(39 nodes) Post-transcriptional gene silencing by RNA network (Drosophila simulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD12010	GD12010. (603 aa)
	DsimGD12042	GD12042. (280 aa)
	DsimGD15121	GD15121. (163 aa)
	DsimGD15194	GD15194. (119 aa)
	DsimGD24743	GD24743. (306 aa)
	DsimGD14121	GD14121. (202 aa)
	DsimGD24355	GD24355. (259 aa)
	DsimGD24356	GD24356. (1087 aa)
	DsimGD22526	GD22526. (227 aa)
	DsimGD21970	GD21970. (520 aa)
	DsimGD23667	GD23667; Belongs to the DEAD box helicase family. (459 aa)
	DsimGD22205	GD22205; Belongs to the argonaute family. (857 aa)
	DsimGD22196	GD22196. (1353 aa)
	DsimGD25978	GD25978. (230 aa)
	Dcr-2	Dcr-2; Belongs to the helicase family. Dicer subfamily. (1666 aa)
	DsimGD24975	GD24975; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (299 aa)
	Ars2	Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi). Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha (By similarity). (947 aa)
	AGO1	Argonaute 1. (447 aa)
	DsimGD25725	GD25725. (1316 aa)
	DsimGD11245	GD11245. (787 aa)
	DsimGD13105	GD13105. (814 aa)
	DsimGD14504	GD14504. (1577 aa)
	AGO2	AGO2. (759 aa)
	DsimGD12535	GD12535. (768 aa)
	DsimGD13767	GD13767. (859 aa)
	DsimGD13198	GD13198. (257 aa)
	DsimGD21592	GD21592. (642 aa)
	DsimGD16140	GD16140; Belongs to the DEAD box helicase family. (800 aa)
	Cbp20	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp20 recognizes and binds capped RNAs [...] (154 aa)
	DsimGD19568	GD19568. (290 aa)
	DsimGD20854	GD20854; Belongs to the DEAD box helicase family. (784 aa)
	Hsc70-4	Hsc70-4; Belongs to the heat shock protein 70 family. (651 aa)
	Dcr-1	Dicer-1. (1533 aa)
	DsimGD18428	GD18428. (690 aa)
	DsimGD21513	GD21513. (911 aa)
	DsimGD24374	GD24374. (1164 aa)
	DsimGD15970	GD15970. (456 aa)
	DsimGD16701	GD16701. (409 aa)
	DsimGD17202	GD17202. (983 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO1	AGO2	B4QEV9	B4QL34	Argonaute 1.	AGO2.	0.690
AGO1	Dcr-1	B4QEV9	B4R0Q6	Argonaute 1.	Dicer-1.	0.994
AGO1	Dcr-2	B4QEV9	B4QBA2	Argonaute 1.	Dcr-2; Belongs to the helicase family. Dicer subfamily.	0.991
AGO1	DsimGD13767	B4QEV9	B4QPJ3	Argonaute 1.	GD13767.	0.485
AGO1	DsimGD18428	B4QEV9	B4R0Q7	Argonaute 1.	GD18428.	0.976
AGO1	DsimGD21592	B4QEV9	B4QSP4	Argonaute 1.	GD21592.	0.895
AGO1	DsimGD23667	B4QEV9	B4Q8R4	Argonaute 1.	GD23667; Belongs to the DEAD box helicase family.	0.872
AGO1	DsimGD24355	B4QEV9	B4NVX8	Argonaute 1.	GD24355.	0.766
AGO1	DsimGD24374	B4QEV9	B4R2G2	Argonaute 1.	GD24374.	0.999
AGO1	DsimGD25978	B4QEV9	B4QAJ9	Argonaute 1.	GD25978.	0.788
AGO2	AGO1	B4QL34	B4QEV9	AGO2.	Argonaute 1.	0.690
AGO2	Dcr-1	B4QL34	B4R0Q6	AGO2.	Dicer-1.	0.766
AGO2	Dcr-2	B4QL34	B4QBA2	AGO2.	Dcr-2; Belongs to the helicase family. Dicer subfamily.	0.816
AGO2	DsimGD18428	B4QL34	B4R0Q7	AGO2.	GD18428.	0.766
AGO2	DsimGD21970	B4QL34	B4Q5Z7	AGO2.	GD21970.	0.465
AGO2	DsimGD23667	B4QL34	B4Q8R4	AGO2.	GD23667; Belongs to the DEAD box helicase family.	0.583
AGO2	DsimGD24355	B4QL34	B4NVX8	AGO2.	GD24355.	0.538
AGO2	DsimGD24374	B4QL34	B4R2G2	AGO2.	GD24374.	0.890
AGO2	DsimGD25978	B4QL34	B4QAJ9	AGO2.	GD25978.	0.654
Ars2	Cbp20	B4QCR6	B4QV17	Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and RNA-mediated gene silencing (RNAi). Involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. Also involved microRNA (miRNA)-mediated silencing by contributing to the stability and delivery of primary miRNA transcripts to the primary miRNA processing complex containing drosha and pasha (By similarity).	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference via its interaction with Ars2 and is required for primary microRNAs (miRNAs) processing. Also involved in innate immunity via the short interfering RNAs (siRNAs) processing machinery by restricting the viral RNA production. In the CBC complex, Cbp20 recognizes and binds capped RNAs [...]	0.993