(25 nodes) Positive regulation of ERK1 and ERK2 cascade network (Drosophila simulans)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	phl	Phl. (739 aa)
	DsimGD17440	GD17440. (523 aa)
	Ras85D	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis. (189 aa)
	DsimGD17441	GD17441. (104 aa)
	DsimGD15319	GD15319. (334 aa)
	DsimGD15318	GD15318. (102 aa)
	DsimGD18487	GD18487. (85 aa)
	DsimGD21629	GD21629. (594 aa)
	R	Roughened. (184 aa)
	DsimGD22428	Receptor protein-tyrosine kinase. (1215 aa)
	DsimGD22427	GD22427. (196 aa)
	DsimGD24240	GD24240. (280 aa)
	DsimGD11781	GD11781; Belongs to the cyclic nucleotide phosphodiesterase family. (840 aa)
	DsimGD10390	Tyrosine-protein kinase. (517 aa)
	drk	Drk. (182 aa)
	DsimGD11074	GD11074. (106 aa)
	DsimGD11601	GD11601. (705 aa)
	DsimGD25528	GD25528. (1326 aa)
	DsimGD13897	GD13897; Belongs to the peptidase C19 family. (1557 aa)
	DsimGD13173	GD13173. (422 aa)
	Cdc37	Cdc37. (389 aa)
	DsimGD12228	GD12228; Belongs to the G-protein coupled receptor 1 family. (600 aa)
	DsimGD21241	GD21241. (723 aa)
	ksr	Ksr. (967 aa)
	DsimGD21384	GD21384; Belongs to the DOCK family. (2149 aa)

Your Current Organism:

Drosophila simulans

NCBI taxonomy Id: 7240
Other names: D. simulans

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Cdc37	DsimGD11601	B4QML0	B4QG50	Cdc37.	GD11601.	0.688
Cdc37	ksr	B4QML0	B4QWW4	Cdc37.	Ksr.	0.845
Cdc37	phl	B4QML0	B4R3I0	Cdc37.	Phl.	0.865
DsimGD10390	DsimGD11074	B4QCQ4	B4QFY1	Tyrosine-protein kinase.	GD11074.	0.902
DsimGD10390	DsimGD11601	B4QCQ4	B4QG50	Tyrosine-protein kinase.	GD11601.	0.946
DsimGD10390	DsimGD13173	B4QCQ4	B4QIT1	Tyrosine-protein kinase.	GD13173.	0.548
DsimGD10390	DsimGD15318	B4QCQ4	B4NS16	Tyrosine-protein kinase.	GD15318.	0.685
DsimGD10390	DsimGD15319	B4QCQ4	B4NS15	Tyrosine-protein kinase.	GD15319.	0.685
DsimGD10390	DsimGD17440	B4QCQ4	B4R7P5	Tyrosine-protein kinase.	GD17440.	0.495
DsimGD10390	DsimGD17441	B4QCQ4	B4R7P6	Tyrosine-protein kinase.	GD17441.	0.495
DsimGD10390	DsimGD18487	B4QCQ4	B4NVM4	Tyrosine-protein kinase.	GD18487.	0.495
DsimGD10390	DsimGD21241	B4QCQ4	B4QVG0	Tyrosine-protein kinase.	GD21241.	0.475
DsimGD10390	DsimGD22427	B4QCQ4	B4Q6C4	Tyrosine-protein kinase.	GD22427.	0.422
DsimGD10390	DsimGD22428	B4QCQ4	B4Q6C3	Tyrosine-protein kinase.	Receptor protein-tyrosine kinase.	0.422
DsimGD10390	DsimGD25528	B4QCQ4	B4QI13	Tyrosine-protein kinase.	GD25528.	0.558
DsimGD10390	R	B4QCQ4	Q71TY0	Tyrosine-protein kinase.	Roughened.	0.526
DsimGD10390	Ras85D	B4QCQ4	P83831	Tyrosine-protein kinase.	Ras-like protein 1; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in eye development by regulating cell growth, survival of postmitotic ommatidial cells and differentiation of photoreceptor cells. During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis.	0.963
DsimGD10390	drk	B4QCQ4	B4QEE6	Tyrosine-protein kinase.	Drk.	0.702
DsimGD10390	ksr	B4QCQ4	B4QWW4	Tyrosine-protein kinase.	Ksr.	0.914
DsimGD10390	phl	B4QCQ4	B4R3I0	Tyrosine-protein kinase.	Phl.	0.987