK) family. (670 aa)
	DsimGD17108	GD17108. (495 aa)
	Dsimanon-072	Anon-072. (2188 aa)
	N	Notch. (811 aa)
	DsimGD16346	GD16346. (805 aa)
	DsimGD16405	GD16405. (169 aa)
	DsimGD16575	GD16575. (176 aa)
	Tak1	Tak1; Belongs to the protein kinase superfamily. (451 aa)
	DsimGD17003	GD17003; Belongs to the chaperonin (HSP60) family. (573 aa)
	DsimGD16829	GD16829. (994 aa)
	DsimGD21513	GD21513. (911 aa)
	DsimGD18409	GD18409. (331 aa)
	DsimGD18411	GD18411. (489 aa)
	DsimGD19979	GD19979. (732 aa)
	DsimGD17638	GD17638. (597 aa)
	DsimGD18428	GD18428. (690 aa)
	Dcr-1	Dicer-1. (1533 aa)
	DsimGD21467	GD21467; Belongs to the peptidase C14A family. (343 aa)
	DsimGD20949	GD20949. (219 aa)
	HtrA2	Serine protease HTRA2, mitochondrial; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase- independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity); Belongs to the peptidase S1C family. (422 aa)
	DsimGD20917	GD20917. (239 aa)
	DsimGD18486	GD18486. (370 aa)
	DsimGD20371	GD20371; Belongs to the PI3/PI4-kinase family. (2694 aa)
	DsimGD21378	GD21378. (370 aa)
	DsimGD21377	Endonuclease. (275 aa)
	DsimGD18024	GD18024. (346 aa)
	DsimGD18025	GD18025. (351 aa)
	DsimGD18028	GD18028. (510 aa)
	DsimGD18541	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (522 aa)
	DsimGD19869	Non-specific serine/threonine protein kinase. (701 aa)
	DsimGD20854	GD20854; Belongs to the DEAD box helicase family. (784 aa)
	DsimGD20813	GD20813. (1345 aa)
	DsimGD20281	GD20281; Belongs to the peptidase C14A family. (302 aa)
	DsimGD19810	GD19810. (1342 aa)
	DsimGD19791	GD19791. (2837 aa)
	DsimGD20268	GD20268. (631 aa)
	DsimGD20723	GD20723. (4013 aa)
	DsimGD19194	GD19194. (471 aa)
	tub	Tub. (447 aa)
	DsimGD18194	GD18194. (1098 aa)
	DsimGD18195	GD18195. (212 aa)
	DsimGD18726	GD18726. (378 aa)
	DsimGD19217	GD19217; Belongs to the LDH/MDH superfamily. (329 aa)
	DsimGD20154	GD20154. (1621 aa)
	DsimGD20610	GD20610. (433 aa)
	Dl	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (823 aa)
	DsimGD21601	GD21601. (246 aa)
	DsimGD21089	GD21089. (1474 aa)
	DsimGD21083	GD21083. (465 aa)
	DsimGD20099	GD20099. (1033 aa)
	DsimGD18327	GD18327. (422 aa)
	DsimGD18328	GD18328. (824 aa)
	DsimGD18839	GD18839. (436 aa)
	trus	GD18840. (485 aa)
	DsimGD14885	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (527 aa)
	DsimGD14414	GD14414. (439 aa)
	DsimGD12695	GD12695; Belongs to the protein kinase superfamily. (261 aa)
	DsimGD12696	GD12696. (346 aa)
	DsimGD13891	GD13891. (1889 aa)
	DsimGD14832	GD14832. (640 aa)
	DsimGD14360	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (111 aa)
	DsimGD14332	GD14332. (255 aa)
	DsimGD13843	GD13843. (387 aa)
	DsimGD14791	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. (481 aa)
	DsimGD12316	GD12316. (314 aa)
	DsimGD14783	GD14783. (430 aa)
	DsimGD14310	GD14310. (299 aa)
	DsimGD14764	GD14764. (141 aa)
	DsimGD12343	GD12343. (218 aa)
	DsimGD14299	GD14299. (481 aa)
	DsimGD12346	GD12346. (65 aa)
	DsimGD12347	GD12347. (136 aa)
	DsimGD12350	GD12350. (410 aa)
	DsimGD13721	GD13721. (242 aa)
	DsimGD12394	GD12394. (303 aa)
	DsimGD12395	GD12395. (928 aa)
	DsimGD14228	GD14228; Belongs to the peptidase C14A family. (449 aa)
	DsimGD12898	Nibrin. (812 aa)
	DsimGD13708	GD13708. (238 aa)
	DsimGD13707	GD13707. (1656 aa)
	DsimGD13445	GD13445. (135 aa)
	DsimGD13447	GD13447. (938 aa)
	DsimGD14127	GD14127. (1393 aa)
	DsimGD12518	GD12518. (430 aa)
	DsimGD13001	GD13001; Belongs to the BI1 family. (244 aa)
	Trap100	Trap100. (993 aa)
	DsimGD14059	GD14059. (435 aa)
	DsimGD13553	GD13553. (249 aa)
	DsimGD12180	GD12180. (206 aa)
	DsimGD11774	GD11774; Belongs to the peptidase C14A family. (323 aa)
	DsimGD11239	GD11239. (1421 aa)
	DsimGD10718	GD10718. (325 aa)
	DsimGD10713	GD10713; Belongs to the tumor necrosis factor family. (415 aa)
	Atg9	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (845 aa)
	DsimGD10706	GD10706; Belongs to the AAA ATPase family. (801 aa)
	DsimGD10057	GD10057; Belongs to the ubiquitin-activating E1 family. (1191 aa)
	DsimGD25563	GD25563. (1432 aa)
	DsimGD11163	GD11163. (710 aa)
	DsimGD10653	GD10653. (350 aa)
	DsimGD10076	GD10076. (372 aa)
	DsimGD25129	GD25129. (392 aa)
	DsimGD25131	GD25131. (254 aa)
	DsimGD11663	GD11663. (499 aa)
	DsimGD25587	GD25587. (498 aa)
	DsimGD25609	GD25609; Belongs to the protein kinase superfamily. (294 aa)
	DsimGD25642	Protein kinase C. (580 aa)
	DsimGD25653	GD25653. (501 aa)
	DsimGD10550	GD10550; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (528 aa)
	DsimGD11568	GD11568. (129 aa)
	DsimGD10217	GD10217; Belongs to the peptidase A1 family. (324 aa)
	DsimGD25317	GD25317. (668 aa)
	DsimGD10952	Transcription factor. (383 aa)
	DsimGD11434	Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (1165 aa)
	DsimGD10412	GD10412. (300 aa)
	DsimGD25379	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. (684 aa)
	DsimGD10334	GD10334. (882 aa)
	DsimGD10341	GD10341; Belongs to the peptidase C14A family. (160 aa)
	DsimGD10356	GD10356. (115 aa)
	DsimGD10849	GD10849; Belongs to the calmodulin family. (149 aa)
	DsimGD10838	GD10838. (258 aa)
	DsimGD10836	GD10836. (297 aa)
	DsimGD25440	XK-related protein. (649 aa)
	DsimGD25880	GD25880; Belongs to the peptidase C14A family. (252 aa)
	DsimGD10809	GD10809. (121 aa)
	Dcr-2	Dcr-2; Belongs to the helicase family. Dicer subfamily. (1666 aa)
	DsimGD11777	Phosphatidylinositol 3-kinase catalytic subunit type 3. (949 aa)
	DsimGD11258	GD11258. (618 aa)
	DsimGD11257	GD11257. (143 aa)
	lola	GD25965. (671 aa)
	DsimGD25966	GD25966. (369 aa)
	DsimGD25968	GD25968. (261 aa)
	DsimGD25971	GD25971. (335 aa)
	DsimGD25977	GD25977. (445 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atg5	Atg9	Q3MQ14	B4QHW9	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.864
Atg5	Dredd	Q3MQ14	B4R7G3	Autophagy protein 5; Involved in autophagic vesicle formation.	Dredd.	0.616
Atg5	DsimGD10057	Q3MQ14	B4QHP5	Autophagy protein 5; Involved in autophagic vesicle formation.	GD10057; Belongs to the ubiquitin-activating E1 family.	0.744
Atg5	DsimGD10217	Q3MQ14	B4QET2	Autophagy protein 5; Involved in autophagic vesicle formation.	GD10217; Belongs to the peptidase A1 family.	0.617
Atg5	DsimGD10356	Q3MQ14	B4QCM7	Autophagy protein 5; Involved in autophagic vesicle formation.	GD10356.	0.518
Atg5	DsimGD10412	Q3MQ14	B4QDA1	Autophagy protein 5; Involved in autophagic vesicle formation.	GD10412.	0.805
Atg5	DsimGD11774	Q3MQ14	B4QIR5	Autophagy protein 5; Involved in autophagic vesicle formation.	GD11774; Belongs to the peptidase C14A family.	0.742
Atg5	DsimGD11777	Q3MQ14	B4QAV9	Autophagy protein 5; Involved in autophagic vesicle formation.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.957
Atg5	DsimGD12180	Q3MQ14	B4QJ42	Autophagy protein 5; Involved in autophagic vesicle formation.	GD12180.	0.801
Atg5	DsimGD12695	Q3MQ14	B4QRR9	Autophagy protein 5; Involved in autophagic vesicle formation.	GD12695; Belongs to the protein kinase superfamily.	0.962
Atg5	DsimGD12696	Q3MQ14	B4QRR8	Autophagy protein 5; Involved in autophagic vesicle formation.	GD12696.	0.962
Atg5	DsimGD13707	Q3MQ14	B4QNL9	Autophagy protein 5; Involved in autophagic vesicle formation.	GD13707.	0.701
Atg5	DsimGD13708	Q3MQ14	B4QNM0	Autophagy protein 5; Involved in autophagic vesicle formation.	GD13708.	0.701
Atg5	DsimGD14059	Q3MQ14	B4QLJ4	Autophagy protein 5; Involved in autophagic vesicle formation.	GD14059.	0.967
Atg5	DsimGD14360	Q3MQ14	B4QR60	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
Atg5	DsimGD14885	Q3MQ14	B4QRZ4	Autophagy protein 5; Involved in autophagic vesicle formation.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.426
Atg5	DsimGD16015	Q3MQ14	B4R7M5	Autophagy protein 5; Involved in autophagic vesicle formation.	GD16015.	0.970
Atg5	DsimGD16213	Q3MQ14	B4R5C8	Autophagy protein 5; Involved in autophagic vesicle formation.	GD16213.	0.584
Atg5	DsimGD17638	Q3MQ14	B4R0T7	Autophagy protein 5; Involved in autophagic vesicle formation.	GD17638.	0.998
Atg5	DsimGD18327	Q3MQ14	B4QSF2	Autophagy protein 5; Involved in autophagic vesicle formation.	GD18327.	0.933