(116 nodes) Extrinsic component of membrane network (Drosophila simulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD12032	Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (282 aa)
	DsimGD15345	GD15345. (619 aa)
	DsimGD15367	GD15367. (201 aa)
	DsimGD17672	GD17672. (306 aa)
	DsimGD17629	GD17629. (312 aa)
	DsimGD15116	GD15116. (139 aa)
	DsimGD11924	GD11924. (134 aa)
	DsimGD24757	GD24757. (308 aa)
	DsimGD24858	GD24858. (777 aa)
	DsimGD24125	GD24125. (87 aa)
	DsimGD22143	GD22143. (1948 aa)
	DsimGD21643	GD21643. (549 aa)
	Sos	Sos. (1595 aa)
	DsimGD23463	GD23463; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (748 aa)
	DsimGD23465	GD23465; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (749 aa)
	DsimGD23016	GD23016. (496 aa)
	DsimGD23592	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
	DsimGD23593	GD23593. (84 aa)
	DsimGD23632	Peptidylprolyl isomerase. (402 aa)
	DsimGD21851	GD21851; Cadherins are calcium-dependent cell adhesion proteins. (2044 aa)
	DsimGD21843	GD21843. (716 aa)
	DsimGD23713	GD23713. (428 aa)
	DsimGD23291	GD23291. (438 aa)
	DsimGD11248	GD11248. (956 aa)
	DsimGD11249	GD11249. (508 aa)
	DsimGD11777	Phosphatidylinositol 3-kinase catalytic subunit type 3. (949 aa)
	DsimGD11807	GD11807. (477 aa)
	DsimGD25447	GD25447. (407 aa)
	DsimGD11812	GD11812. (385 aa)
	DsimGD10390	Tyrosine-protein kinase. (517 aa)
	DsimGD10904	GD10904. (432 aa)
	DsimGD10905	GD10905. (327 aa)
	DsimGD10906	GD10906. (353 aa)
	DsimGD25790	GD25790. (685 aa)
	DsimGD10949	GD10949. (812 aa)
	DsimGD10492	GD10492. (1447 aa)
	DsimGD10493	GD10493. (964 aa)
	DsimGD10544	GD10544. (340 aa)
	DsimGD25233	GD25233. (410 aa)
	DsimGD25232	GD25232. (536 aa)
	DsimGD10596	GD10596. (154 aa)
	DsimGD10597	GD10597. (547 aa)
	DsimGD10610	GD10610. (70 aa)
	DsimGD11116	GD11116. (390 aa)
	DsimGD11117	GD11117. (167 aa)
	DsimGD11169	GD11169. (631 aa)
	DsimGD11170	GD11170. (546 aa)
	DsimGD25560	Tyrosine-protein kinase. (934 aa)
	DsimGD10680	GD10680. (253 aa)
	DsimGD25102	GD25102. (673 aa)
	DsimGD10742	GD10742. (354 aa)
	DsimGD11232	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (700 aa)
	DsimGD11754	GD11754. (157 aa)
	DsimGD13099	GD13099. (355 aa)
	DsimGD17947	GD17947. (180 aa)
	DsimGD14524	GD14524. (633 aa)
	DsimGD13501	GD13501. (812 aa)
	DsimGD13500	GD13500. (706 aa)
	DsimGD14059	GD14059. (435 aa)
	DsimGD14087	GD14087. (576 aa)
	DsimGD12044	GD12044. (250 aa)
	DsimGD12043	GD12043. (192 aa)
	DsimGD13487	GD13487. (192 aa)
	DsimGD12452	GD12452. (1421 aa)
	DsimGD12450	GD12450. (399 aa)
	DsimGD13707	GD13707. (1656 aa)
	DsimGD13708	GD13708. (238 aa)
	Dsim_GD12405	Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. (268 aa)
	DsimGD13325	GD13325. (450 aa)
	DsimGD13814	GD13814; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1071 aa)
	DsimGD13290	GD13290; Belongs to the STXBP/unc-18/SEC1 family. (176 aa)
	DsimGD12785	Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in pigment granule biogenesis. (120 aa)
	DsimGD12776	GD12776; Belongs to the PI3/PI4-kinase family. (1876 aa)
	DsimGD14823	GD14823. (346 aa)
	Src64B	Tyrosine-protein kinase. (552 aa)
	DsimGD14402	GD14402. (3892 aa)
	DsimGD20048	GD20048; Belongs to the PI3/PI4-kinase family. (1079 aa)
	DsimGD20561	GD20561. (687 aa)
	DsimGD18327	GD18327. (422 aa)
	DsimGD21072	GD21072. (1067 aa)
	DsimGD20095	GD20095. (373 aa)
	DsimGD21109	GD21109. (857 aa)
	DsimGD18282	GD18282. (791 aa)
	DsimGD20139	GD20139. (320 aa)
	DsimGD20803	Tyrosine-protein kinase. (1214 aa)
	DsimGD19606	GD19606. (155 aa)
	DsimGD19810	GD19810. (1342 aa)
	DsimGD20813	GD20813. (1345 aa)
	DsimGD18585	GD18585. (340 aa)
	DsimGD18036	GD18036. (126 aa)
	DsimGD18035	GD18035. (278 aa)
	DsimGD18541	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (522 aa)
	DsimGD18515	GD18515; Belongs to the small GTPase superfamily. Arf family. (186 aa)
	DsimGD18014	GD18014. (245 aa)
	DsimGD18013	GD18013. (2135 aa)
	DsimGD19919	GD19919. (468 aa)
	DsimGD18981	Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane. (342 aa)
	DsimGD21414	GD21414. (503 aa)
	DsimGD19436	GD19436. (325 aa)
	DsimGD18927	GD18927. (1507 aa)
	DsimGD18926	GD18926. (775 aa)
	DsimGD20989	GD20989. (481 aa)
	DsimGD17578	GD17578; Belongs to the transient receptor (TC 1.A.4) family. (1272 aa)
	DsimGD21486	GD21486. (2785 aa)
	DsimGD21487	GD21487. (86 aa)
	DsimGD21039	GD21039. (484 aa)
	DsimGD21040	GD21040; Belongs to the DOCK family. (1466 aa)
	DsimGD16405	GD16405. (169 aa)
	DsimGD15974	GD15974. (81 aa)
	DsimGD15912	GD15912. (159 aa)
	DsimGD16687	GD16687. (107 aa)
	DsimGD17206	GD17206. (649 aa)
	DsimGD16207	GD16207. (558 aa)
	DsimGD17247	GD17247. (340 aa)
	DsimGD16125	GD16125. (358 aa)
	DsimGD15663	GD15663. (531 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

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structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

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node degree of proteins in your network (given the current score cut-off)

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DsimGD10390	DsimGD10742	B4QCQ4	B4QID9	Tyrosine-protein kinase.	GD10742.	0.504
DsimGD10390	DsimGD13099	B4QCQ4	B4QJV8	Tyrosine-protein kinase.	GD13099.	0.504
DsimGD10390	DsimGD13487	B4QCQ4	B4QLZ5	Tyrosine-protein kinase.	GD13487.	0.740
DsimGD10390	DsimGD15116	B4QCQ4	B4NT93	Tyrosine-protein kinase.	GD15116.	0.503
DsimGD10390	DsimGD16405	B4QCQ4	B4R322	Tyrosine-protein kinase.	GD16405.	0.441
DsimGD10390	DsimGD20048	B4QCQ4	B4QS08	Tyrosine-protein kinase.	GD20048; Belongs to the PI3/PI4-kinase family.	0.605
DsimGD10390	DsimGD20803	B4QCQ4	B4QWN6	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.545
DsimGD10390	DsimGD23016	B4QCQ4	B4Q624	Tyrosine-protein kinase.	GD23016.	0.611
DsimGD10390	DsimGD25232	B4QCQ4	B4QFK9	Tyrosine-protein kinase.	GD25232.	0.400
DsimGD10390	DsimGD25233	B4QCQ4	B4QFK8	Tyrosine-protein kinase.	GD25233.	0.400
DsimGD10390	Sos	B4QCQ4	B4Q565	Tyrosine-protein kinase.	Sos.	0.748
DsimGD10390	Src64B	B4QCQ4	B4QR05	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.446
DsimGD10492	DsimGD15345	B4QEP2	B4NS47	GD10492.	GD15345.	0.928
DsimGD10493	DsimGD15345	B4QEP3	B4NS47	GD10493.	GD15345.	0.924
DsimGD10610	DsimGD10742	B4QGA2	B4QID9	GD10610.	GD10742.	0.766
DsimGD10610	DsimGD10904	B4QGA2	B4QDD9	GD10610.	GD10904.	0.414
DsimGD10610	DsimGD11812	B4QGA2	B4QBE9	GD10610.	GD11812.	0.672
DsimGD10610	DsimGD12450	B4QGA2	B4QMW7	GD10610.	GD12450.	0.507
DsimGD10610	DsimGD13099	B4QGA2	B4QJV8	GD10610.	GD13099.	0.528
DsimGD10610	DsimGD14823	B4QGA2	B4QQX4	GD10610.	GD14823.	0.678