(49 nodes) Negative regulation of hippo signaling network (Drosophila simulans)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	R	Roughened. (184 aa)
	DsimGD25582	GD25582. (1330 aa)
	DsimGD25469	GD25469. (355 aa)
	DsimGD23128	E3 ubiquitin-protein ligase. (949 aa)
	DsimGD23548	GD23548; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1232 aa)
	DsimGD23530	GD23530. (590 aa)
	DsimGD23499	GD23499. (786 aa)
	DsimGD22944	GD22944. (3038 aa)
	DsimGD23492	Serine/threonine-protein phosphatase. (309 aa)
	DsimGD22529	GD22529. (302 aa)
	DsimGD23919	Mitogen-activated protein kinase. (365 aa)
	DsimGD22171	GD22171. (1915 aa)
	DsimGD13210	GD13210. (318 aa)
	DsimGD24427	GD24427. (343 aa)
	ci	Cubitus interruptus, isoform A. (1402 aa)
	lic	Licorne. (334 aa)
	DsimGD24798	GD24798. (100 aa)
	DsimGD24797	GD24797; Belongs to the protein kinase superfamily. (157 aa)
	DsimGD24618	GD24618. (251 aa)
	DsimGD25581	GD25581. (3733 aa)
	DsimGD13608	GD13608. (1058 aa)
	DsimGD13333	GD13333. (361 aa)
	DsimGD25642	Protein kinase C. (580 aa)
	DsimGD11020	GD11020. (1744 aa)
	DsimGD25720	GD25720. (968 aa)
	DsimGD10516	GD10516; Belongs to the cullin family. (774 aa)
	DsimGD10225	GD10225. (200 aa)
	DsimGD10226	GD10226; Belongs to the protein kinase superfamily. Tyr protein kinase family. (661 aa)
	DsimGD11459	GD11459. (357 aa)
	DsimGD25583	GD25583. (1307 aa)
	DsimGD10311	GD10311. (223 aa)
	DsimGD11404	GD11404. (123 aa)
	DsimGD11403	GD11403. (283 aa)
	DsimGD11305	GD11305. (455 aa)
	DsimGD11296	GD11296. (1060 aa)
	DsimGD11292	GD11292. (839 aa)
	DsimGD25467	GD25467. (1310 aa)
	DsimGD13332	GD13332. (286 aa)
	DsimGD13814	GD13814; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1071 aa)
	DsimGD12711	Non-specific serine/threonine protein kinase. (1854 aa)
	DsimGD16381	GD16381. (200 aa)
	DsimGD20154	GD20154. (1621 aa)
	DsimGD19074	Non-specific serine/threonine protein kinase. (530 aa)
	DsimGD20006	GD20006. (510 aa)
	DsimGD18406	GD18406. (806 aa)
	DsimGD24360	GD24360. (584 aa)
	DsimGD15945	GD15945; Belongs to the peptidase C19 family. (1129 aa)
	DsimGD15658	GD15658. (911 aa)
	DsimGD16521	GD16521; Belongs to the SKP1 family. (162 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DsimGD10311	DsimGD13332	B4QDB6	B4QPH8	GD10311.	GD13332.	0.822
DsimGD10311	DsimGD13333	B4QDB6	B4QPH7	GD10311.	GD13333.	0.822
DsimGD10311	DsimGD22529	B4QDB6	B4Q598	GD10311.	GD22529.	0.929
DsimGD10311	DsimGD23492	B4QDB6	B4Q5U3	GD10311.	Serine/threonine-protein phosphatase.	0.852
DsimGD10311	DsimGD23499	B4QDB6	B4Q689	GD10311.	GD23499.	0.916
DsimGD10311	DsimGD23530	B4QDB6	B4Q6R7	GD10311.	GD23530.	0.890
DsimGD10516	DsimGD15945	B4QEU0	B4R3L3	GD10516; Belongs to the cullin family.	GD15945; Belongs to the peptidase C19 family.	0.465
DsimGD10516	DsimGD16521	B4QEU0	B4R7G7	GD10516; Belongs to the cullin family.	GD16521; Belongs to the SKP1 family.	0.999
DsimGD10516	DsimGD19074	B4QEU0	B4QXQ5	GD10516; Belongs to the cullin family.	Non-specific serine/threonine protein kinase.	0.552
DsimGD10516	DsimGD20006	B4QEU0	B4R143	GD10516; Belongs to the cullin family.	GD20006.	0.999
DsimGD10516	DsimGD23492	B4QEU0	B4Q5U3	GD10516; Belongs to the cullin family.	Serine/threonine-protein phosphatase.	0.644
DsimGD10516	DsimGD23530	B4QEU0	B4Q6R7	GD10516; Belongs to the cullin family.	GD23530.	0.550
DsimGD10516	DsimGD24797	B4QEU0	B4NUC3	GD10516; Belongs to the cullin family.	GD24797; Belongs to the protein kinase superfamily.	0.539
DsimGD10516	DsimGD24798	B4QEU0	B4NUC4	GD10516; Belongs to the cullin family.	GD24798.	0.539
DsimGD10516	ci	B4QEU0	B4NUI3	GD10516; Belongs to the cullin family.	Cubitus interruptus, isoform A.	0.980
DsimGD11020	DsimGD24427	B4QFC8	B4NUV7	GD11020.	GD24427.	0.829
DsimGD11292	DsimGD13814	B4QB98	B4QQ42	GD11292.	GD13814; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.478
DsimGD11292	DsimGD20006	B4QB98	B4R143	GD11292.	GD20006.	0.570
DsimGD11292	DsimGD22171	B4QB98	B4Q372	GD11292.	GD22171.	0.461
DsimGD11296	DsimGD19074	B4QBA9	B4QXQ5	GD11296.	Non-specific serine/threonine protein kinase.	0.411