(61 nodes) Cortical actin cytoskeleton organization network (Drosophila simulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD18441	GD18441. (741 aa)
	DsimGD17456	GD17456. (191 aa)
	DsimGD16093	GD16093. (634 aa)
	DsimGD15680	GD15680. (582 aa)
	shi	Shi; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (830 aa)
	DsimGD19397	GD19397. (198 aa)
	DsimGD17535	GD17535. (742 aa)
	DsimGD18442	GD18442. (1170 aa)
	DsimGD20962	Elongation of very long chain fatty acids protein. (322 aa)
	DsimGD20455	GD20455. (473 aa)
	DsimGD20423	GD20423. (1017 aa)
	DsimGD20399	GD20399. (1467 aa)
	DsimGD20398	GD20398. (1091 aa)
	DsimGD20397	GD20397. (212 aa)
	DsimGD19013	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1243 aa)
	DsimGD19584	GD19584. (985 aa)
	DsimGD18580	GD18580. (611 aa)
	DsimGD18151	GD18151. (113 aa)
	DsimGD18152	GD18152. (552 aa)
	DsimGD19147	GD19147. (154 aa)
	DsimGD20634	GD20634. (1973 aa)
	DsimGD20127	GD20127. (272 aa)
	DsimGD21088	GD21088. (2287 aa)
	DsimGD21072	GD21072. (1067 aa)
	DsimGD14871	GD14871. (558 aa)
	DsimGD12711	Non-specific serine/threonine protein kinase. (1854 aa)
	DsimGD12776	GD12776; Belongs to the PI3/PI4-kinase family. (1876 aa)
	pav	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (928 aa)
	DsimGD14184	GD14184. (81 aa)
	DsimGD14127	GD14127. (1393 aa)
	DsimGD14126	GD14126. (1194 aa)
	DsimGD13487	GD13487. (192 aa)
	DsimGD13592	GD13592. (208 aa)
	DsimGD12535	GD12535. (768 aa)
	DsimGD13031	GD13031. (1374 aa)
	Hem	Hem. (1126 aa)
	DsimGD13099	GD13099. (355 aa)
	DsimGD14478	GD14478. (1277 aa)
	DsimGD10742	GD10742. (354 aa)
	DsimGD11158	GD11158. (192 aa)
	DsimGD25249	GD25249. (790 aa)
	DsimGD25715	GD25715; Belongs to the PI3/PI4-kinase family. (1684 aa)
	DsimGD10494	GD10494. (930 aa)
	DsimGD24961	GD24961. (1703 aa)
	DsimGD24977	GD24977; Belongs to the actin-binding proteins ADF family. (148 aa)
	DsimGD25024	GD25024. (1516 aa)
	DsimGD24255	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (301 aa)
	DsimGD23746	GD23746. (332 aa)
	DsimGD23745	GD23745. (260 aa)
	DsimGD23139	GD23139. (294 aa)
	DsimGD21865	GD21865. (751 aa)
	DsimGD22996	GD22996. (1161 aa)
	DsimGD23389	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (168 aa)
	DsimGD22607	GD22607. (556 aa)
	chic	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (142 aa)
	DsimGD24279	GD24279. (1090 aa)
	DsimGD21691	GD21691. (1285 aa)
	DsimGD22429	GD22429. (83 aa)
	DsimGD15349	GD15349. (61 aa)
	DsimGD15348	GD15348. (603 aa)
	DsimGD15346	GD15346. (719 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DsimGD10494	DsimGD11158	B4QEP6	B4QHF0	GD10494.	GD11158.	0.866
DsimGD10494	DsimGD12711	B4QEP6	B4QRN5	GD10494.	Non-specific serine/threonine protein kinase.	0.954
DsimGD10494	DsimGD13031	B4QEP6	B4QKY2	GD10494.	GD13031.	0.689
DsimGD10494	DsimGD17456	B4QEP6	B4R7S5	GD10494.	GD17456.	0.545
DsimGD10494	DsimGD24279	B4QEP6	B4Q3H5	GD10494.	GD24279.	0.768
DsimGD10494	DsimGD24977	B4QEP6	B4QBH5	GD10494.	GD24977; Belongs to the actin-binding proteins ADF family.	0.601
DsimGD10494	chic	B4QEP6	B4Q452	GD10494.	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	0.438
DsimGD10494	pav	B4QEP6	B4QQI5	GD10494.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.868
DsimGD10742	DsimGD11158	B4QID9	B4QHF0	GD10742.	GD11158.	0.565
DsimGD10742	DsimGD13031	B4QID9	B4QKY2	GD10742.	GD13031.	0.414
DsimGD10742	DsimGD13099	B4QID9	B4QJV8	GD10742.	GD13099.	0.735
DsimGD10742	DsimGD18441	B4QID9	B4R0N6	GD10742.	GD18441.	0.666
DsimGD10742	DsimGD18442	B4QID9	B4R0N5	GD10742.	GD18442.	0.853
DsimGD11158	DsimGD10494	B4QHF0	B4QEP6	GD11158.	GD10494.	0.866
DsimGD11158	DsimGD10742	B4QHF0	B4QID9	GD11158.	GD10742.	0.565
DsimGD11158	DsimGD12711	B4QHF0	B4QRN5	GD11158.	Non-specific serine/threonine protein kinase.	0.976
DsimGD11158	DsimGD13031	B4QHF0	B4QKY2	GD11158.	GD13031.	0.998
DsimGD11158	DsimGD13099	B4QHF0	B4QJV8	GD11158.	GD13099.	0.565
DsimGD11158	DsimGD13487	B4QHF0	B4QLZ5	GD11158.	GD13487.	0.962
DsimGD11158	DsimGD13592	B4QHF0	B4QLX8	GD11158.	GD13592.	0.688