(143 nodes) Regulation of neurogenesis network (Drosophila simulans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DsimGD15323	GD15323. (134 aa)
	DsimGD15288	GD15288. (435 aa)
	DsimGD17722	GD17722. (152 aa)
	DsimGD15118	GD15118. (266 aa)
	Dsimosa	Osa. (752 aa)
	DsimGD15194	GD15194. (119 aa)
	DsimGD24642	Mothers against decapentaplegic homolog. (384 aa)
	DsimGD24734	GD24734. (214 aa)
	DsimGD24822	GD24822. (112 aa)
	DsimGD24871	GD24871. (203 aa)
	DsimGD20997	GD20997. (55 aa)
	DsimGD20451	GD20451. (241 aa)
	DsimGD21654	GD21654. (606 aa)
	DsimGD21653	GD21653. (484 aa)
	chic	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (142 aa)
	DsimGD22110	GD22110. (1025 aa)
	DsimGD23844	POU domain protein. (601 aa)
	DsimGD23850	GD23850. (385 aa)
	DsimGD22576	GD22576. (433 aa)
	DsimGD22996	GD22996. (1161 aa)
	DsimGD23492	Serine/threonine-protein phosphatase. (309 aa)
	DsimGD23499	GD23499. (786 aa)
	DsimGD21956	GD21956. (548 aa)
	DsimGD23556	GD23556; Belongs to the semaphorin family. (897 aa)
	DsimGD23563	GD23563. (489 aa)
	DsimGD22883	GD22883. (620 aa)
	DsimGD22871	GD22871. (716 aa)
	DsimGD23607	GD23607. (556 aa)
	DsimGD22349	GD22349. (504 aa)
	DsimGD21853	GD21853; Cadherins are calcium-dependent cell adhesion proteins. (1402 aa)
	DsimGD23183	GD23183. (586 aa)
	DsimGD24173	GD24173. (507 aa)
	DsimGD24188	GD24188. (547 aa)
	DsimGD24189	GD24189. (378 aa)
	DsimGD23268	GD23268. (1293 aa)
	DsimGD10750	GD10750; Belongs to the G-protein coupled receptor 2 family. (3463 aa)
	DsimGD25452	GD25452; Belongs to the semaphorin family. (579 aa)
	DsimGD24973	GD24973. (366 aa)
	DsimGD10811	GD10811. (724 aa)
	DsimGD11322	GD11322. (697 aa)
	DsimGD25375	GD25375. (310 aa)
	DsimGD11921	GD11921. (498 aa)
	DsimGD10311	GD10311. (223 aa)
	DsimGD25317	GD25317. (668 aa)
	DsimGD10466	GD10466. (349 aa)
	DsimGD10467	GD10467. (179 aa)
	DsimGD25734	GD25734. (690 aa)
	DsimGD25733	GD25733. (4046 aa)
	DsimGD10200	GD10200. (422 aa)
	DsimGD10199	GD10199. (180 aa)
	DsimGD11091	GD11091. (207 aa)
	DsimGD25642	Protein kinase C. (580 aa)
	DsimGD11109	GD11109. (414 aa)
	DsimGD10620	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (601 aa)
	DsimGD10624	GD10624. (474 aa)
	DsimGD25143	GD25143. (753 aa)
	Lis-1	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes. (411 aa)
	DsimGD11191	GD11191; Belongs to the semaphorin family. (784 aa)
	DsimGD11202	GD11202; Belongs to the semaphorin family. (697 aa)
	DsimGD13166	GD13166. (564 aa)
	DsimGD12654	GD12654. (531 aa)
	DsimGD14461	GD14461. (317 aa)
	DsimGD14462	GD14462. (941 aa)
	DsimGD14480	GD14480. (893 aa)
	DsimGD14481	GD14481. (78 aa)
	DsimGD14489	GD14489; Belongs to the G-protein coupled receptor Fz/Smo family. (415 aa)
	DsimGD12119	GD12119. (605 aa)
	DsimGD12525	GD12525. (529 aa)
	DsimGD13487	GD13487. (192 aa)
	DsimGD13607	GD13607. (612 aa)
	Cdc37	Cdc37. (389 aa)
	DsimGD12467	GD12467. (325 aa)
	DsimGD14666	GD14666. (332 aa)
	DsimGD14225	GD14225. (340 aa)
	DsimGD14703	GD14703. (398 aa)
	Hsp83	Heat shock protein 83. (717 aa)
	DsimGD12837	GD12837. (555 aa)
	DsimGD12787	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (585 aa)
	DsimGD13273	GD13273. (1328 aa)
	DsimGD12751	GD12751. (1097 aa)
	Rpd3	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (521 aa)
	DsimGD13896	GD13896. (2022 aa)
	DsimGD14871	GD14871. (558 aa)
	DsimGD19365	GD19365. (741 aa)
	DsimGD19364	GD19364. (1624 aa)
	spas	Spastin; ATP-dependent microtubule severing protein. Stimulates microtubule minus-end depolymerization and poleward microtubule flux in the mitotic spindle. Regulates microtubule stability in the neuromuscular junction synapse. Involved in lipid metabolism by regulating the size and distribution of lipid droplets. Involved in axon regeneration by regulating microtubule severing. Belongs to the AAA ATPase family. Spastin subfamily. (758 aa)
	DsimGD16633	GD16633. (295 aa)
	Dl	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (823 aa)
	DsimGD18792	GD18792; Belongs to the protein kinase superfamily. (421 aa)
	DsimGD21113	GD21113. (465 aa)
	pros	Prospero. (623 aa)
	DsimGD18245	GD18245. (596 aa)
	DsimGD19218	GD19218. (610 aa)
	DsimGD21196	GD21196. (538 aa)
	DsimGD20218	GD20218. (640 aa)
	DsimGD18691	GD18691. (698 aa)
	DsimGD20732	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (499 aa)
	DsimGD20735	GD20735. (682 aa)
	HLHmdelta	E(Spl) region transcript mdelta. (173 aa)
	HLHm3	HLHm3. (224 aa)
	DsimGD19788	GD19788. (370 aa)
	DsimGD19615	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (438 aa)
	DsimGD19794	GD19794. (182 aa)
	DsimGD19805	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (156 aa)
	DsimGD19806	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (479 aa)
	KATNA1-2	Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. (668 aa)
	DsimGD20313	GD20313. (911 aa)
	Ama	Amalgam. (333 aa)
	DsimGD19515	GD19515. (374 aa)
	DsimGD19499	GD19499. (233 aa)
	DsimGD20405	GD20405. (1320 aa)
	DsimGD20936	GD20936; Belongs to the small GTPase superfamily. SAR1 family. (193 aa)
	DsimGD19971	GD19971. (1814 aa)
	DsimGD19972	GD19972. (270 aa)
	DsimGD19996	GD19996. (205 aa)
	DsimGD20006	GD20006. (510 aa)
	DsimGD18402	GD18402. (581 aa)
	DsimGD18390	GD18390. (355 aa)
	pnt	Pnt. (354 aa)
	DsimGD21513	GD21513. (911 aa)
	DsimGD16829	GD16829. (994 aa)
	DsimGD24393	GD24393. (950 aa)
	plexA	PlexA. (900 aa)
	DsimGD17844	GD17844. (295 aa)
	DsimGD17039	GD17039. (1079 aa)
	DsimGD17040	GD17040. (150 aa)
	DsimGD16362	GD16362. (3196 aa)
	N	Notch. (811 aa)
	DsimGD16640	GD16640. (549 aa)
	DsimGD15903	GD15903. (515 aa)
	DsimGD16316	GD16316. (2741 aa)
	DsimGD15629	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (969 aa)
	DsimGD16494	GD16494. (1262 aa)
	sc	Scute. (334 aa)
	DsimGD16504	GD16504. (466 aa)
	DsimGD17439	GD17439. (88 aa)
	DsimGD15564	GD15564. (572 aa)
	DsimGD15563	GD15563. (326 aa)
	l(1)sc	Lethal of scute. (257 aa)
	HLHm7	Enhancer of split complex m7 protein. (186 aa)
	HLHmbeta	Enhancer of split mbeta protein. (195 aa)
	E(spl)	Basic helix-loop-helix transcription factor. (179 aa)
	HLHmgamma	Enhancer of split complex mgamma protein. (205 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ama	DsimGD19364	B4QYX4	B4QS07	Amalgam.	GD19364.	0.514
Ama	DsimGD19365	B4QYX4	B4QS06	Amalgam.	GD19365.	0.514
Cdc37	DsimGD19364	B4QML0	B4QS07	Cdc37.	GD19364.	0.718
Cdc37	DsimGD19365	B4QML0	B4QS06	Cdc37.	GD19365.	0.718
Cdc37	Hsp83	B4QML0	B4QP43	Cdc37.	Heat shock protein 83.	0.982
Dl	DsimGD19364	B4QTE8	B4QS07	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GD19364.	0.647
Dl	DsimGD19365	B4QTE8	B4QS06	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	GD19365.	0.647
Dl	N	B4QTE8	B4R3W6	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch.	0.999
DsimGD10199	N	B4QF86	B4R3W6	GD10199.	Notch.	0.705
DsimGD10200	N	B4QF85	B4R3W6	GD10200.	Notch.	0.705
DsimGD10311	DsimGD23492	B4QDB6	B4Q5U3	GD10311.	Serine/threonine-protein phosphatase.	0.852
DsimGD10311	DsimGD23499	B4QDB6	B4Q689	GD10311.	GD23499.	0.916
DsimGD10466	DsimGD10750	B4QE77	B4QAL9	GD10466.	GD10750; Belongs to the G-protein coupled receptor 2 family.	0.761
DsimGD10466	DsimGD14489	B4QE77	B4QJZ3	GD10466.	GD14489; Belongs to the G-protein coupled receptor Fz/Smo family.	0.927
DsimGD10466	DsimGD19364	B4QE77	B4QS07	GD10466.	GD19364.	0.501
DsimGD10466	DsimGD19365	B4QE77	B4QS06	GD10466.	GD19365.	0.501
DsimGD10466	DsimGD25642	B4QE77	B4QGC4	GD10466.	Protein kinase C.	0.566
DsimGD10467	DsimGD10750	B4QE78	B4QAL9	GD10467.	GD10750; Belongs to the G-protein coupled receptor 2 family.	0.761
DsimGD10467	DsimGD14489	B4QE78	B4QJZ3	GD10467.	GD14489; Belongs to the G-protein coupled receptor Fz/Smo family.	0.927
DsimGD10467	DsimGD19364	B4QE78	B4QS07	GD10467.	GD19364.	0.501