25 items (Drosophila simulans) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD23254	GD23254. (1439 aa)
	DsimGD24871	GD24871. (203 aa)
	DsimGD24377	GD24377. (243 aa)
	DsimGD24448	GD24448. (113 aa)
	DsimGD23059	GD23059. (185 aa)
	DsimGD23128	E3 ubiquitin-protein ligase. (949 aa)
	DsimGD23242	GD23242. (81 aa)
	DsimGD22744	GD22744. (576 aa)
	DsimGD22743	GD22743. (391 aa)
	DsimGD24977	GD24977; Belongs to the actin-binding proteins ADF family. (148 aa)
	DsimGD10352	GD10352. (469 aa)
	DsimGD11656	GD11656. (130 aa)
	DsimGD12147	Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2731 aa)
	DsimGD14977	GD14977. (461 aa)
	DsimGD12888	GD12888; Belongs to the protein kinase superfamily. (451 aa)
	DsimGD14832	GD14832. (640 aa)
	Dl	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (823 aa)
	DsimGD18145	GD18145. (644 aa)
	DsimGD20292	GD20292. (1075 aa)
	DsimGD20825	GD20825. (424 aa)
	DsimGD18089	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1388 aa)
	DsimGD20395	GD20395; Belongs to the cyclin family. (267 aa)
	N	Notch. (811 aa)
	DsimGD17400	GD17400. (371 aa)
	DsimGD17439	GD17439. (88 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dl	DsimGD18089	B4QTE8	B4QXF3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.694
Dl	N	B4QTE8	B4R3W6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch.	0.999
DsimGD10352	DsimGD17400	B4QCN8	B4R708	GD10352.	GD17400.	0.918
DsimGD12147	DsimGD12888	B4QJL8	B4QNQ1	Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	GD12888; Belongs to the protein kinase superfamily.	0.995
DsimGD12147	DsimGD14832	B4QJL8	B4QRC0	Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	GD14832.	0.997
DsimGD12147	DsimGD20395	B4QJL8	B4QZ73	Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	GD20395; Belongs to the cyclin family.	0.993
DsimGD12888	DsimGD12147	B4QNQ1	B4QJL8	GD12888; Belongs to the protein kinase superfamily.	Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.995
DsimGD12888	DsimGD14832	B4QNQ1	B4QRC0	GD12888; Belongs to the protein kinase superfamily.	GD14832.	0.996
DsimGD12888	DsimGD20395	B4QNQ1	B4QZ73	GD12888; Belongs to the protein kinase superfamily.	GD20395; Belongs to the cyclin family.	0.999
DsimGD14832	DsimGD12147	B4QRC0	B4QJL8	GD14832.	Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.997
DsimGD14832	DsimGD12888	B4QRC0	B4QNQ1	GD14832.	GD12888; Belongs to the protein kinase superfamily.	0.996
DsimGD14832	DsimGD20395	B4QRC0	B4QZ73	GD14832.	GD20395; Belongs to the cyclin family.	0.996
DsimGD17400	DsimGD10352	B4R708	B4QCN8	GD17400.	GD10352.	0.918
DsimGD18089	Dl	B4QXF3	B4QTE8	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.694
DsimGD18089	N	B4QXF3	B4R3W6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch.	0.999
DsimGD18145	DsimGD20825	B4QW30	B4QXB0	GD18145.	GD20825.	0.988
DsimGD20292	DsimGD20825	B4QX40	B4QXB0	GD20292.	GD20825.	0.996
DsimGD20395	DsimGD12147	B4QZ73	B4QJL8	GD20395; Belongs to the cyclin family.	Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.993
DsimGD20395	DsimGD12888	B4QZ73	B4QNQ1	GD20395; Belongs to the cyclin family.	GD12888; Belongs to the protein kinase superfamily.	0.999
DsimGD20395	DsimGD14832	B4QZ73	B4QRC0	GD20395; Belongs to the cyclin family.	GD14832.	0.996