(53 nodes) Wing disc dorsal/ventral pattern formation network (Drosophila simulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD15323	GD15323. (134 aa)
	Dsimosa	Osa. (752 aa)
	DsimGD15169	GD15169; Belongs to the 14-3-3 family. (240 aa)
	DsimGD24871	GD24871. (203 aa)
	DsimGD23471	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (795 aa)
	DsimGD23492	Serine/threonine-protein phosphatase. (309 aa)
	Su(H)	Su(H). (594 aa)
	cbt	Cabut, isoform A. (428 aa)
	DsimGD22924	Adenylyl cyclase-associated protein; Belongs to the CAP family. (786 aa)
	DsimGD23128	E3 ubiquitin-protein ligase. (949 aa)
	DsimGD22831	GD22831; Belongs to the STXBP/unc-18/SEC1 family. (625 aa)
	DsimGD23194	GD23194. (1580 aa)
	DsimGD22279	GD22279; Belongs to the AAA ATPase family. (341 aa)
	DsimGD10771	GD10771. (2580 aa)
	DsimGD24976	GD24976. (302 aa)
	DsimGD25399	GD25399. (1775 aa)
	DsimGD25398	GD25398. (509 aa)
	DsimGD10352	GD10352. (469 aa)
	DsimGD25357	GD25357. (416 aa)
	DsimGD10928	GD10928. (453 aa)
	DsimGD11155	GD11155. (886 aa)
	DsimGD12163	GD12163. (920 aa)
	DsimGD12147	Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2731 aa)
	DsimGD14485	GD14485. (66 aa)
	DsimGD14486	GD14486. (98 aa)
	DsimGD14491	GD14491; Belongs to the mitochondrial carrier (TC 2.A.29) family. (356 aa)
	DsimGD14495	GD14495; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (813 aa)
	DsimGD14046	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (430 aa)
	DsimGD14589	GD14589. (671 aa)
	DsimGD13447	GD13447. (938 aa)
	DsimGD14132	GD14132. (127 aa)
	DsimGD14134	GD14134; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (560 aa)
	DsimGD12326	GD12326. (811 aa)
	DsimGD17914	GD17914. (374 aa)
	DsimGD12242	GD12242. (1056 aa)
	DsimGD14885	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (527 aa)
	DsimGD19363	GD19363. (653 aa)
	DsimGD19345	GD19345. (1406 aa)
	DsimGD21052	GD21052. (90 aa)
	DsimGD21088	GD21088. (2287 aa)
	Dl	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (823 aa)
	DsimGD20218	GD20218. (640 aa)
	DsimGD21239	GD21239. (206 aa)
	DsimGD20299	GD20299. (1114 aa)
	DsimGD19083	GD19083. (914 aa)
	DsimGD19907	GD19907. (118 aa)
	DsimGD19393	Annexin. (341 aa)
	DsimGD18407	GD18407. (502 aa)
	DsimGD18390	GD18390. (355 aa)
	N	Notch. (811 aa)
	DsimGD15897	GD15897. (1773 aa)
	DsimGD17439	GD17439. (88 aa)
	HLHmgamma	Enhancer of split complex mgamma protein. (205 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Dl	DsimGD14885	B4QTE8	B4QRZ4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.485
Dl	DsimGD19363	B4QTE8	B4QS09	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GD19363.	0.614
Dl	N	B4QTE8	B4R3W6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch.	0.999
Dl	Su(H)	B4QTE8	B4Q5Z2	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Su(H).	0.532
DsimGD10352	DsimGD10928	B4QCN8	B4QDI6	GD10352.	GD10928.	0.454
DsimGD10771	DsimGD23128	B4QB33	B4Q7L9	GD10771.	E3 ubiquitin-protein ligase.	0.498
DsimGD10928	DsimGD10352	B4QDI6	B4QCN8	GD10928.	GD10352.	0.454
DsimGD10928	DsimGD15897	B4QDI6	B4R4A1	GD10928.	GD15897.	0.438
DsimGD12242	DsimGD19393	B4QRC6	B4R154	GD12242.	Annexin.	0.427
DsimGD12242	DsimGD23194	B4QRC6	B4Q8N0	GD12242.	GD23194.	0.994
DsimGD12326	N	B4QPW2	B4R3W6	GD12326.	Notch.	0.520
DsimGD14132	DsimGD14495	B4QML6	B4QK11	GD14132.	GD14495; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.536
DsimGD14132	DsimGD14589	B4QML6	B4QLT1	GD14132.	GD14589.	0.848
DsimGD14132	DsimGD20299	B4QML6	B4QX53	GD14132.	GD20299.	0.554
DsimGD14134	DsimGD14495	B4QML8	B4QK11	GD14134; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	GD14495; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.572
DsimGD14134	DsimGD14589	B4QML8	B4QLT1	GD14134; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	GD14589.	0.848
DsimGD14134	DsimGD20299	B4QML8	B4QX53	GD14134; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	GD20299.	0.554
DsimGD14495	DsimGD14132	B4QK11	B4QML6	GD14495; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	GD14132.	0.536
DsimGD14495	DsimGD14134	B4QK11	B4QML8	GD14495; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	GD14134; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.572
DsimGD14495	DsimGD14589	B4QK11	B4QLT1	GD14495; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	GD14589.	0.901